RESUMO
Results of treatment of gastric cancer with using preoperative superselective intraarterial polychemotherapy are described. The method was used in 57 patients with gastric cancer of the III-IV degrees and was followed by radical surgical treatment. The use of chemotherapy and operation resulted in complete destruction of the tumor in 63.8% of cases, partial regression in 19.2%. An inconsiderable effect was obtained in 17.0%. One-year survival was noted in 100% of the patients.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Cuidados Pré-Operatórios/métodos , Neoplasias Gástricas/tratamento farmacológico , Neoplasias Gástricas/cirurgia , Adulto , Terapia Combinada , Gastrectomia , Humanos , Infusões Intra-Arteriais , Pessoa de Meia-Idade , Síndromes Pós-Gastrectomia/epidemiologia , Indução de Remissão , Neoplasias Gástricas/mortalidadeAssuntos
Hiperglicemia/metabolismo , Neoplasias Experimentais/tratamento farmacológico , Animais , Antineoplásicos/uso terapêutico , Carcinoma/tratamento farmacológico , Carcinoma/fisiopatologia , Hiperglicemia/complicações , Neoplasias Experimentais/complicações , Neoplasias Experimentais/metabolismo , Ratos , Ratos EndogâmicosRESUMO
Using pH glass microelectrodes with maximum diameters of 100-200 micron (sensitivity 55-60 mV/pH unit at 37 degrees C; drift 0,001-0,002 pH unit/hr) pH has been measured in transplanted tumors (Guerin carcinoma, Pliss lymphosarcoma, Krocker sarcoma) and in muscle under artificial hyperglycaemia. We showed the ability of inorganic phosphate to amplify the process of acidification of the tumor tissue under these conditions. Using inorganic phosphate it was possible to reach pH values of 4,6-5,0 in different experimental tumors.
