Immunistochemical Analysis of the Expression of TGFß, Galectin-1, Vimentin, and Thrombospondin in Gastric Cancer Associated with Systemic Undifferentiated Connective Tissue Dysplasia.

We performed immunohistochemical analysis of the expression of TGFß, galectin-1, vimentin, and thrombospondin in the mucosa in gastric cancer of diffuse and intestinal type associated with systemic undifferentiated connective tissue dysplasia. In diffuse gastric cancer, both with and without association with connective tissue dysplasia, a higher level of expression of TGFß, galectin-1, vimentin, and thrombospondin in the tumor was detected in comparison with the perifocal and tumor zones in intestinal gastric cancer, which may reflect the pathogenetic peculiarities of the two histotypes of gastric cancer. Intestinal type of gastric cancer associated with connective tissue dysplasia is characterized by a high level of expression of galectin-1 and vimentin in the perifocal zone and TGFß in the tumor zone. The pattern of expression of the studied markers can reflect both the pathogenetic peculiarities of the two histotypes of gastric cancer and peculiar expression of some growth factors, cytoskeleton proteins, and matrix-cell proteins associated with undifferentiated connective tissue dysplasia which may contribute to epithelial-mesenchymal transition.

[Epidemiology of ischemic heart disease and characteristics of atherosclerosis in male residents in Yakutsk]. / Epidemiologiia ishemicheskoi bolezni serdtsa i osobennosti ateroskleroza u muzhchin Yakutska.

AIM: To study trends in prevalence, risk factors (RF) and mortality of ischemic heart disease (IHD), contribution of RF to risk of death due to IHD and other cardiovascular diseases (CVD) among male population of Yakutsk; to determine characteristics of atherosclerosis among native male population and migrants. MATERIAL AND METHODS: A clinicopathological epidemiological trial covered male population of Yakutsk. It was performed by standard techniques within the scope of the cooperative program. RESULTS: The analysis of the trends for the last 10 years demonstrates a marked rise in the incidence rates of arterial hypertension (AH), overweight and hypercholesterolemia. CVD mortality reached 38.4% of overall mortality. Such factors as AH, smoking, IHD, ischemic ECG changes and overweight contribute much to the integral risk of CVD death. A comparative morphometric analysis of atherosclerosis development in 1965-1968 and 1985-1988 showed accelerated development of atherosclerosis both among native population and migrants in 1985-1988. There are population differences in development of atherosclerosis in males from native population and migrants. The effects of trace elements on formation of atherosclerosis components in the Far North were evaluated. CONCLUSION: Present-day epidemiological situation in relation to IHD and other CVD necessitates further monitoring of the situation, activation of primary and secondary IHD prevention among population of the Far North.

[Contemporary immuno-allergic aspects in the course of chronic gastric erosion]. / Sovremennye immunoallergicheskie aspekty techeniia khronicheskikh érozii zheludka.

Among significant factors in pathogenesis of chronic gastric erosions (CGE), the infectious-allergic factor is essential. At the height of CGE recurrence there were high titers of specific IgE antibodies to infectious, home, food and plant allergens associated with high levels of serum immunoglobulins A and G. Persistence in remission of high and moderate titers of specific IgE indicated chronicity of the disease and expected recurrence.