[Repair processes in human cultured cells upon exposure to nickel salts and their modification]. / Reparativnye protsessy v kul'tiviruemykh kletkakh cheloveka pri vozdeistvii soli nikelia i ikh modifikatsiia.

The genetic activity of nickel sulfate was estimated from the viability, decreased DNA replication, and increased DNA repair synthesis in cultured human fibroblasts and peripheral blood lymphocytes. All but the viability tests showed the mutagenic effect of nickel sulfate. Pretreatment with ascorbic acid modified DNA repair synthesis and increased the viability of lymphocytes treated with nickel sulfate.

[Formation of sister chromatid exchanges and reparative DNA synthesis in workers exposed to nickel compounds]. / Formirovanie sestrinskikh khromatidnykh obmenov i reparativnyi sintez DNK u rabochikh, kontaktiruiushchikh s soedineniiami nikelia.

In workers from a nickel processing plant, residents of the surrounding industrial zone, and a control group, levels of sister chromatid exchanges (SCE, 33 individuals) and DNA repair synthesis (DRS, 79 individuals) were estimated. Individual variations in SCE level did not correlate to the duration of exposure to nickel compounds or the level of pollution. A statistically significant increase of SCE level among smokers compared to nonsmokers was revealed. Workers exposed to nickel compounds were demonstrated to have a statistically significant increase in the inhibition of DNA repair synthesis.