[Continuous long-term treatment with diuretics of hypertension and the status of the renin-angiotensin-aldosterone system]. / O dlitel'nom nepreryvnom lechenii diuretikami bol'nykh gipertonicheskoi bolezn'iu i sostoianie renin-angiotenzin-al'dosteronovoi sistemy.

One hundred fifty eight patients with essential hypertension (both in- and out-patients) at stages IIA and IIB were treated with diuretics: furosemide (120 mg/day) during three days followed by hydrochlorothiazide in the doses that allow maintaining the renal sodium and water transport of the changed level. Criteria developed for prognosis of the efficiency of diuretic therapy according to the degree of reduction of the mean BP and plasma renin activity after 3-day furosemide intake; indications were worked out for a simultaneous prescription of the potassium-sparing drug amiloride. A good hypotensive effect was noted (reduction of the mean BP by 10 mm Hg) during the first month of treatment in 60 and 70% of in-patients, and in 22 and 40% out-patients with IIB and IIA stages of the disease, respectively. During 6 months of prolonged treatment with diuretics (1-2 years) the sensitivity of the patients to the therapy was increased that permitted the dose of hydrochlorothiazide to be reduced to 25 mg a day or every other day. Patients with good hypotensive effect of therapy were noted to have less pronounced degree of activation of the renin-angiotensin-aldosterone system, than that in patients with ineffective treatment.

[Detection and prophylactic treatment of arterial hypertension at an industrial enterprise]. / Vyiavlenie i profilakticheskoe lechenie arterial'noi gipertenzii na promyshlennom predpriiatii.

Examination was conducted of 390 men (84.2%) aged from 20 to 38 and of 1116 men of 40 to 54 years of age. Arterial hypertension was found in 39% of the examined. One year later the incidence of arterial hypertension in the older age group decreased to 25.4%. Repeated examination revealed increased arterial pressure in 66.7% of persons of the 40- to 54-year-old group. Regular treatment of arterial hypertension conducted a the medical center of the enterprise for 1 year raised the effectiveness of treatment form 2.7 to 62.2%.