RESUMO
The paper presents the results of investigating an association between the frequency of chromosome aberrations and the CYP1A1, CYP1A2*1F GSTM1, and GSTT1 genes involved in xenobiotic biotransformation in workers engaged in heat and power engineering. The group of workers is shown to have a significantly higher rate of metaphases with aberrations (4.03 +/- 0.17%; n = 231) than the control group (2.06 +/- 0.17%; n = 141). Cytogenetic disorders are not found to depend on gender, age, and length of service. The study indicated that the level of chromosome aberrations was significantly higher in carriers of the CTP1A1 C/C, GSTM1 0/0 and GSTT1 0/0 genotypes. In individuals with a combination of the GSTM1 0/0 and GSTT1 0/0 genotypes, the level of chromosome aberrations was ascertained to be significantly higher than that in those with the protective form of these genes.
Assuntos
Aberrações Cromossômicas , Genoma Humano , Polimorfismo Genético , Centrais Elétricas , Local de Trabalho/normas , Adulto , Biotransformação/genética , Estudos de Casos e Controles , Aberrações Cromossômicas/induzido quimicamente , Aberrações Cromossômicas/estatística & dados numéricos , Interpretação Estatística de Dados , Genótipo , Humanos , Mutagênicos/farmacocinética , Mutagênicos/toxicidade , Exposição Ocupacional/efeitos adversos , Xenobióticos/farmacocinética , Xenobióticos/toxicidadeRESUMO
Chromosomal aberration rate has been estimated in peripheral blood lymphocytes of subjects occupationally exposed to a set of hazardous factors (employees of the Kemerovo Heat Power Plant). The frequency of metaphases with aberrations in the workers (3.23 +/- 0.26%, N = 104) is significantly higher than in control subjects (2.11 +/- 0.28%, N = 70). The cytogenetic aberrations did not depend on the sex, age, duration of employment, or smoking.
Assuntos
Aberrações Cromossômicas , Dano ao DNA , Exposição Ocupacional/efeitos adversos , Centrais Elétricas , Adulto , Feminino , Humanos , Linfócitos , Masculino , Pessoa de Meia-Idade , SibériaRESUMO
GSTM1 and GSTT1 gene polymorphisms were studied in Shorians, Teleuts, and Caucasians of the Kemerovo region. It has been shown that distribution of homozygous deletions in the examined groups is significantly heterogeneous. The frequency of deletion genotypes and combinations of deletion in these genes was lower in Shorians and, Teleuts than in Caucasians.
