1.
Antibiot Med Biotekhnol
; 30(3): 201-4, 1985 Mar.
Artigo
em Russo
| MEDLINE
| ID: mdl-4015062
RESUMO
A method of quantitative determination of 3-phenyl-5-methyl-isoxazole-4-carbonyl chloride useful for its qualitative estimation at all stages of oxacillin industrial synthesis was developed. The methods is based on transformation of this semi-product into isopropyl ester followed by high efficiency liquid chromatography with the use of the "Milikhrom" chromatograph mad in the USSR. A variant of the typical method for determination of 3-phenyl-5-methyl-isoxazole-4-carbonyl chloride concentration in solution is described.