[Morphological features of fibro-cavernous pulmonary tuberculosis according to the surgical material]. / Morfologicheskie osobennosti fibrozno-kavernoznogo tuberkuleza legkikh na operatsionnom materiale.

The lungs and bronchopulmonary lymph nodes were studied in 203 patients aged 20-60 years operated for fibrocavernous tuberculosis. Histological, immunohistochemical and histoenzymological tests demonstrated that clinically diagnosed fibrocavernous tuberculosis comprises a heterogenous group. Specific alterations in the lymph nodes indicate progression of primary tuberculosis while the absence of such alterations is the sign of real fibro-cavernous tuberculosis.

[Molecular genetic characteristics of Mycobacterium tuberculosis isolated from patients operated on for pulmonary tuberculosis]. / Molekuliarno-geneticheskaia kharakteristika shtammov Mycobacterium tuberculosis, vydelennykh ot bol'nykh, operirovannykh po povodu tuberkuleza legkikh.

The RFLP-IS6110 assay was used to genotype 67 Mycobacterium tuberculosis isolated from different specimens (including intraoperative ones) of 24 patients operated on for chronic progressive pulmonary tuberculosis who lived in north-western Russia. More than half (53%) of 17 types of RFLP profiles of isolates are identical and typical of M. tuberculosis of the Beijing family. Comparing the results of isolate genotyping with clinical, microbiological, and pathomorphological findings allows cases of endogenous reactivation to be differentiated from exogenous (nosocomial, in particular) reinfection in recurrence. Beijing genotype strains are shown to cause more severe unarrested course of drug-resistant fibrocavernous tuberculosis. At the same time such strains are more frequently detected in relatively young persons with a shorter duration of the disease, which reflects current clonal Beijing genotype dissemination that present a severe epidemiological hazard.

[Tuberculosis statistics by sectional data]. / Statistika tuberkulëza po sektsionnym dannym.

Analysis of sectional schedules and autopsy protocols for 1,061 persons who died of tuberculosis in Saint Petersburg in 1984-1991 has provided data on the age and sex distribution of the victims, the distribution of various types of tuberculosis as the underlying or concomitant disease, on the incidence and pattern of its complications, concurrent and competitive abnormalities and the causes of death. Comparison of previous results of the previous studies made regularly since 1981 has revealed stable and labile statistical parameters that characterize the evolution of tuberculosis as a disease, its pathomorphism in Saint Petersburg over the past century.