RESUMO
The experiments on dietary intoxication of rats by HgI2 or Hg(NO3)2 show that the activities of lysosomal proteinase cathepsin B and cytosolic Ca(2+)-activated proteinases (calpains I and II) in the liver and kidney depend on the mercury salt solubility and the exposure duration. Mercury iodide and nitrate contribute more to inhibiting cathepsin B and calpains activities in the above tissues, respectively.
Assuntos
Cisteína Endopeptidases/efeitos dos fármacos , Cisteína Endopeptidases/metabolismo , Rim/enzimologia , Fígado/enzimologia , Compostos de Mercúrio/toxicidade , Administração Oral , Animais , Calpaína/efeitos dos fármacos , Calpaína/metabolismo , Catepsina B/efeitos dos fármacos , Catepsina B/metabolismo , Citosol/efeitos dos fármacos , Citosol/metabolismo , Dieta , Inibidores Enzimáticos/química , Inibidores Enzimáticos/toxicidade , Feminino , Iodetos/química , Iodetos/toxicidade , Rim/efeitos dos fármacos , Fígado/efeitos dos fármacos , Lisossomos/efeitos dos fármacos , Lisossomos/metabolismo , Compostos de Mercúrio/química , Nitratos/química , Nitratos/toxicidade , Proteínas/efeitos dos fármacos , Proteínas/metabolismo , Ratos , Sais/toxicidade , SolubilidadeRESUMO
The effect of host infection doze (10, 100, 1000 eggs) and developmental stages of helminths (larvae, adult nematodes) on the relationships in the system "Toxascaris leonina-Alopex lagopus" was studied experimentally. It has been established that 100 eggs are the threshold dose for helminths and 1000 eggs for the host. More distinct changes in the indices are characteristic of the parasite. Dynamics of host-parasite relationships in the development of the parasitic process correspond to helminth developmental stage. Larvae of T. leonina are most pathogenic for the host.
