[Malignant atrophic papulosis]. / Maligne atrophische Papulose.

A 53-year-old woman had noticed numerous papules on her trunk and proximal parts of the limbs. They had healed with a central scar surrounded by a reddish wall. Four months later she had to undergo laparotomy for ileus, resulting from a perforation in the region of the middle jejunum: it was excised and sutured over. At laparotomy white plaque-like lesions were noted on the serosa of both small and large intestine. Histological examination of the jejunal exudate and of a skin biopsy both demonstrated malignant atrophic papulosis (Köhlmeier-Dégos' disease). Treatment with ticlopidine, a platelet-aggregation inhibitor (250 mg twice daily), was initiated and she has now been free of extracutaneous symptoms for 6 years.

[Acute alveolitis in ulcerative colitis: extra-intestinal organ complication or drug side effect]. / Akute Alveolitis bei Colitis ulcerosa: Extraintestinale Organkomplikation oder Medikamentennebenwirkung.

The histories of three possible cases of 5-ASA-induced toxic interstitial lung disease are presented. In addition diagnostical methods and procedures for the differential-diagnosis are discussed and as diagnostical program for the identification of remedy-induced toxic lung-damages is explained.