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1.
Gan To Kagaku Ryoho ; 45(2): 282-284, 2018 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-29483421

RESUMO

BACKGROUND: Body temperatures in elderly patients undergoing a pancreaticoduodenectomy(PD)for treatment of pancreatic cancer have not been fully evaluated. We aimed to compare body temperature during a PD between elderly(75 years old)and non-elderly patients. METHODS: This retrospective study included patients who underwent PD between April 2012 and April 2014 at the Kanasgawa Cancer Center. Patients were categorized into 2 groups: elderly patients(≥75 years of age: group A)and non-elderly patients(<75 years of age: group B). Body temperatures were compared between the groups. RESULTS: We evaluated 58 patients-14 were classified into group A, and 44 into group B. Preoperative clinicopathological outcomes demonstrated no significant differences between patients. A comparison of body temperatures between the groups showed 36.3°C(before surgery)/36.1°C(at 1 hr)/36.3°C(at 2 hr)/36.7°C(at 3 hr)/36.8°C(at 4 hr)/37.1°C(at 5 hr)/37.4°C(at 6 hr)in group A compared to 36.2°C(before surgery)/36.2°C(at 1 hr)/36.4°C(at 2 hr)/36.6°C(at 3 hr)/ 36.9°C(at 4 hr)/37.0°C(at 5 hr)/37.3°C(at 6 hr)in group B. Results did not significantly differ between the groups. CONCLUSIONS: Our study suggests that body temperature is not affected by a patient's age.


Assuntos
Temperatura Corporal , Neoplasias Pancreáticas/fisiopatologia , Pancreaticoduodenectomia , Idoso , Feminino , Humanos , Masculino , Neoplasias Pancreáticas/cirurgia
2.
Nutrition ; 20(4): 358-63, 2004 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15043851

RESUMO

OBJECTIVE: We investigated the effects of vitamin E supplementation on the fatty acid composition of red blood cell membrane phospholipids and on the clinical observations in patients with hepatitis C virus. METHOD: Eight patients and control subjects were administered 500 mg/d of d-alpha-tocopherol for 12 wk. The alpha-tocopherol and fatty acid composition of phospholipids in red blood cells were analyzed before, at 4, 8, and 12 wk, and after 4 wk of washout of vitamin E administration. RESULTS: The alpha-tocopherol concentration in red blood cells increased 2.37-fold of the basal level during vitamin E supplementation. Serum alanine aminotransferase levels increased in five of eight patients with vitamin E supplementation. The arachidonic acid level, docosahexaenoic acid level, and ratio of polyunsaturated to saturated fatty acid in red blood cell membrane phospholipids, which were significantly lower in the patients than in the control subjects, were elevated at 8 and 12 wk after vitamin E supplementation. The improvement in fatty acid composition was observed particularly in the patients who responded to the vitamin E therapy. CONCLUSIONS: Vitamin E therapy for the prevention of disease progression in patients with hepatitis C virus may be effective.


Assuntos
Membrana Eritrocítica/química , Ácidos Graxos Insaturados/sangue , Hepatite C/sangue , alfa-Tocoferol/administração & dosagem , Alanina Transaminase/sangue , Ácido Araquidônico/sangue , Suplementos Nutricionais , Ácidos Docosa-Hexaenoicos/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fosfolipídeos/sangue
3.
Nutrition ; 19(9): 727-32, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12921881

RESUMO

OBJECTIVES: An abnormal fatty acid pattern in patients with advanced liver cirrhosis (LC) has been reported in plasma phospholipids and some other tissues. To elucidate the significance of arachidonic acid deficiency on the clinical pathophysiology of LC and hepatocellular carcinoma (HCC), we analyzed the fatty acid compositions of mononuclear cell phospholipids, plasma alpha-tocopherol, and thiobarbituric acid-reactive substances and serum tumor necrosis factor-alpha (TNF-alpha) in cirrhotic patients infected with the hepatitis C virus with and without HCC. METHODS: Twelve cirrhotic patients without HCC (LC patients) and 11 with HCC (HCC patients) were enrolled. Fatty acids were analyzed with gas chromatography. alpha-Tocopherol and TNF-alpha were analyzed by high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. Statistical analysis was performed by using the unpaired t test with Welch's correction and Spearman's rank-correlation analysis. RESULTS: Significantly low levels of linoleic, dihomo-gamma-linolenic, arachidonic, and eicosapentaenoic acids from mononuclear cell phospholipids were observed in LC and HCC patients compared with control subjects. Plasma alpha-tocopherol was lower and thiobarbituric acid-reactive substances were higher in HCC patients than in controls. Arachidonic acid molar percentage in mononuclear cell phospholipids correlated significantly with lymphocyte count (r = 0.460, P < 0.05) in the cirrhotic patients and with lymphocyte (r = 0.680, P < 0.01) and platelet (r = 0.763, P < 0.01) counts in all subjects. CONCLUSIONS: These results suggested that arachidonic acid in mononuclear cells may have an important role in the pathophysiology of hepatitis C virus associated with cirrhosis and that nutritional management preventing arachidonic acid deficiency may have some beneficial effects on the progression of LC.


Assuntos
Ácido Araquidônico/deficiência , Carcinoma Hepatocelular/sangue , Hepatite C/complicações , Leucócitos Mononucleares/química , Cirrose Hepática/sangue , Neoplasias Hepáticas/sangue , Idoso , Ácido Araquidônico/análise , Estudos de Casos e Controles , Cromatografia Gasosa , Cromatografia Líquida de Alta Pressão , Progressão da Doença , Ensaio de Imunoadsorção Enzimática , Ácidos Graxos/sangue , Feminino , Hepatite C/sangue , Humanos , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Fosfolipídeos/química , Contagem de Plaquetas , Substâncias Reativas com Ácido Tiobarbitúrico/análise , Fator de Necrose Tumoral alfa/análise , alfa-Tocoferol/análise , alfa-Tocoferol/sangue
4.
Nutrition ; 18(4): 304-8, 2002 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11934541

RESUMO

OBJECTIVE: We compared the habitual food intake and plasma fatty acid composition in cirrhotic patients living in two different regions in Japan, Okayama and Toyama, and evaluated the effects of dietary polyunsaturated fatty acid and alpha-tocopherol intake on serum alanine aminotransferase (ALT) activity. METHOD: A quantitative food-frequency questionnaire method was used. RESULTS: The significantly higher intake of fish in the patients living in Toyama resulted in higher plasma levels of docosahexaenoic acid and lower levels of arachidonic acid. Serum ALT activity correlated negatively with plasma arachidonic acid (r = -0.456, P < 0.05) and alpha-tocopherol (r = -0.505, P < 0.05) levels. Dietary intakes of vitamin E and polyunsaturated fatty acids (mg/g) correlated negatively with serum ALT (r = -0.377, P < 0.05). Dietary intake of linoleic acid and the ratio of polyunsaturated to saturated fatty acid in dietary fat correlated significantly with serum ALT (r = 0.604, P < 0.01, and r = 0.622, P < 0.01, respectively). The amount of vegetable intake correlated with intake of vitamin E and polyunsaturated fatty acid (r = 0.527, P < 0.02). CONCLUSIONS: These findings suggest that habitual food intake affects the plasma fatty acid profile and that elevated serum ALT may be related to arachidonic acid deficiency and vulnerability to lipid peroxidation in cirrhotic patients with hepatitis B and C viruses.


Assuntos
Ingestão de Alimentos/fisiologia , Ácidos Graxos Insaturados/deficiência , Comportamento Alimentar/fisiologia , Cirrose Hepática/complicações , Alanina Transaminase/sangue , Antioxidantes/análise , Ácidos Graxos Insaturados/sangue , Feminino , Humanos , Japão , Cirrose Hepática/sangue , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , alfa-Tocoferol/sangue
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