[Vegetovascular dysfunction as an integral parameter of high risk for cardiovascular diseases development in young subjects]. / Sindrom vegetososudistoi disfunktsii kak integral'nyi pokazatel' vysokogo riska razvitiia serdechno-sosudistykh zabolevanii u lits molodogo vozrasta s otiagoshchennoi nasledstvennost'iu.

AIM: To study manifestations of vegetative dystonia in children of probands from families with hereditary IHD load regarding the main risk factors. MATERIALS AND METHODS: 44 individuals aged 21 +/- 0.7 years were selected out of 111 children from 103 examined families the fathers of which had transmural or macrofocal myocardial infarction at the age under 50. 22 of 44 examinees had syndrome of vegetovascular dystonia (VVD). RESULTS: Children of probands with family history of cardiovascular disease and having VVD had levels of cholesterol, triglycerides and apoB higher, but HDLP cholesterol lower than those free of VVD. In daughters of the probands insulin and hydrocortisone levels were high whereas sons with VVD had only insulin levels higher. CONCLUSION: Children of probands of both sexes had high coefficients of hormonal and metabolic adaptation dependent on the severity of VVD syndrome.

[Ischemic heart disease and metabolic syndrome X (family study)]. / Ishemicheskaia bolezn' serdtsa i komponenty metabolicheskogo sindroma X.

AIM: To evaluate prevalence of metabolic syndrome "X" (MS) components in the families of probands and their wives regarding the presence of hyperinsulinemia and in probands' children of both sexes regarding their having vegetovascular dystonia. MATERIAL AND METHODS: 92 families were selected by the proband who survived acute myocardial infarction (MI) at the age under 50: 92 probands (mean age 47 +/- 1.1 years), 57 probands' wives (mean age 47 +/- 0.7 years), 20 sons (mean age 18.3 +/- 0.8 years), 24 daughters (mean age 19.1 +/- 1.0 years). Two groups were formed: group 1 of 48 probands and 25 wives (the presence of hyperinsulinemia in the proband); group 2 of 44 probands and 32 their wives (controls with normal insulin levels). Anthropometric, arterial pressure and lipid-hormonal measurements were made by standard techniques. Nutrition was studied by random reproduction of 24-h diet. RESULTS: More factors of risk to develop atherosclerosis and MS"X" components in probands and their wives were found in group 1. More frequent in the parents were the following MS components: hypoalphacholesterolemia, overweight, arterial hypertension, hyperapolipoprotein-B-emia. Vegetovascular asthenia in the probands' children predisposed to cardiovascular diseases is closely linked with the presence of hypoalphacholesterolemia, hypertriglyceridemia, overweight and arterial hypertension. CONCLUSION: MS "X" for probands and their wives is a "malignant" risk factor for cardiovascular diseases; in the presence of IHD in father, vegetovascular asthenia in children is a risk factor of cardiovascular disease.

[The characteristics of the blood lipid composition in northern Selkups and in the immigrant population of northern Siberia and the problems of miscegenation]. / Osobennosti lipidnogo sostava krovi severnykh sel'kupov, prishlogo naseleniia Severa Sibiri i problemy metisatsii.

Blood lipid composition was studied in 507 Selkups, native population of Tyumen Province (199 males and 308 females), 245 Slavs living in the north for more than 5 years (97 males and 148 females), 189 first generation métis born in mixed marriages (68 males and 121 females). Three age groups were analyzed: 10-19 (group 1), 20-39 (group 2), 40-59 (group 3). Male métis from groups 1, 2 and 3 had the highest levels of HDLP cholesterol, the lowest of apoB and atherogenic index. Group 2 métis were in the intermediate position between Slavs and Selkups by concentrations of total and LDLP cholesterol and triglycerides. Group 3 métis males had the lowest levels of triglycerides and intermediate levels of total and LDLP cholesterol. Group 1 and 2 métis females had the highest levels of LDLP, the lowest of apoB and low atherogenic index. In group 3, levels of total cholesterol, LDLP cholesterol, apoB and atherogenic index were as high as in non-aboriginal Slavonic population.

Relationships between left hemisphere predominance and disturbances of lipid metabolism in different ethnic groups.

The purpose of this study was to analyze the relationships between brain hemisphere predominance and disturbance of lipid metabolism in atherosclerosis in different ethnic groups. Three groups of subjects were examined: 52 healthy Selkups (the isolated ethnic population of the Far North), 50 healthy Russian men, living in Novosibirsk, and 78 Russian men, living in Novosibirsk, who had myocardial infarction before the age of 50. Blood cholesterol, low density lypoprotein (LDL) and high density lypoprotein (HDL) levels of the subjects with different brain functional asymmetry were compared. The lack of either hemisphere predominance is the most common among the Selkups. The population of Selkups as a whole showed low concentrations of cholesterol and LDL in comparison with both Russian groups. For all examined groups the pattern of lipid metabolism has been worsened for the subjects showing the left hemisphere predominance. The changes of lipid metabolism indices in subjects with the dominant left hemisphere is discussed.

[The characteristics of the lipid-hormonal interrelations in young men with a history of myocardial infarct (based on family registry data in Novosibirsk and Bishkek)]. / Osobennosti lipidno-gormonal'nykh vzaimosviazei u molodykh muzhchin, perenesshikh infarkt miokarda (po materialam semeinykh registrov v Novosibirske i Bishkeke).

Altogether 226 male probands who suffered large-focal or transmural myocardial infarction (MI) before reaching 50 years were examined in Novosibirsk and Bishkek in one stage according to the unified program. In Novosibirsk all the probands were Russians whereas in Bishkek 75 probands were Kirghizs and 71 were Russians. The probands were examined within a period of 1 to 3 years after MI. The lipid and lipoprotein plasma content was determined by standardized methods on a Tekhnikon AAP autoanalyzer. The content of thyroid hormones, insulin and cortisol was measured by means of RIA-kits and that of apolipoprotein B (ApoB) by radial immunodiffusion. It turned out that the patients from Novosibirsk demonstrated the highest content of cholesterol, low density lipoprotein cholesterol, the highest index of atherogenicity, the highest concentration of ApoB, and hyperinsulinemia. In the probands of both nationalities from Bishkek, the lipid spectrum did not differ substantially from the populational norm, the content of ApoB in the Russian probands was slightly lower than in those from Novosibirsk whereas in Kirghizs, the least content of thyroxin was recorded.

Prognosis of myocardial infarction and brain functional asymmetry.

Seventy-eight men (mean age, 47.0 +/- 1.1 years) who had suffered from myocardial infarction were examined. Blood cholesterol, lipoproteins, triglycerides, insulin and cortisol concentrations were compared in patients with left hemisphere or right hemisphere cerebral dominance. Patients with left hemisphere dominance had more serious disease and much higher levels of blood cholesterol and lipoproteins. Patients with right hemisphere dominance had the highest levels of blood cortisol and insulin. The brain's functional asymmetry may be one of the risk factors for coronary atherosclerosis in subjects under the age of 50 years.

[The characteristics of the blood serum lipid composition in northern Selkups]. / Osobennosti lipidnogo sostava syvorotki krovi u severnykh sel'kupov.

A representative sample of native Selkup population (161 males and 237 females) aged 20-69 from the Tyumen region of the Russian Federation was examined for blood lipids using standard techniques. Measurement of mean cholesterol in males and females showed it to be 181.2 +/- 9.4 mg/dl and 188.2 +/- 8.5 mg/dl, respectively, that of low-density lipoproteins, high-density lipoproteins made up 112.0 +/- 9.7 mg/dl and 50.3 +/- 3.9 mg/dl for males and 118.4 +/- 9.0 mg/dl, 51.7 +/- 3.4 mg/dl, for females, respectively. Mean triglycerides concentration amounted to 86.1 +/- 7.0 in males against 87.4 +/- 6.7 mg/dl in females. Overall atherogenic index averaged 2.9 +/- 0.3. The findings evidence that northern Selkups (both males and females) have much lower content of blood cholesterol and low-density lipoprotein cholesterol than control populations from Novosibirsk and Moscow.

[The prevalence of the main risk factors among probands who have had a myocardial infarct at a young age and among their relatives (based on family registry data in Bishkek and Novosibirsk)]. / Rasprostranennost' osnovnykh faktorov riska sredi probandov, perenesshikh infarkt miokarda v molodom vozraste, i ikh rodstvennikov (po materialam semeinykh registrov v Bishkeke i Novosibirske).

Macrofocal or transmural myocardial infarction at the age under 50 in probands served the criterion for selection of 136 families in Bishkek and Novosibirsk (66 Kirghiz and 70 Russian families, respectively). Main risk factors in probands and their families were determined according to WHO methodological recommendations. Essential hypertension was more prevalent in probands and their families in Bishkek, while hypercholesterolemia was more common in Novosibirsk families. Smoking was documented in Bishkek and Novosibirsk probands in equal proportions, though there were more smokers among probands' sons in Bishkek. Overweight occurred with equal frequency in probands' wives and daughters in both cities, but in probands and their sons in Novosibirsk this risk factor appeared more prevalent. Novosibirsk cases of reduced levels of high-density lipoproteins cholesterol and triiodothyronine, elevated concentrations of apolipoprotein B and immunoreactive insulin outnumbered those in Bishkek.

[Restriction fragment length polymorphism of the apolipoprotein A-I gene among inhabitants of Novosibirsk]. / Polimorfizm dlin restriktsionnykh fragmentov gena apolipoproteina A-I sredi zhitelei g. Novosibirska.

Restriction fragments' length polymorphism in the region of apolipoprotein A-I (apo A-I) gene was investigated in Novosibirsk (Siberia, USSR) population. Correlation between PstI apo A-I alleles (2,2 kb-P1; 3,3 kb-P2) and total cholesterol, triglycerides, high density polyproteins cholesterol, and apolipoprotein A-I level was analysed. A tendency to increase in cholesterol index of atherogenicity and to decrease in high density lipoproteins cholesterol as well as apolipoprotein A-I level was shown to occur for P1P2 genotype patients.

[Rare types of myocardial infarction in young patients]. / Redkie varianty infarkta miokarda u bol'nykh molodogo vozrasta.

The authors report 5 cases of myocardial infarction pathogenetically unrelated to coronary heart disease. All the patients were males under 40 with pathological conditions: Marfan's syndrome, malformation of coronary artery, erythremia, infectious endocarditis, mechanic chest trauma.

[Lipid composition of blood sera of elderly and long-lived healthy and sick individuals]. / Lipidnyi sostav syvorotki krovi u zdorovykh i bol'nykh starcheskogo vozrasta.

Serum cholesterol (SC), HDL SC and triglycerides were measured in 303 senile patients aged 75-89 and 77 long-livers aged over 90. The concentrations obtained were low in healthy long-livers compared to senile subjects. SC, triglycerides and atherogenic index reached the highest values in senile subjects and long-livers with coronary heart disease and abnormal cerebral circulation. Lower levels of HDL SC appeared in the same diseases in senile males and female long-livers against healthy subjects of the relevant age group.

[Strategy and organization of the primary prevention of ischemic heart disease at the Novosibirsk Science Center]. / Strategiia i organizatsiia pervichnoi profilaktiki ishemicheskoi bolezni serdtsa v novosibirskom nauchnom tsentre.

The authors present a program of a familial prophylactic medical examination that enables the strategy of the primary care of coronary heart disease (CHD) to be exercised in the families at greater risk for CHD. The system works within the framework of the public health bodies of the Novosibirsk Research Center where the district, shop, pediatric, obstetrical and gynecological services act integrally according to the uniform program. A profound specialized examination made it possible to reveal a group at greater risk for CHD in the families. The subsequent policy of the medical aid is based on the primary care and genetic monitoring of those families with a purpose of specific correction of the main risk factors.

[Characteristics of lipid-hormone relations in the families of probands with early development of myocardial infarction]. / Osobennosti lipidno-gormonal'nykh vzaimosviazei v sem'iakh probandov s rannim razvitiem infarkta miokarda.

163 subjects from families whose probands developed myocardial infarction under the age of 50 were examined for plasma levels of total cholesterol, HDLP cholesterol, triglycerides, T3, T4, immunoreactive insulin (IRI) and cortisol. Four family groups were selected: probands (58), wives (41), sons (33), daughters (31). Lipid composition was investigated by standard techniques on Technicon AAP, a hormonal spectrum--by RIA using Soviet kits. It was established that alpha-cholesterolemia in the families was a common finding. Probands and their families combine reduced plasma T3 levels with high incidence of atherogenic dyslipoproteinemia (ADLPE). Probands and their sons had hyperinsulinemia resultant in more frequent AFLPE while in probands' wives and daughters higher IRI levels brought about opposite results.

[Responsiveness of peripheral blood vessels to physiologically vasoactive agents in myocardial infarct]. / Reaktivnost' perifericheskikh sosudov po otnosheniiu k fiziologicheskimvazoaktivnym veshchestvam pri infarkte miokarda.

Changes in skin vascular responsiveness (VR) to six vasoactive agents were examined in 25 patients with myocardial infarction during its acute period. In small myocardial infarction, there was a synchronous increase in all VR types on days 1-7 followed by its normalization on day 14. VR synchronization was also observed in transmural myocardial infarction, yet increased VR to vasoconstrictive agents such as noradrenaline, adrenaline, and angiotensin II remained until the end of the fourth week without showing a tendency to normalization. Abnormal VR was seen in the most severe fatal cases. The synchronous and cyclic VR changes observed in myocardial infarction were absent in patients with unstable angina that did not result in myocardial infarction.

[The life style and indices of the blood lipid composition of elderly subjects]. / Obraz zhizni i pokazateli lipidnogo sostava krovi u liudei starcheskogo vozrasta.

A study was made of the content of total cholesterol (TCh), high-density lipoprotein cholesterol and triglycerides (TG) in 109 persons aged 75-89 years of both sexes depending on tobacco smoking (14 persons), prolonged alcohol abuse (15 persons), and on hypodynamia (30 persons). A positive correlation was obtained between the content of TCh in blood serum and hypodynamia, between the content of TG, alcohol abuse, tobacco smoking and hypodynamia. Meanwhile a negative correlation was established between the content of high density lipoprotein cholesterol and hypodynamia and tobacco smoking.

[Medico-social and clinico-biochemical aspects of longevity in Siberia]. / Uber medizinisch-soziale und klinisch-biochemische Aspekte der Langlebigkeit in Sibirien.

Over 90-year old inhabitants of districts of Novosibirsk were questioned in connection with sociological studies about their living habits. The authors consider the genetically determined system of monooxygenases for the elimination of foreign bodies (xenobiotics) to be important, but they are also involved in the synthesis of biologically active substances in the organism and thus by no means of minor importance to the phenomenon of longevity.