RESUMO
The function of microRNAs (miRNAs) in tumorigenesis has been extensively investigated. In the present study, the aim was to investigate the expression and role of miR204 in Bcell lymphoma. The present study demonstrated that miR204 is downregulated in Bcell lymphoma. Using in vitro studies, overexpression of miR204 was shown to inhibit growth in Daudi and Raji Bcell lymphoma cell lines. Furthermore, miR204 could bind the 3'untranslated region of signal transducer activator of transcription 5 (STAT5), a transcription factor that promotes Bcell lymphoma oncogenesis. Reintroduction of STAT5 reversed the antiproliferative roles of miR204, confirming the specific importance of STAT5 for miR204 action in cell proliferation. The present study suggests a novel mechanism for dysregulated miRNAs in the progression of Bcell lymphoma.