1.
Chemistry
; 28(27): e202200191, 2022 May 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35285989
RESUMO
We report herein a highly efficient palladium-catalyzed carbene insertion into strained Si-C bonds of benzosilacyclobutanes, which provides an efficient method to access α-chiral silanes. With a sterically hindered ligand, carbene insertion into the C(sp3 )-Si bond of benzosilacyclobutanes occurred in excellent site- and enantioselectivity, while C(sp2 )-Si bond insertion occurred selectively with less sterically hindered ligands. Reaction mechanism, in particular the roles of the chiral ligands in controlling the site-selectivity of the insertion reactions, are elucidated by using hybrid density functional theory.