[The principles of constructing a data bank applicable to the problem of physiological standards in space medicine]. / Printsipy postroeniia banka dannykh primenitel'no k probleme fiziologicheskoi normy v kosmicheskoi meditsine.

The norm is a more complex problem in physiology and in space medicine in particular. Definition of norm and health concepts is analyzed. Classification of functional states based on the adaptation and homeostasis concepts is proposed. Various approaches to determination of a norm are described. Three types of the norms which are of significance for space medicine, namely rest norm, reaction norm, adaptive norm are identified. The structure of data bank containing information on the standards is described. The central data bank structure is considered.

[Development of an integrated software program to analyze statistically the results of complex investigations in space biology and medicine]. / Razrabotka integrirovannogo paketa programmno-matematicheskikh sredstv statisticheskogo analiza rezultatov kompleksnykh issledovanii po kosmicheskoi biologii i meditsine.

A concept of implementing the problem-oriented statistical software based on an application of expert systems is presented. The shortcomings of existing statistical software for personal computers and trends of their improvements are analyzed. Recommendations on designing of statistical expert systems can be used by the statisticians, mathematicians, programmers and users not being professionals in these fields. Integrated statistical software will make it possible to perform additional retrospective analysis and to check up the large arrays of previously gained data and to obtain supplementary scientific information and to find new regularities in the previous experimental findings.

Amino acid sequence pattern in the regulatory peptides.

The essential properties of the primary structure of regulatory peptides, i.e. amino acid residues and their combinations, which are characteristic of the whole population of regulatory peptides, have been revealed using statistical methodology. These properties are as follows: increased content of certain residues (Gly, Pro, Phe, Arg, Tyr, Met and Trp) as well as an increased rate of occurrence of certain pairs of residue as compared with proteins, a random sequence of residues and "nonregulatory" peptides. By representing regulatory peptides as a sequence of hydrophobic (2 types) and hydrophilic (3 types) segments, the pattern for alternation of these segments in regulatory peptides has been determined. The segments were classified into 5 types according to the peculiarities of mutual localization of hydrophobic and hydrophilic residues within the primary structure of regulatory peptides. As compared with proteins, "nonregulatory" peptides and a random sequence of segments, regulatory peptides were characterized by an increased frequency of 4 particular pairs of segments among 12 theoretically possible pairs. These 4 pairs are fragments of the periodic segment sequence with periods of 4 segments. The revealed pattern indicates that there exists a general principle of the regulatory peptide primary structure organization and possibly a common type of the regulatory peptides flexible peptide chain folding at the ligand-receptor complex formation.