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3.
Eksp Klin Farmakol ; 59(3): 40-3, 1996.
Artigo em Russo | MEDLINE | ID: mdl-8974583

RESUMO

The influence of hypokinesia on phospholipid composition of the brain tissue was investigated. Hypokinesia was found to cause significant disorders in the phospholipid composition. Changes exhibit a phase character and are more pronounced on the 15-th and 30-th days of hypokinesia. The use of GABA and pyracetam promotes the processes aimed at normalization of the phospholipid metabolism in the brain tissue.


Assuntos
Encéfalo/efeitos dos fármacos , Hipocinesia/tratamento farmacológico , Fármacos Neuroprotetores/uso terapêutico , Fosfolipídeos/metabolismo , Piracetam/uso terapêutico , Ácido gama-Aminobutírico/uso terapêutico , Animais , Encéfalo/metabolismo , Química Encefálica/efeitos dos fármacos , Cromatografia em Camada Fina , Avaliação Pré-Clínica de Medicamentos , Hipocinesia/metabolismo , Masculino , Fosfolipídeos/análise , Ratos , Fatores de Tempo
4.
Biokhimiia ; 58(12): 1880-5, 1993 Dec.
Artigo em Russo | MEDLINE | ID: mdl-8292649

RESUMO

The effect of R-plasmid on the qualitative and quantitative compositions of phospholipids and their fatty acids in bacterial (S. derby) cells has been studied. It has been found that the lack of R-plasmid in bacterial cells leads to a sharp decrease in the phospholipid content, in the phosphatidylcholine content in particular, and causes an increase in the per cent content of lysophosphatidylcholines. The per cent content of saturated and nonsaturated fatty acids of phospholipids in plasmid-free cells does not change appreciably. In the plasmid-free strain of S. derby the intensity of lipid peroxidation is associated with a relatively high content of alpha-tocopherol.


Assuntos
Ácidos Graxos/fisiologia , Fosfolipídeos/fisiologia , Plasmídeos , Salmonella/genética , Membrana Celular/química , Ácidos Graxos/análise , Fosfolipídeos/análise , Salmonella/química
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