[Obesity - A Risk Factor for Psoriasis and COVID-19]. / Obesidad: factor de riesgo para psoriasis y COVID-19.

Obesity is a major health problem whose well-known association with psoriasis has been amply described. The importance of obesity as a risk factor for poor prognosis in the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has recently been demonstrated. This review examines a possible relationship between obesity, psoriasis, and COVID-19, analyzing the pathophysiological links and their practical implications. On the one hand, a higher body mass index increases the risk of psoriasis and is also a factor in metabolic syndrome, which is common in patients with psoriasis and has been implicated in reducing the effectiveness of psoriasis treatments. On the other hand, obesity is a risk factor for severe COVID-19 and mortality. Obesity also promotes a proinflammatory state in the lung, where it compromises respiratory mechanics.

Obesidad: factor de riesgo para psoriasis y COVID-19 / Obesity — A Risk Factor for Psoriasis and COVID-19

La obesidad es un importante problema sanitario y su asociación a la psoriasis es bien conocida y ha sido ampliamente descrita. Recientemente, su relevancia en relación con la COVID-19, enfermedad causada por el betacoronavirus SARS-CoV-2, se ha puesto de manifiesto al demostrarse que es un factor de mal pronóstico para estos pacientes. En este trabajo se analiza la relación que puede existir entre obesidad, psoriasis y COVID-19, analizando los nexos fisiopatológicos comunes entre estas entidades y las implicaciones prácticas de esta asociación. Por un lado, el aumento del índice de masa corporal aumenta el riesgo de padecer psoriasis y, además, la obesidad es un factor implicado tanto en el síndrome metabólico, que también está incrementado en pacientes con psoriasis, como en una menor eficacia de los tratamientos. Por otro lado, la obesidad es un factor de riesgo para gravedad de la COVID-19 y para su mortalidad. Además, a nivel pulmonar promueve un estado proinflamatorio y tiene un efecto mecánico desfavorable (AU)

Obesity is a major health problem whose well-known association with psoriasis has been amply described. The importance of obesity as a risk factor for poor prognosis in the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has recently been demonstrated. This review examines a possible relationship between obesity, psoriasis, and COVID-19, analyzing the pathophysiological links and their practical implications. On the one hand, a higher body mass index increases the risk of psoriasis and is also a factor in metabolic syndrome, which is common in patients with psoriasis and has been implicated in reducing the effectiveness of psoriasis treatments. On the other hand, obesity is a risk factor for severe COVID-19 and mortality. Obesity also promotes a proinflammatory state in the lung, where it compromises respiratory mechanics (AU)

Hemotórax como forma de debut de neoplasias pancreatobiliares: un reto diagnóstico / Haemothorax as an unusual presentation of pancreatobiliary neoplasms: a diagnostic challenge

El hemotórax es una entidad causada habitualmente por traumatismos. Sin embargo, puede aparecer en el contexto de otras etiologías como las neoplasias, las coagulopatías o las enfermedades autoinmunes. Mujer de 77 años que acudió al Servicio de Urgencias por tos y disnea. La radiografía de tórax mostró derrame pleural izquierdo. Se colocó un drenaje pleural obteniendo contenido hemático. Se realizó una TAC que descartó patología torácica, pero mostró una neoplasia pancreática. La pleuroscopia confirmó la existencia de carcinomatosis pleural. El estudio anatomopatológico de las biopsias pleurales junto con los hallazgos clínicorradiológicos fueron altamente sugestivos de la etiología maligna pancreática como etiología del hemotórax. La etiología del hemotórax no traumático supone en ocasiones un reto diagnóstico. En pacientes con hemotórax y sin antecedentes traumáticos debe descartarse la etiología neoplásica del mismo

Haemothorax is more often caused by trauma. However, non-traumatic haemothorax has been associated to other aetiologies such as neoplasms, coagulopathy or autoimmune diseases. A 77-year-old woman was admitted to Hospital because of cough and dyspnoea. Chest-X-ray showed left pleural effusion. A chest tube revealed the presence of an haemothorax. A CT-scan dismissed thoracic aetiology of haemothorax but showed a pancreatobiliary neoplasm. Pleuroscopy confirmed pleural carcinomatosis. The anatomopathological features of pleural biopsies altogether with clinical and radiological findings suggested pancreatobiliary malignancy as the aetiology of the haemothorax. The aetiology of non-traumatic haemothorax is sometimes a diagnostic challenge. In patients with non-traumatic haemothorax, neoplastic aetiology should be always dismissed

Obesidad: factor de riesgo para psoriasis y COVID-19 / Obesity - A Risk Factor for Psoriasis and COVID-19

La obesidad es un importante problema sanitario y su asociación a la psoriasis es bien conocida y ha sido ampliamente descrita. Recientemente, su relevancia en relación con la COVID-19, enfermedad causada por el betacoronavirus SARS-CoV-2, se ha puesto de manifiesto al demostrarse que es un factor de mal pronóstico para estos pacientes. En este trabajo se analiza la relación que puede existir entre obesidad, psoriasis y COVID-19, analizando los nexos fisiopatológicos comunes entre estas entidades y las implicaciones prácticas de esta asociación. Por un lado, el aumento del índice de masa corporal aumenta el riesgo de padecer psoriasis y, además la obesidad es un factor implicado tanto en el síndrome metabólico, que también está incrementado en pacientes con psoriasis, como en una menor eficacia de los tratamientos. Por otro lado, la obesidad es un factor de riesgo para gravedad de la COVID-19 y para su mortalidad. Además, a nivel pulmonar promueve un estado proinflamatorio y tiene un efecto mecánico desfavorable

Obesity is a major health problem whose well-known association with psoriasis has been amply described. The importance of obesity as a risk factor for poor prognosis in the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has recently been demonstrated. This review examines a possible relationship between obesity, psoriasis, and COVID-19, analyzing the pathophysiological links and their practical implications. On the one hand, a higher body mass index increases the risk of psoriasis and is also a factor in metabolic syndrome, which is common in patients with psoriasis and has been implicated in reducing the effectiveness of psoriasis treatments. On the other hand, obesity is a risk factor for severe COVID-19 and mortality. Obesity also promotes a proinflammatory state in the lung, where it compromises respiratory mechanics

Urticaria con infiltrado inflamatorio de predominio neutrofílico o urticaria neutrofílica. Estudio de sus características clínicas e histopatológicas y de su posible asociación con enfermedad reumatológica / Neutrophilic Urticaria or Urticaria With Predominantly Neutrophilic Inflammatory Infiltrate: Study of Its Clinical and Histopathologic Characteristics and Its Possible Association With Rheumatic Disease

Introducción: La urticaria neutrofílica (UN), descrita por Winkelmann en 1985, es una entidad que no está aún completamente definida y de una relevancia clínica desconocida. No obstante, ha sido considerada en la literatura reciente como marcador de enfermedad reumatológica. El objetivo principal de nuestro estudio es comparar la proporción de enfermedad reumatológica en urticarias con infiltrado predominantemente neutrofílico (UN) respecto a la encontrada en urticarias con infiltrado predominantemente no neutrofílico o convencionales. Material y métodos: De manera retrospectiva hemos revisado todas las urticarias biopsiadas en nuestro centro entre el 1 de enero de 1999 y el 28 de junio de 2009. Las hemos englobado en varios patrones morfológicos histopatológicos definidos. En los 84 pacientes incluidos hemos comparado las características clínicas e histológicas de las UN con las de las urticarias con infiltrados predominantemente no neutrofílicos o convencionales. Resultados: De nuestros 84 pacientes un 57,1% padecían UN. No hemos encontrado diferencias significativas en cuanto a la proporción de enfermedad reumatológica en las UN respecto a las convencionales. Sí hemos encontrado diferencias estadísticamente significativas respecto a la proporción de urticarias agudas con histopatología de UN en relación con aquellas con histopatología convencional, así como un mayor recuento de leucocitos en la UN. Conclusiones: En nuestra serie la proporción de UN encontradas (57,1%) es mayor que la descrita en la literatura, dato que puede deberse a nuestra tendencia a biopsiar lesiones recientes. Como conclusión de nuestro estudio cabe resaltar que la presencia de neutrófilos en las biopsias de urticaria es un hecho frecuente que no parece asociarse a otras comorbilidades (AU)

Introduction: Neutrophilic urticaria, described by Winkelmann in 1985, has yet to be completely defined and its clinical significance is poorly understood. Nevertheless, recent publications suggest that it could be a marker for rheumatic disease. The primary objective of this study was to compare the prevalence of rheumatic disease in 2 groups of patients with urticaria: those with conventional urticaria (non-neutrophilic inflammatory infiltrate) and those with neutrophilic urticaria. Material and methods: We retrospectively reviewed all biopsy samples taken from urticarial lesions in our hospital between January 1, 1999 and June 28, 2009. Urticaria was classified according to predefined morphologic and histopathologic patterns. We compared the clinical and histologic characteristics of neutrophilic urticaria with those of conventional urticarias in the 84 patients included. Results: Of the 84 patients, 57.1% had neutrophilic urticaria. We did not find significant differences between the percentages of patients with rheumatic disease between the neutrophilic and nonneutrophilic urticaria groups. In patients with acute urticaria, we found a significantly higher proportion of samples with histopathologic signs of neutrophilic urticaria as opposed to conventional histopathology. Patients with neutrophilic urticaria also had higher white blood cell counts. Conclusions: The percentage of samples with neutrophilic urticaria in this series (57.1%) is higher than the percentages reported in the literature, possibly because we tended to biopsy recent lesions. We highlight that the presence of neutrophils in the biopsies of urticaria is a common finding and does not appear to be associated with other diseases (AU)

[Neutrophilic urticaria or urticaria with predominantly neutrophilic inflammatory infiltrate: study of its clinical and histopathologic characteristics and its possible association with rheumatic disease]. / Urticaria con infiltrado inflamatorio de predominio neutrofílico o urticaria neutrofílica. Estudio de sus características clínicas e histopatológicas y de su posible asociación con enfermedad reumatológica.

INTRODUCTION: Neutrophilic urticaria, described by Winkelmann in 1985, has yet to be completely defined and its clinical significance is poorly understood. Nevertheless, recent publications suggest that it could be a marker for rheumatic disease. The primary objective of this study was to compare the prevalence of rheumatic disease in 2 groups of patients with urticaria: those with conventional urticaria (non-neutrophilic inflammatory infiltrate) and those with neutrophilic urticaria. MATERIAL AND METHODS: We retrospectively reviewed all biopsy samples taken from urticarial lesions in our hospital between January 1, 1999 and June 28, 2009. Urticaria was classified according to predefined morphologic and histopathologic patterns. We compared the clinical and histologic characteristics of neutrophilic urticaria with those of conventional urticarias in the 84 patients included. RESULTS: Of the 84 patients, 57.1% had neutrophilic urticaria. We did not find significant differences between the percentages of patients with rheumatic disease between the neutrophilic and nonneutrophilic urticaria groups. In patients with acute urticaria, we found a significantly higher proportion of samples with histopathologic signs of neutrophilic urticaria as opposed to conventional histopathology. Patients with neutrophilic urticaria also had higher white blood cell counts. CONCLUSIONS: The percentage of samples with neutrophilic urticaria in this series (57.1%) is higher than the percentages reported in the literature, possibly because we tended to biopsy recent lesions. We highlight that the presence of neutrophils in the biopsies of urticaria is a common finding and does not appear to be associated with other diseases.