[State-certified Health Professionals Supported by Telemedicine in the On-call Service of Community Doctors]. / Examinierte Gesundheitsfachkräfte mit telemedizinischer Unterstützung im kassenärztlichen Bereitschaftsdienst: Implementation und Validierung eines neuen Versorgungsmodells.

Background: Regional Associations of Statutory Health Insurance Physicians in Germany are obliged to provide around-the-clock non-emergency care. This includes out-of-hours care, weekends, and public holidays. Due to a growing shortage of specialised doctors in private practice - especially in more rural area - this well-established system might be about to collapse. A possible solution could lie in training medical personnel to work under telemedical supervision. Methods: The Association of Statutory Health Insurance Physicians of Lower Saxony, Klinikum Oldenburg AöR, and Johanniter-Unfall-Hilfe (JUH) Germany developed a pilot scheme in which specially-trained paramedics provided out-of-hours non-emergency medical services. Supervision was ensured by telemedical backup. Descriptive statistics were used to analyse the data. Results: The majority of cases occurred in urban areas in the afternoon or at night. Most problems could be resolved by providing patient counselling. The majority of patients presented with unspecific symptoms. Telemedical support by a medical doctor was only required in 2.1 % of cases. In Germany, treatment by paramedics is widely accepted. In 63.5 % of cases patients could remain in an ambulatory setting. Conclusions: Our study showed that non-emergency out-of-hours service can be competently delivered by paramedics under telemedical supervision. However, the expansion of high-speed wireless internet access is crucial for ensuring nationwide telemedical support. More research is needed to find out whether the described pilot scheme can be rolled out or even expanded in more rural areas of Germany.

Regular, in-situ, team-based training in trauma resuscitation with video debriefing enhances confidence and clinical efficiency.

BACKGROUND: To assess the clinical impact of a regular, multidisciplinary, video debriefed training intervention for trauma team members on real trauma resuscitations. In addition, attending personnel evaluated the training program via questionnaire. METHODS: The training intervention is a regular (monthly), video debriefed, team-based trauma simulation. Training takes place in the fully functional resuscitation bay (in-situ) of the Department of Traumatology at the Klinikum Oldenburg (Level 1, primary teaching hospital for the Carl von Ossietzky University Oldenburg) involving a complete trauma team. Laerdal® Resusci Anne® dummy serves as the patient simulator. A special feature is a structured video debriefing of each participating team to analyse team performance. Data before and after implementation of training was retrospectively analysed. RESULTS: We found a significant decrease in the time from arrival of the patient to computer tomography (CT, Spearman rank coefficient r = - 0.236, p = 0.001). Evaluation of the questionnaire by team members described a significant increase in self-confidence (p < 0.05). CONCLUSION: Monthly video assisted team based in situ training with video debriefing significantly reduces resuscitation time in the emergency bay.

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model.

The protein kinase C (PKC)-beta isoform has been implicated to play a pivotal role in the development of diabetic kidney disease. We tested this hypothesis by inducing diabetic nephropathy in PKC-beta-deficient (PKC-beta(-/-)) mice. We studied nondiabetic and streptozotocin-induced diabetic PKC-beta(-/-) mice compared with appropriate 129/SV wild-type mice. After 8 weeks of diabetes, the high-glucose-induced renal and glomerular hypertrophy, as well as the increased expression of extracellular matrix proteins such as collagen and fibronectin, was reduced in PKC-beta(-/-) mice. Furthermore, the high-glucose-induced expression of the profibrotic cytokine transforming growth factor (TGF)-beta1 and connective tissue growth factor were significantly diminished in the diabetic PKC-beta(-/-) mice compared with diabetic wild-type mice, suggesting a role of the PKC-beta isoform in the regulation of renal hypertrophy. Notably, increased urinary albumin-to-creatinine ratio persisted in the diabetic PKC-beta(-/-) mice. The loss of the basement membrane proteoglycan perlecan and the podocyte protein nephrin in the diabetic state was not prevented in the PKC-beta(-/-) mice as previously demonstrated in the nonalbuminuric diabetic PKC-alpha(-/-) mice. In summary, the differential effects of PKC-beta deficiency on diabetes-induced renal hypertrophy and albuminuria suggest that PKC-beta contributes to high-glucose-induced TGF-beta1 expression and renal fibrosis, whereas perlecan, as well as nephrin, expression and albuminuria is regulated by other signaling pathways.