[Annexin A2 expression in head and neck squamous cell carcinoma]. / Expresión de la anexina A2 en los carcinomas epidermoides de cabeza y cuello.

OBJECTIVE: Over-expression of annexin A2 (ANXA2) has been reported in various cancers. However, no data are available on the expression of this protein in head and neck squamous cell carcinomas (HNSCC). The objective of this preliminary study is to investigate the expression of ANXA2 in these carcinomas. MATERIAL AND METHOD: ANXA2 expression was analyzed by immunohistochemistry in paraffin-embedded sections from 9 patients with premalignant lesions and 21 patients with HNSCC. RESULTS: All dysplastic tissues showed significantly reduced ANXA2 expression compared to normal tissue. In contrast, ANXA2 expression was observed in all but one of the tumours studied. There was a significant correlation of lower ANXA2 expression with a poorer histological differentiation, larger tumours, and nodal metastases. CONCLUSIONS: Our data show for the first time that ANXA2 is expressed in head and neck squamous cell carcinomas and that its expression seems to be related with the degree of differentiation status of these tumours.

Expresión de la anexina A2 en los carcinomas epidermoides de cabeza y cuello / Annexin A2 expression in head and neck squamous cell carcinoma

Objetivo: La expresión de la anexina A2 (ANXA2) se ha hallado elevada en varios cánceres. Sin embargo, no hay datos disponibles de la expresión de esta proteína en los carcinomas epidermoides de cabeza y cuello. El objetivo de este estudio preliminar es investigar la expresión de la ANXA2 en estos carcinomas. Material y método: Se analizó la expresión de la ANXA2 mediante inmunohistoquímica en muestras incluidas en parafina de 9 lesiones premalignas y 21 carcinomas epidermoides de cabeza y cuello. Resultados: Todas las lesiones con displasia mostraron una reducción en la expresión de la ANXA2 respecto al tejido normal. En contraste, se apreció expresión de la ANXA2 en todos menos uno de los tumores estudiados. La disminución de la expresión de la ANXA2 en los carcinomas se correlacionó de forma significativa con una peor diferenciación histológica, con tumores de mayor tamaño y con metástasis ganglionares. Conclusiones: Nuestros datos muestran por primera vez que la ANXA2 se expresa en los carcinomas epidermoides de cabeza y cuello e indican que su expresión se relaciona con el grado de diferenciación de estos tumores

Objective: Over-expression of annexin A2 (ANXA2) has been reported in various cancers. However, no data are available on the expression of this protein in head and neck squamous cell carcinomas (HNSCC). The objective of this preliminary study is to investigate the expression of ANXA2 in these carcinomas. Material and method: ANXA2 expression was analyzed by immunohistochemistry in paraffin-embedded sections from 9 patients with premalignant lesions and 21 patients with HNSCC. Results: All dysplastic tissues showed significantly reduced ANXA2 expression compared to normal tissue. In contrast, ANXA2 expression was observed in all but one of the tumours studied. There was a significant correlation of lower ANXA2 expression with a poorer histological differentiation, larger tumours, and nodal metastases. Conclusions: Our data show for the first time that ANXA2 is expressed in head and neck squamous cell carcinomas and that its expression seems to be related with the degree of differentiation status of these tumours