RESUMO
We measured the effect of human growth hormone (hGH) on urea synthesis, nitrogen retention, and glucose turnover in ten euthyroid growth hormone (GH)-deficient children before and after seven daily injections of 0.1 U/kg hGH. The patients were fed a weight-maintaining diet with 9% of energy derived from protein. Following an overnight fast, urea synthesis and glucose turnover were determined using a primed constant infusion of [15N2] urea and a constant infusion of [6,6-2H2] glucose. Human growth hormone produced a decrease in urea nitrogen synthesis from 6.8 +/- 0.5 to 4.2 +/- 0.4 mg/kg.h; (P less than .01), while plasma urea nitrogen decreased from 13.1 +/- 0.8 to 7.4 +/- 0.8 mg/dL; (P less than .01). The decrease in urea synthesis was reflected in a corresponding decrease in urine urea nitrogen excretion (-2.8 mg/kg.h). There was a significant correlation between plasma urea nitrogen and urea synthesis rate both before (r = 0.85, P less than .01) and after (r = 0.79, P less than .01) hGH treatment. In response to hGH, there was a rise in both plasma glucose (81.4 +/- 2.2 v 89.8 +/- 2.3 mg/dL; P less than .05) and insulin (5.7 +/- 0.8 v 13.1 +/- 3.0 microU/mL; P less than .05), however, glucose turnover remained unchanged (4.7 +/- 0.3 v 4.6 +/- 0.6 mg/kg.min). After seven days of growth hormone treatment, the patients were placed on 0.1 U/kg of hGH three times a week for 6 months, and their growth rate was calculated.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Glucose/metabolismo , Hormônio do Crescimento/deficiência , Nitrogênio/metabolismo , Ureia/biossíntese , Glicemia/análise , Nitrogênio da Ureia Sanguínea , Criança , Jejum , Feminino , Crescimento/efeitos dos fármacos , Hormônio do Crescimento/administração & dosagem , Hormônio do Crescimento/sangue , Humanos , Insulina/sangue , MasculinoAssuntos
Hipotireoidismo/tratamento farmacológico , Hiperplasia do Timo/etiologia , Criança , Diagnóstico Diferencial , Feminino , Radioisótopos de Gálio , Humanos , Neoplasias do Mediastino/diagnóstico , Mediastino/diagnóstico por imagem , Cintilografia , Hiperplasia do Timo/diagnóstico , Hiperplasia do Timo/diagnóstico por imagem , Tiroxina/uso terapêutico , Tri-Iodotironina/uso terapêuticoAssuntos
Hiperplasia Suprarrenal Congênita/diagnóstico , Líquido Amniótico/imunologia , Esteroide 21-Hidroxilase , Esteroide Hidroxilases , Células Cultivadas , Citotoxicidade Imunológica , Feminino , Imunofluorescência , Antígenos HLA/genética , Teste de Histocompatibilidade , Humanos , Masculino , GravidezRESUMO
Congenital adrenal hyperplasia (C.A.H.) due to 21-hydroxylase deficiency is an HLA-linked recessive disorder. HLA-A and B antigens are expressed on amniotic cells. Prenatal diagnosis of C.A.H. by HLA typing of families and amniotic cells was attempted in two at-risk families. In one family HLA typing indicated that the fetus would have C.A.H., and this prediction was confirmed after birth. In the second family, HLA typing indicated that the fetus would be an unaffected, phenotypically normal carrier of the disease gene, and this prediction was also confirmed after birth.
Assuntos
Hiperfunção Adrenocortical/diagnóstico , Líquido Amniótico/imunologia , Antígenos HLA/análise , Oxigenases de Função Mista/deficiência , Diagnóstico Pré-Natal , Hiperfunção Adrenocortical/genética , Líquido Amniótico/citologia , Células Cultivadas , Feminino , Triagem de Portadores Genéticos , Genótipo , Antígenos HLA/genética , Teste de Histocompatibilidade , Humanos , Recém-Nascido , Masculino , Oxigenases de Função Mista/genética , Gravidez , Segundo Trimestre da GravidezRESUMO
A Brother and sister are presented with the following abnormalities: dolichocephaly with tendency toward premature closure of the sagittal suture; antimongoloid slant of the eyes with epicanthal folds, full cheeks, everted lip, multiple oral frenula, mildly high-arched palate, and microdontia with possible enamel defect; posteriorly rotated low-set pinnae with deficient cartilage; a small short thorax with pectus excavatum; unusual dermatoglyphics, and abnormal hair growth and stucture; disproportionate shortening of the fibulae and the middle and distal phalanges of the toes and fingers; and somewhat flattened epiphyses. A paternal aunt gave birth to a stillborn dwarfed male with some of the same clinical features. Although an autopsy was obtained, unfortunately no roentgenograms were made.