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1.
J Eur Acad Dermatol Venereol ; 27(8): 990-6, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22774979

RESUMO

BACKGROUND: Treatment of facial lipoatrophy of HIV/AIDS patients is mandatory by law in Brazil due to its negative impact on their quality of life. The index for facial lipoatrophy (ILA) is used as one of the inclusion criteria for patient treatment. OBJECTIVES: To define a correct diagnosis and staging of facial lipoatrophy, by employing the ILA. PATIENTS AND METHODS: This is an observational study of a series of case reports from patients submitted to facial lipoatrophy evaluation through ILA and treated with polymethylmethacrylate (PMMA) fillers. Facial lipoatrophy was classified in grades from I to IV, corresponding to mild, moderate, severe and very severe stage, according to ILA. Response to the treatment was defined as excellent (≥ 91%), good (71-90%), moderate (51-70%) and insufficient (≤ 50%). RESULTS: A total of 20 patients were included in this study: 18 men and two women. Median age was 49 years (35-61) and average ILA was 9.9 (7.2-16.8). Ten patients presented facial lipoatrophy grade II (moderate), 5 grade III (severe) and 5 grade IV (very severe). The average volume of PMMA used was 13 mL (5.5-22 mL). All patients showed good or excellent response, with a median of 86% (74-100%). The most typical adverse effect was local oedema but there were no late adverse effects. CONCLUSION: The ILA is an excellent method for evaluation of facial lipoatrophy and also for the assessment of the response to therapy. Facial filling with PMMA showed efficacy and safety in the treatment of facial lipoatrophy in HIV/AIDS patients.


Assuntos
Face , Infecções por HIV/complicações , Lipodistrofia/patologia , Polimetil Metacrilato/uso terapêutico , Adulto , Feminino , Humanos , Lipodistrofia/etiologia , Lipodistrofia/terapia , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Resultado do Tratamento
2.
Eur J Clin Microbiol Infect Dis ; 30(10): 1257-65, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21544695

RESUMO

Although curable, leprosy requires better diagnostic and prognostic tools to accompany therapeutic strategies. We evaluated the serum samples of leprosy patients from Venezuela and Brazil for reactivity against the specific recombinant proteins, ML0405 and ML2331, and the LID-1 fusion protein that incorporates both of these antigens. Antigen-specific IgG was highest in lepromatous leprosy patients (LL) and decreased across the disease spectrum, such that only a small subset of true tuberculoid patients (TT) tested positive. The impact of multidrug therapy (MDT) on these antibody responses was also examined. Several years after treatment, the vast majority of Venezuelan patients did not possess circulating anti-LID-1, anti-ML0405, and anti-ML2331 IgG, and the seropositivity of the remaining cases could be attributed to irregular treatment. At discharge, the magnitude and proportion of positive responses of Brazilian patients against the proteins and phenolic glycolipid (PGL)-I were lower for most of the clinical forms. The monthly examination of IgG levels in LL patient sera after MDT initiation indicated that these responses are significantly reduced during treatment. Thus, responses against these antigens positively correlate with bacillary load, clinical forms, and operational classification at diagnosis. Our data indicate that these responses could be employed as an auxiliary tool for the assessment of treatment efficacy and disease relapse.


Assuntos
Anticorpos Antibacterianos/sangue , Monitoramento de Medicamentos/métodos , Imunoglobulina G/sangue , Hanseníase/diagnóstico , Antibacterianos/uso terapêutico , Antígenos de Bactérias , Brasil , Humanos , Hanseníase/tratamento farmacológico , Estudos Longitudinais , Proteínas Recombinantes , Recidiva , Fatores de Tempo , Resultado do Tratamento , Venezuela
4.
Br J Dermatol ; 160(2): 311-8, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19187345

RESUMO

BACKGROUND: Comorbidity from tegumentary leishmaniasis and AIDS is poorly characterized. OBJECTIVES: To describe a series of patients coinfected with Leishmania and human immunodeficiency virus (HIV). METHODS: Clinical records from patients were analysed by demographic data, clinical manifestations, diagnoses, treatments and outcomes. RESULTS: Fifteen cases of AIDS/tegumentary leishmaniasis were found. The diagnosis of leishmaniasis was confirmed by the detection of Leishmania amastigotes or antigens from the cutaneous or mucosal lesions. The mean CD4+ T-cell count was 84 cells mm(-3) (range 8-258) and all patients were classified as having AIDS according to the Centers for Disease Control and Prevention. A wide range of manifestations was found, varying from a single ulcer to multiple and polymorphic lesions. Mucosal lesions were present in 80% and cutaneous lesions in 73% of patients (53% with mucocutaneous form), disseminated lesions in 60% and genital lesions in 27% of patients. All patients received anti-Leishmania therapy and 53% showed relapses. Sixty-seven per cent received highly active antiretroviral therapy but showed no difference in outcomes and relapses compared with those not using medication. Forty per cent died during the study period. In these patients, the anti-Leishmania antibody and Montenegro skin test were useful in the diagnosis of leishmaniasis, probably because leishmaniasis preceded immunosuppression due to HIV infection. CONCLUSIONS: Clinical manifestations of tegumentary leishmaniasis in HIV-infected patients are diverse. Our data emphasize possible unusual manifestations of this disease in HIV-infected patients, particularly in severely immunosuppressed cases (< 200 CD4+ cells mm(-3)).


Assuntos
Infecções Oportunistas Relacionadas com a AIDS/patologia , HIV-1 , Leishmaniose Cutânea/patologia , Mucosa/patologia , Infecções Oportunistas Relacionadas com a AIDS/imunologia , Adulto , Contagem de Linfócito CD4 , Diagnóstico Diferencial , Métodos Epidemiológicos , Feminino , HIV-1/imunologia , Humanos , Hospedeiro Imunocomprometido , Leishmaniose Cutânea/imunologia , Masculino , Pessoa de Meia-Idade , Mucosa/imunologia
5.
Rev. Soc. Bras. Med. Trop ; 39(supl. 1): 133-133, mar. 2006.
Artigo em Português | Sec. Est. Saúde SP, SESSP-IIERPROD, Sec. Est. Saúde SP | ID: biblio-1066737
8.
J Immunol ; 153(12): 5782-9, 1994 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-7527449

RESUMO

IL-10 has been shown to be capable of down-regulating several aspects of macrophage function. This study was undertaken to define the association between IL-10 and HIV-1 infection in human macrophages. Infection of macrophages with a monocytotropic strain of the human immunodeficiency virus, HIV-BaL, resulted in expression of IL-10 mRNA within 3 to 12 h after infection, as determined by the reverse transcriptase PCR. Biologically active IL-10 was detected in supernatants from HIV-1-infected macrophages as early as 12 h post-infection. The addition of human rIL-10 to HIV-1-infected macrophage cultures resulted in a significant decrease in the viral replication. In addition, exogenous IL-10 blocked the ability of TNF-alpha to elevate viral replication. To determine whether IL-10 was associated with in vivo infection, lymph nodes from AIDS patients were examined for the presence of IL-10 mRNA by using PCR. IL-10 mRNA was evident in all lymph node tissue examined, but was absent in normal lymph node biopsies. These in vitro and in vivo findings demonstrate a strong and heterogeneous association between HIV-1 infection and IL-10.


Assuntos
Infecções por HIV/imunologia , HIV-1/imunologia , Interleucina-10/fisiologia , Macrófagos/virologia , Replicação Viral/imunologia , Síndrome da Imunodeficiência Adquirida/imunologia , Adulto , HIV-1/fisiologia , Humanos , Interleucina-10/biossíntese , Pessoa de Meia-Idade , RNA Mensageiro/biossíntese , DNA Polimerase Dirigida por RNA/metabolismo , Fator de Necrose Tumoral alfa/antagonistas & inibidores
9.
Rev Hosp Clin Fac Med Sao Paulo ; 48(4): 170-4, 1993.
Artigo em Português | MEDLINE | ID: mdl-8284588

RESUMO

Lyme disease is an infectious disease caused by spirochete Borrelia burgdorferi transmitted by Ixodid tick bite. The geographic distribution of the disease is universal, but the disease has not been identified definitely in South America yet. We report a probable case of Lyme disease in a woman, living in Jaguaré slum (São Paulo), who showed characteristics skin lesions of erythema chronicum migrans, with fever, weakness, headache, muscular pain, cough, arthralgia and sensitive radicular neuropathy in the left arm. The sequential serology made by ELISA method, using Borrelia burgdorferi whole sonicated antigen from Dr. Allen C. Steere laboratory, showed high titers of IgM antibody (1:1600). Because of the persistence of high IgM response for two months, we decided to treat the patient with tetracycline 2g/day during 10 days and the sorology became negative two months. The western blotting confirmed ELISA results showing presence of five bands (IgM). This report fulfills CDC criteria for Lyme disease diagnosis.


Assuntos
Doença de Lyme/diagnóstico , Adulto , Anticorpos Antibacterianos/análise , Brasil , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Immunoblotting , Doença de Lyme/imunologia , Doença de Lyme/fisiopatologia
10.
An. bras. dermatol ; 57(1): 31-4, 1982.
Artigo em Português | LILACS | ID: lil-7285

RESUMO

Os autores apresentam um caso de lipodistrofia congenita em mulher adulta, com ausencia de gordura no subcutaneo, diabetes resistente a insulina, aspecto acromegaloide, aparente hipertrofia muscular, hiperlipemia hipertricose, profusao abdominal e lesoes de acanthosis nigricans, com alteracoes laboratoriais de glicemia de jejum, triglicerides, lipidograma, insulina plasmatica em jejum, hormonio de crescimento, testosterona plasmatica e alteracoes radiologicas


Assuntos
Diabetes Mellitus , Lipodistrofia , Acantose Nigricans
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