1.
Org Biomol Chem
; 21(8): 1653-1656, 2023 02 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36723220
RESUMO
The stereo-controlled total synthesis of (-)-domoic acid is described. The critical construction of the C1'-C2' Z-configuration was accomplished by taking advantage of an unsaturated lactam structure. The side chain fragment was introduced in the final stages of synthesis through a modified Julia-Kocienski reaction, aiming for its efficient derivatization.