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Downregulation of gene expression in hypoxic cancer cells by an activatable G-quadruplex stabiliser.
Chem Commun (Camb)
; 59(16): 2247-2250, 2023 Feb 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36723070
RESUMO
In the research, the modulation of gene expression with a novel G-quadruplex stabiliser was analysed. Activation by the removal of bulky hypoxia-responsive substituent enhances G-quadruplex stabilisation. Hypoxic MCF7 cells incubated with the stabiliser displayed significant downregulation of oncogenes c-myc, bcl-2, and hif-1α. This study presents the first hypoxia-activatable G-quadruplex stabilization and transcriptional regulation.