Perceived Stress Is Directly Associated with Major Consumption of Sugar-Sweetened Beverages among Public University Students.

Stress is a condition that has been related to the development of risk behaviors for health such as sugar-sweetened beverages (SSBs) consumption. The aim of this study was to examine the link between SSBs consumption and perceived stress level in university students. This was an observational, cross-sectional and single-time-point study where the subjects were recruited as a non-probabilistic sample of first-year university students. The students reported their SSBs consumption through a validated questionnaire, as well as their perceived stress level, evaluated through the Cohen scale. Comparisons were made between the means of all variables. Factorial analysis of variance was conducted to explore the effect of the variables' interaction on the stress level. One-way analysis of variance was performed to assess differences between the sexes. Men consumed more SSBs (6101.17 ± 3772.50 mL/week) compared to women (4294.06 ± 3093.8 mL/week). However, women had higher scores of perceived stress and showed a strong association of stress with the SSBs consumption pattern (r and p-value). This study shows for the first time the association that exists between stress and SSBs consumption and indicates that it is related to sex in the young population.

Brain radiotoxicity-related 15CAcBRT gene expression signature predicts survival prognosis of glioblastoma patients.

BACKGROUND: Glioblastoma is the most common and devastating primary brain cancer. Radiotherapy is standard of care; however, it is associated with brain radiation toxicity (BRT). This study used a multi-omics approach to determine whether BRT-related genes (RGs) harbor survival prognostic value and whether their encoded proteins represent novel therapeutic targets for glioblastoma. METHODS: RGs were identified through analysis of single-nucleotide variants associated with BRT (R-SNVs). Functional relationships between RGs were established using Protein-Protein Interaction networks. The influence of RGs and their functional groups on glioblastoma prognosis was evaluated using clinical samples from the Glioblastoma Bio-Discovery Portal database and validated using the Chinese Glioma Genome Atlas dataset. The identification of clusters of radiotoxic and putative pathogenic variants in proteins encoded by RGs was achieved by computational 3D structural analysis. RESULTS: We identified the BRT-related 15CAcBRT molecular signature with prognostic value in glioblastoma, by analysis of the COMT and APOE protein functional groups. Its external validation confirmed clinical relevance independent of age, MGMT promoter methylation status, and IDH mutation status. Interestingly, the genes IL6, APOE, and MAOB documented significant gene expression levels alteration, useful for drug repositioning. Biological networks associated with 15CAcBRT signature involved pathways relevant to cancer and neurodegenerative diseases. Analysis of 3D clusters of radiotoxic and putative pathogenic variants in proteins coded by RGs unveiled potential novel therapeutic targets in neuro-oncology. CONCLUSIONS: 15CAcBRT is a BRT-related molecular signature with prognostic significance for glioblastoma patients and represents a hub for drug repositioning and development of novel therapies.

Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico.

Few studies have addressed how selective pressures have shaped the genetic structure of the current Native American populations, and they have mostly limited their inferences to admixed Latin American populations. Here, we searched for local adaptation signals, based on integrated haplotype scores and population branch statistics, in 325 Mexican Indigenous individuals with at least 99% Native American ancestry from five previously defined geographical regions. Although each region exhibited its own local adaptation profile, only PPARG and AJAP1, both negative regulators of the Wnt/ß catenin signaling pathway, showed significant adaptation signals in all the tested regions. Several signals were found, mainly in the genes related to the metabolic processes and immune response. A pathway enrichment analysis revealed the overrepresentation of selected genes related to several biological phenotypes/conditions, such as the immune response and metabolic pathways, in agreement with previous studies, suggesting that immunological and metabolic pressures are major drivers of human adaptation. Genes related to the gut microbiome measurements were overrepresented in all the regions, highlighting the importance of studying how humans have coevolved with the microbial communities that colonize them. Our results provide a further explanation of the human evolutionary history in response to environmental pressures in this region.

Impacto del COVID-19 en la salud reproductiva: mortalidad materna / Impact of COVID-19 on reproductive health: maternal mortality / Impacto da COVID-19 na saúde reprodutiva: mortalidade materna

El presente artículo tiene como propósito analizar los efectos e impacto de la pandemia COVID-19 en la mortalidad materna de Perú, lo cual afectó la disponibilidad de recursos, equipos, demanda y acceso a los servicios de salud; se agrega el desvío de los recursos humanos, financieros para combatir el brote de la enfermedad infecciosa, el retraso de normas, políticas e insuficiente presupuesto público, fragmentación, desarticulación de los prestadores de salud y vulnerabilidad de los profesionales de salud. Es una investigación de enfoque cualitativo descriptivo y crítico, analizado en el aspecto social y económico de la mortalidad materna, datos epidemiológicos, normas técnicas, y la afectación del COVID-19 en la población gestante. Se analizó el incremento de la mortalidad materna de 45.4% y 56% el año 2020 y 2021 con respecto al año 2019, asimismo el logro alcanzado al 2015 a 68 muertes maternas y una disminución notable de 50% entre el año 2000 y 2019, para sucumbir por la pandemia en un retroceso de 12 años y convertirse la enfermedad COVID-19 en la tercera y primera causa de muerte materna indirecta el año 2020 y 2021. Destacando la aplicación de estrategias que tuvo la Región Lima, como una de las regiones con menor incidencia de 2 y 6 muertes maternas respectivamente. Ante esta problemática se concluyó la priorización de la capacidad resolutiva del primer nivel de atención, capacitación continua del profesional obstetra y la aplicación de estrategias promovidas por la Región Lima.

The purpose of this article is to analyze the effects and impact of the COVID-19 pandemic on maternal mortality in Peru, which affected the availability of resources, equipment, demand and access to health services; in addition to the diversion of human and financial resources to combat the outbreak of the infectious disease, the delay of standards, policies and insufficient public budget, fragmentation, disarticulation of health providers and vulnerability of health professionals. It is a qualitative descriptive and critical research approach, analyzed in the social and economic aspect of maternal mortality, epidemiological data, technical norms, and the affectation of COVID-19 in the pregnant population. The increase in maternal mortality of 45.4% and 56% in 2020 and 2021 with respect to 2019 was analyzed, also the achievement reached in 2015 to 68 maternal deaths and a remarkable decrease of 50% between 2000 and 2019, to succumb to the pandemic in a setback of 12 years and become the disease COVID-19 in the third and first cause of indirect maternal death in 2020 and 2021. It is worth highlighting the implementation of strategies that had the Lima Region as one of the regions with the lowest incidence of 2 and 6 maternal deaths respectively. In view of this problem, it was concluded that priority should be given to the capacity of the first level of care, continuous training of obstetricians and the application of strategies promoted by the Lima Region.

O objetivo deste artigo é analisar os efeitos e o impacto da pandemia COVID-19 na mortalidade materna no Peru, que afetou a disponibilidade de recursos, equipamentos, demanda e acesso a serviços de saúde; além do desvio de recursos humanos e financeiros para combater o surto da doença infecciosa, o atraso das normas, políticas e orçamento público insuficiente, a fragmentação, a desarticulação dos provedores de saúde e a vulnerabilidade dos profissionais de saúde. É uma abordagem de pesquisa qualitativa, descritiva e crítica, analisando os aspectos sociais e econômicos da mortalidade materna, dados epidemiológicos, padrões técnicos e o impacto da COVID-19 sobre a população grávida. Foi analisado o aumento da mortalidade materna de 45,4% e 56% em 2020 e 2021 em relação a 2019, bem como a conquista alcançada em 2015 para 68 mortes maternas e uma diminuição notável de 50% entre 2000 e 2019, para sucumbir à pandemia em um retrocesso de 12 anos e se tornar a doença COVID-19 na terceira e primeira causa de morte materna indireta em 2020 e 2021. A implementação de estratégias na Região de Lima foi destacada como uma das regiões com menor incidência de 2 e 6 mortes maternas, respectivamente. Diante deste problema, concluiu-se que deveria ser dada prioridade à capacidade do primeiro nível de atendimento, ao treinamento contínuo dos obstetras e à aplicação das estratégias promovidas pela Região de Lima.

MicroRNA delivery systems in glioma therapy and perspectives: A systematic review.

Gliomas are the deadliest of all primary brain tumors, and they constitute a serious global health problem. MicroRNAs (miRNAs) are gene expression regulators associated with glioma pathogenesis. Thus, miRNAs represent potential therapeutic agents for treating gliomas. However, miRNAs have not been established as part of the regular clinical armamentarium. This systemic review evaluates current molecular and pre-clinical studies with the aim of defining the most appealing supramolecular platform for administering therapeutic miRNA to patients with gliomas. An integrated analysis suggested that cationic lipid nanoparticles, functionalized with octa-arginine peptides, represent a potentially specific, practical, non-invasive intervention for treating gliomas. This supramolecular platform allows loading both hydrophilic (miRNA) and hydrophobic (anti-tumor drugs, like temozolomide) molecules. This systemic review is the first to describe miRNA delivery systems targeted to gliomas that integrate several types of molecules as active ingredients. Further experimental validation is warranted to confirm the practical value of miRNA delivery systems.

Recordemos lo importante que es la lactancia en México / Let's Remember the Importance of Breastfeeding

Resumen La lactancia materna se considera una estrategia primordial en la promoción de la salud y prevención de la enfermedad. En este documento se abordan aspectos que hacen evidente la importancia de la lactancia materna para la salud de la madre y su hijo, y el papel de los profesionales de la salud para promover, proteger y apoyar la lactancia materna. Se presenta un panorama epidemiológico de la lactancia en México, los principales constituyentes de la leche, los beneficios de amamantar, tanto para el bebé como para la madre, las barreras y mitos que de alguna manera influyen en la lactancia materna, los principales problemas de la lactancia materna y cómo resolverlos, los pasos propuestos y la técnica para lograr una lactancia exitosa y promover una cultura de lactancia materna.

Abstract Breastfeeding is considered a primary strategy in health promotion and disease prevention. This document addresses aspects that make evident the importance of breastfeeding for the health of the mother and her child, and the role of health professionals to promote, protect and support breastfeeding. An epidemiological panorama of breastfeeding in Mexico is presented, the main constituents of milk, the benefits of breastfeeding, both for the baby and for the mother, the barriers and myths that somehow influence breastfeeding, the main problems of breastfeeding and how to solve them, the proposed steps and the technique to achieve successful breastfeeding and promote a culture of breastfeeding.

Neck circumference cut-offs for overweight and obesity in a group of Mexican adolescents.

BACKGROUND/OBJECTIVES: Neck circumference (NC) has been used for screening overweight/obesity for its high correlation with age, weight, body mass index (BMI), and waist circumference (WC). Cut-offs should be population specific. The aim of the study was to obtain cut-offs of NC for overweight/obesity in Mexican adolescents and to correlate them with anthropometric indicators. SUBJECTS/METHODS: Weight, height, BMI, NC, WC, and mid-upper arm circumference (MUAC) of 465 12-14-year-old Mexican-mestizo students attending a public school in Mexico City were assessed. Using receiver operating characteristics analyses, neck cut-offs were obtained according to the WHO age and sex criteria for overweight/obesity. RESULTS: NC cut-offs with the highest sensitivity and specificity for males and females, respectively, were as follows: 30.0 and 29.3 cm for 12-year-olds; 31.9 and 30.4 cm for 13-year-olds; and, 33.5 and 30.7 cm for 14-year-old adolescents. Overweight/obesity was identified with NC cut-offs in 80% of males and 86% of females, and showed significant correlations (p < 0.01) in males and females with weight (r = 0.821 and r = 0.840, respectively), BMI (r = 0.649 and r = 0.819, respectively), WC (r = 0.710 and r = 0.813, respectively) and MUAC (r = 0.736 and r = 0.815, respectively). CONCLUSIONS: Neck circumference may be used as a first-stage screening tool or jointly with BMI to identify overweight/obesity in 12-14-year-old Mexican adolescents.

Consenso de hemofilia en México / Mexican Consensus in Haemophilia

resumen está disponible en el texto completo

Abstract Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B). Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity. Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles and elbows). This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion transmitted infections) or secondary to articular hemorrhagic events (hemophilic arthropathy). Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology charachterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia.

Repermeabilización portal intrahepática luego de ligadura de rama derecha de vena porta: reporte de un caso / Intrahepathic portal revascularization following right portal vein ligation: a case report / Repermeabilização portal intra-hepática após ligadura do ramo direito da veia porta: relato de caso

Resumen: La ligadura de una rama de la vena porta constituye un procedimiento con buenos resultados para evitar la falla hepática posoperatoria en caso de hepatectomías extremas al provocar la hipertrofia del hígado contralateral. Sin embargo, la repermeabilización de ésta ha sido demostrada por la presencia de anastomosis porto portales intrahepáticas, pudiendo determinar una disminución de la hipertrofia esperada o necesaria. Como objetivo documentamos un caso clínico de repermeabilización intrahepática de la vena porta, evento no deseado de la hepatectomía en dos tiempos para el tratamiento de metástasis hepáticas bilobares de origen colorrectal y describimos alternativas para evitar o tratar dicha repermeabilización.

Summary: Left or right portal vein ligation to prevent post-operative liver failure in the case of extreme hepatectomy constitutes a procedure with a good prognosis, as it causes contralateral liver hypertrophy. However, its revascularization has been proved by intrahepatic porto-portal anastomoses, which could result in a reduction of the expected or required hypertrophy. The study aims to record a clinical case of intrahepatic revascularization of the portal vein, an unwanted event of the two-stage hepatectomy to treat bilobar hepatic metastasis of colorectal origin, and describe alternatives to avoid or treat such revascularization.

Resumo: A ligadura de um ramo da veia porta é um procedimento com bons resultados para evitar a insuficiência hepática pós-operatória em hepatectomias extremas por causar hipertrofia do fígado contralateral. No entanto, sua repermeabilização tem sido demonstrada pela presença de anastomose porto-portal intra-hepática, que pode determinar diminuição da hipertrofia esperada ou necessária. Como objetivo, documentamos um caso clínico de repermeabilização da veia porta intra-hepática, um evento indesejado de hepatectomia em dois estágios para o tratamento de metástases hepáticas bilobares de origem colorretal, e descrevemos alternativas para evitar ou tratar essa repermeabilização.

Antibiotic resistance profile in intrahospital pediatric services at third level centers in Dominican Republic / Perfil de resistencia a antibióticos en servicios pediátricos intrahospitalarios en centros de tercer nivel en República Dominicana

Objectives: The Dominican Republic lacks reliable information on antimicrobial resistance (AMR), which would allow physicians to prescribe the best treatment for common infectious diseases. This study aimed to define the antimicrobial resistance profiles of the more common pathogens from pediatric services, where data is even more important due to the vulnerability of the population. Methods: We collected data from patients admitted in the pediatric unit of three third level hospitals in the city of Santiago de los Caballeros, Dominican Republic, showing positive bacterial cultures, during a period of two years. Results: Half of the Gram negative pathogens exhibited third generation cephalosporins (3GC) resistance, 17% were resistant to carbapenems. Serratia marcescens presented an exceptionally high proportion of resistance to 3GC (95.9%). Staphylococcus aureus showed elevated resistance to methicillin (58.4%) and even to clindamycin (35.8%). Conclusion: There are elevated levels of antimicrobial resistance among the Enterobacteriaceae family and the Staphylococcus genus isolated from the pediatric population. Necessary measures should be taken to tackle AMR in the country.

Objetivos: La República Dominicana carece de información confiable sobre las resistencias antimicrobianas en el país, lo que permitiría al personal médico prescribir los mejores tratamientos para infecciones comunes. El objetivo de este estudio es definir los perfiles de resistencia antimicrobiana de los patógenos más comunes en servicios pediátricos, donde esta información es esencial, debido a la vulnerabilidad de la población. Métodos: Se tomaron los datos de reportes microbiológicos con cultivo bacteriano positivo procedentes de pacientes admitidos en la unidad pediátrica de tres hospitales de tercer nivel en la ciudad de Santiago de los Caballeros, República Dominicana, durante un periodo de dos años. Resultados: La mitad de los patógenos Gram negativos mostraron resistencia a cefalosporinas de tercera generación (3GC), 17% eran resistentes a carbapenémicos. Serratia marcescens presentó una resistencia excepcionalmente elevada a 3GC (95.9%). Staphylococcus aureus mostró alta resistencia a meticilina (58.4%) e incluso a clindamicina (35.8%). Conclusión: Existen elevados niveles de resistencia antimicrobiana entre las enterobacterias y los estafilococos en la población pediátrica dominicana. Es necesario tomar medidas para abordar este problema en el país.

Validation of an evaluation instrument for responders in tactical casualty care simulations.

OBJECTIVE: to construct and validate a tool for the evaluation of responders in tactical casualty care simulations. METHOD: three rubrics for the application of a tourniquet, an emergency bandage and haemostatic agents recommended by the Hartford Consensus were developed and validated. Validity and reliability were studied. Validation was performed by 4 experts in the field and 36 nursing participants who were selected through convenience sampling. Three rubrics with 8 items were evaluated (except for the application of an emergency bandage, for which 7 items were evaluated). Each simulation was evaluated by 3 experts. RESULTS: an excellent score was obtained for the correlation index for the 3 simulations and 2 levels that were evaluated (competent and expert). The mean score for the application of a tourniquet was 0.897, the mean score for the application of an emergency bandage was 0.982, and the mean score for the application of topical haemostats was 0.805. CONCLUSION: this instrument for the evaluation of nurses in tactical casualty care simulations is considered useful, valid and reliable for training in a prehospital setting for both professionals who lack experience in tactical casualty care and those who are considered to be experts.

Validation of an evaluation instrument for responders in tactical casualty care simulations / Validação de um instrumento de avaliação para a prática de cuidados de saúde estratégicos / Validación de un instrumento de evaluación para la práctica de la atención sanitaria táctica

Objective: to construct and validate a tool for the evaluation of responders in tactical casualty care simulations. Method: three rubrics for the application of a tourniquet, an emergency bandage and haemostatic agents recommended by the Hartford Consensus were developed and validated. Validity and reliability were studied. Validation was performed by 4 experts in the field and 36 nursing participants who were selected through convenience sampling. Three rubrics with 8 items were evaluated (except for the application of an emergency bandage, for which 7 items were evaluated). Each simulation was evaluated by 3 experts. Results: an excellent score was obtained for the correlation index for the 3 simulations and 2 levels that were evaluated (competent and expert). The mean score for the application of a tourniquet was 0.897, the mean score for the application of an emergency bandage was 0.982, and the mean score for the application of topical haemostats was 0.805. Conclusion: this instrument for the evaluation of nurses in tactical casualty care simulations is considered useful, valid and reliable for training in a prehospital setting for both professionals who lack experience in tactical casualty care and those who are considered to be experts.

Objetivo: construir e validar um instrumento de avaliação da prática, por meio da simulação, nos cuidados de saúde estratégicos. Método: três instrumentos para práticas de avaliação de aplicação do torniquete, bandagem de emergência e agente hemostático recomendados pelo Consenso de Hartford foram desenvolvidos e validados. A validade e a confiabilidade foram estudadas. A validação foi realizada por quatro especialistas da área e trinta e seis enfermeiros participantes selecionados por amostragem por conveniência. Três instrumentos de avaliação com 8 itens foram avaliados (com exceção da bandagem de emergência, que tinha 7 itens para avaliar). Cada prática foi avaliada por três especialistas. Resultados: uma pontuação excelente foi obtida no cálculo do índice de correlação para as três práticas e nos dois níveis avaliados (competente e especialista). A pontuação média para a aplicação do torniquete foi de 0,897, para o curativo de emergência foi de 0,982 e para a aplicação de agentes hemostáticos tópicos foi de 0,805. Conclusão: este instrumento de avaliação da prática por meio de simulação nos cuidados de saúde estratégicos é considerado útil, válido e confiável para o treinamento no contexto pré-hospitalar tanto dos profissionais que não possuem experiência nos cuidados estratégicos quanto nos considerados peritos.

Objetivo: construir y validar un instrumento de evaluación de la práctica, mediante simulación, en la atención sanitaria táctica. Método: se construyeron y validaron tres rúbricas de las prácticas de aplicación del torniquete, vendaje de emergencia y agente hemostático recomendadas por el Consenso Hartford. Se estudió la validez y fiabilidad. La validación se realizó por cuatro expertos en la materia y treinta y seis participantes enfermeros que fueron la muestra de conveniencia. Se evaluaron tres rúbricas con 8 ítems (excepto para el vendaje de emergencia que fueron 7 ítems a evaluar). Cada práctica fue evaluada por tres expertos. Resultados: se ha obtenido una excelente puntuación en el cálculo del índice de correlación para las tres prácticas y en los dos niveles evaluados (competente y experto). La puntuación media para la rúbrica de aplicación del torniquete fue de 0.897, la del vendaje de emergencia 0.982 y para la aplicación de hemostáticos tópicos 0.805. Conclusión: este instrumento de evaluación de la práctica mediante simulación en la atención sanitaria se considera útil, válido y fiable para la formación en el entorno prehospitalario tanto de profesionales que carecen de experiencia en atención táctica como de aquellos considerados como expertos.

Factores socioambientales en el neurodesarrollo de trillizos prematuros. Reporte de un caso / Social and environmental factors of premature triplets' neurodevelopment. Case report

Resumen La epidemia de nacimientos prematuros es fruto de la compleja interacción entre los factores genéticos, sociales y ambientales. Gracias a los avances tecnológicos, la supervivencia de prematuros de menor edad y peso se ha incrementado, así como el riesgo de las secuelas que ello puede provocar. Este trabajo busca caracterizar los factores ambientales y sociales que pueden afectar el neurodesarrollo; el análisis se realizó en un modelo de intervención temprana en el Instituto Nacional de Pediatría (INP). Se presenta el reporte de un caso de embarazo múltiple asistido donde los factores genéticos y ambientales fueron similares, con diferencias en los factores biológicos, así como la interacción de la díada y su evolución en el neurodesarrollo durante el primer año de vida.

Abstract The premature birth epidemic is the result of genetic, social and environmental complex interactions. As smaller and lower-weight children survive, sequelae increase. This paper characterizes the environmental and social factors related to neurodevelopment as a component of an early intervention program at the National Pediatrics Institute. We present the case report of an assisted multiple pregnancy with similar genetic and environmental factors, but biologic and dyadic interaction differences, and report the neurodevelopmental evolution over the first year of life.

Estándares para las Convivencias cubanas de niños y adolescentes con diabetes / Standards for residential weeks for diabetic children and adolescents in Cuba

Introducción: las Convivencias para niños y adolescentes con diabetes mellitus tipo 1 surgen en Cuba en el año 1993, como una alternativa para la educación diabetológica; desde entonces, se realizan en la mayoría de las provincias del país. Objetivo: estandarizar la organización y realización de las Convivencias para niños y adolescentes con diabetes mellitus tipo 1. Desarrollo: durante una semana se adiestran a los pacientes y sus familiares (por separado) en el manejo integral de la diabetes mellitus tipo 1. Las Convivencias combinan las actividades educativas con la evaluación clínica del paciente, por lo que incluye además el monitoreo glucémico diario, el ajuste del tratamiento, la realización de complementarios, así como la evaluación por diferentes especialidades. La estandarización ofrece los detalles del proceso, los horarios y lugares recomendados para cada actividad, las técnicas educativas según los grupos de edades, y las técnicas para la evaluación de la actividad. Conclusión: las Convivencias constituyen un proceder a la vez educativo, terapéutico y recreativo, que permite conocer no solo el estado de salud de los pacientes en general, sino también, la situación familiar existente alrededor del niño o adolescente que vive con diabetes. La acción holística de la convivencia resulta indispensable a fin de perfeccionar el tratamiento de la diabetes; así como, optimizar la calidad de vida de los pacientes que la padecen(AU)

Introduction: the residential weeks for children and adolescents with type 1 diabetes mellitus emerge in Cuba in 1993 as an alternative for education on diabetes; since then, they are held in most provinces. Objective: to standardize the organization and holding of the residential weeks for children and adolescents with type 1 diabetes mellitus. Development: during a week, the patients and their relatives (separately) are trained in the comprehensive management of type 1 diabetes mellitus. Residential weeks combine the educational activities with the clinical evaluation of the patient, so they include daily glycemic monitoring, adjustment of treatment, the performance of supplementary tests as well as their evaluation by different specialties. Standardization offers the details of the process, the recommended schedules and places for each activity, the educational techniques by age groups and the evaluation techniques of the activity.Conclusions: the residential week represents an educational, therapeutic and recreational procedure that allows knowing not only the health status of the patient but also the existing family situation of the child and the adolescent living with diabetes. The holistic action of the residential week is indispensable to improve the diabetes treatment as well as to optimize the quality of life of patients suffering it(AU)

Estándares para las Convivencias cubanas de niños y adolescentes con diabetes / Standards for residential weeks for diabetic children and adolescents in Cuba

Introducción: las Convivencias para niños y adolescentes con diabetes mellitus tipo 1 surgen en Cuba en el año 1993, como una alternativa para la educación diabetológica; desde entonces, se realizan en la mayoría de las provincias del país. Objetivo: estandarizar la organización y realización de las Convivencias para niños y adolescentes con diabetes mellitus tipo 1. Desarrollo: durante una semana se adiestran a los pacientes y sus familiares (por separado) en el manejo integral de la diabetes mellitus tipo 1. Las Convivencias combinan las actividades educativas con la evaluación clínica del paciente, por lo que incluye además el monitoreo glucémico diario, el ajuste del tratamiento, la realización de complementarios, así como la evaluación por diferentes especialidades. La estandarización ofrece los detalles del proceso, los horarios y lugares recomendados para cada actividad, las técnicas educativas según los grupos de edades, y las técnicas para la evaluación de la actividad. Conclusión: las Convivencias constituyen un proceder a la vez educativo, terapéutico y recreativo, que permite conocer no solo el estado de salud de los pacientes en general, sino también, la situación familiar existente alrededor del niño o adolescente que vive con diabetes. La acción holística de la convivencia resulta indispensable a fin de perfeccionar el tratamiento de la diabetes; así como, optimizar la calidad de vida de los pacientes que la padecen(AU)

Introduction: the residential weeks for children and adolescents with type 1 diabetes mellitus emerge in Cuba in 1993 as an alternative for education on diabetes; since then, they are held in most provinces. Objective: to standardize the organization and holding of the residential weeks for children and adolescents with type 1 diabetes mellitus. Development: during a week, the patients and their relatives (separately) are trained in the comprehensive management of type 1 diabetes mellitus. Residential weeks combine the educational activities with the clinical evaluation of the patient, so they include daily glycemic monitoring, adjustment of treatment, the performance of supplementary tests as well as their evaluation by different specialties. Standardization offers the details of the process, the recommended schedules and places for each activity, the educational techniques by age groups and the evaluation techniques of the activity. Conclusions: the residential week represents an educational, therapeutic and recreational procedure that allows knowing not only the health status of the patient but also the existing family situation of the child and the adolescent living with diabetes. The holistic action of the residential week is indispensable to improve the diabetes treatment as well as to optimize the quality of life of patients suffering it(AU)

Avaliação linfocintilográfica qualitativa de pacientes com linfedema de membros inferiores tratados com compressão pneumática intermitente por quatro semanas / Qualitative lymphoscintigraphic evaluation of patients with lower limb lymphedema, treated with sequential intermittent pneumatic compression for four weeks

Introdução: O tratamento conservador do linfedema periférico consta de drenagem linfática manual, exercícios terapêuticos, contenção elástica e inelástica e também a compressão pneumática intermitente sequencial. Objetivo: Avaliar o efeito da compressão pneumática intermitente sequencial associada ao uso de contenção inelástica e elástica e exercícios miolinfocinéticos, durante quatro semanas, em pacientes com linfedema das extremidades inferiores, utilizando a análise qualitativa da linfocintilografia e a perimetria. Material e métodos: Dez pacientes portadores de linfedema das extremidades inferiores selecionados por conveniência, totalizando 14 membros acometidos, foram submetidos a quatro semanas de tratamento com compressão pneumática intermitente sequencial, contenção inelástica e elástica e exercícios miolinfocinéticos. Para a avaliação dos membros realizou-se a análise qualitativa da linfocintilografia e também a perimetria dos membros antes e após o tratamento proposto. Resultados: Não foi encontrada diferença estatisticamente significativa nos achados linfocintilográficos pré e pós-tratamento. Contudo, encontrou-se redução significativa da perimetria dos membros (p < 0,01) cuja redução máxima encontrada foi de 5,9% na perimetria do tornozelo e a mínima de 1,8% na perimetria da coxa. Conclusão: O tratamento realizado foi eficaz na redução da perimetria do membro tratado, porém não foi observada alteração significativa nos padrões linfocintilográficos qualitativos para estes pacientes. (AU)

Introduction: Conservative treatment of peripheral lymphedema consists of manual lymphatic drainage, therapeutic exercises, elastic and inelastic compression and sequential intermittent pneumatic compression. Objective: The objective of this study was to evaluate the effect of four weeks of sequential intermittent pneumatic compression combined with elastic and inelastic compression and lymphokinetic exercises on patients with lymphedema of the lower extremities by means of qualitative analysis with lymphoscintigraphy and circumference measurements. Methods: Ten people with lymphedema of the lower limbs, totaling 14 limbs treated, selected by convenience, underwent lymphoscintigraphy before and after four weeks of treatment with sequential intermittent pneumatic compression, elastic and inelastic sleeves and lymphokinetic exercises. For evaluating limbs, were carried out qualitative analysis of lymphoscintigraphy and also circumference measurements before and after the proposed treatment. Results: No statistically significant differences were detected in lymphoscintigraphic findings before and after treatment. However, there was a significant reduction in the circumference measurements (p <0.01) of the limbs. The maximum reduction was found 5.9% in the ankle circumference and the minimum was 1.8% thigh circumference. Conclusion: The treatment was effective at reducing limb circumference, however, no significant changes were observed on the qualitative lymphoscintigraphic analysis for these patients. (AU)

'Candidatus Liberibacter asiaticus', Causal Agent of Citrus Huanglongbing, Is Reduced by Treatment with Brassinosteroids.

Huanglongbing (HLB) constitutes the most destructive disease of citrus worldwide, yet no established efficient management measures exist for it. Brassinosteroids, a family of plant steroidal compounds, are essential for plant growth, development and stress tolerance. As a possible control strategy for HLB, epibrassinolide was applied to as a foliar spray to citrus plants infected with the causal agent of HLB, 'Candidatus Liberibacter asiaticus'. The bacterial titers were reduced after treatment with epibrassinolide under both greenhouse and field conditions but were stronger in the greenhouse. Known defense genes were induced in leaves by epibrassinolide. With the SuperSAGE technology combined with next generation sequencing, induction of genes known to be associated with defense response to bacteria and hormone transduction pathways were identified. The results demonstrate that epibrassinolide may provide a useful tool for the management of HLB.

Current imaging follow-up of non-Hodgkin lymphoma exposes patients to significant radiation but does not detect asymptomatic relapses.

The standard approach to the follow-up of lymphoma includes computed tomography (CT) every 6-12 months for the first 2 years and, then, as clinically indicated. Recent evidence suggests that most relapses are detected clinically, outside scheduled CT which, on the other hand, increases risk of second malignancies and cost. In early-stage lymphomas, involved site CT instead of full body CT may be a reasonable alternative to reduce radiation dose. We analyzed whether regular CT surveillance detects asymptomatic relapses in a single-center Uruguayan early stage non-Hodgkin lymphoma (NHL) population. We evaluated utility of full body CT halfway and at the end-of-treatment evaluation and calculated the radiation exposure. In our study, CT surveillance added nothing to clinical follow-up. Moreover, 44% of our patients received a cumulative effective dose that doubles the risk of malignancies. Involved-site CT scan would be enough to monitor response during treatment in early stage NHL.

Avaliação da postura e dos movimentos articulares dos membros superiores de pacientes pós-mastectomia e linfadenectomia / Assessment of posture and joint movements of the upper limbs of patients after mastectomy and lymphadenectomy

OBJETIVO: Avaliar as alterações posturais e de amplitudes de movimento de membro superior nas mulheres pós-mastectomia e linfadenectomia que se submeteram à radioterapia como tratamento adjuvante. MÉTODOS: Foram avaliados dois grupos: 16 mulheres pós-mastectomia com linfedema de membro superior e 14 mulheres pós-mastectomia sem linfedema. As pacientes foram submetidas à avaliação feita por programas computadorizados, um para postura e outro para medir as amplitudes de movimento de ombro, cotovelo e punho. Os resultados obtidos foram comparados entre lado direito e esquerdo, e operado e não operado, sendo submetidos a testes estatísticos. RESULTADOS: Ambos os grupos apresentaram anteriorização de tronco. As mulheres com linfedema mostraram rotação de cabeça à direita, protusão de ombro do lado esquerdo e medidas do ângulo de talhe menores do lado operado, além de elevação da escápula bilateralmente, quando comparadas ao grupo sem linfedema. As alterações de amplitude de movimento também foram menores do lado operado na flexão, abdução e rotação externa de ombro para todas as mulheres e, para aquelas que tinham linfedema, a extensão de cotovelo e a flexão de punho tiveram menor amplitude de movimento. CONCLUSÃO: Mulheres que foram submetidas à mastectomia apresentaram assimetrias e alterações de postura, e o linfedema parece agravar essa condição. Além disso, apresentaram déficits de amplitude de movimento em ombros, do lado operado. Mulheres com linfedema exibiram também déficits em cotovelo e punho.

OBJECTIVE: To evaluate alterations in posture and range of motion of the upper limbs in women after mastectomy and lymphadenectomy, submitted to radiotherapy as adjuvant treatment. METHODS: Two groups were evaluated: 16 post-mastectomy women with lymphedema of the upper limb and 14 post-mastectomy women without lymphedema. Patients were submitted to analysis made by software, one for posture and the other to measure ranges of movement of the shoulder, elbow, and wrists. The results obtained were compared between the right and left sides, and operated and non-operated sides, and then were submitted to statistical tests. RESULTS: Both groups presented with anteriorization of the trunk. The women with lymphedema had head rotation to the right, protrusion of the left shoulder, and trunk inclination angle smaller on the operated side, besides bilateral elevation of the scapula when compared to the group with no lymphedema. Changes in range of motion were also smaller on the operated side in terms of flexion, abduction, and external rotation of the shoulder for all women, and for those with lymphedema, elbow extension and wrist flexion had a smaller range of motion. CONCLUSION: Women submitted to mastectomy presented with asymmetries and modifications in posture, and lymphedema seemed to worsen this condition. Additionally, they had deficits in range of motion in the shoulders on the operated side. Women with lymphedema also showed deficits in the elbows and wrist.

Assessment of posture and joint movements of the upper limbs of patients after mastectomy and lymphadenectomy.

OBJECTIVE: To evaluate alterations in posture and range of motion of the upper limbs in women after mastectomy and lymphadenectomy, submitted to radiotherapy as adjuvant treatment. METHODS: Two groups were evaluated: 16 post-mastectomy women with lymphedema of the upper limb and 14 post-mastectomy women without lymphedema. Patients were submitted to analysis made by software, one for posture and the other to measure ranges of movement of the shoulder, elbow, and wrists. The results obtained were compared between the right and left sides, and operated and non-operated sides, and then were submitted to statistical tests. RESULTS: Both groups presented with anteriorization of the trunk. The women with lymphedema had head rotation to the right, protrusion of the left shoulder, and trunk inclination angle smaller on the operated side, besides bilateral elevation of the scapula when compared to the group with no lymphedema. Changes in range of motion were also smaller on the operated side in terms of flexion, abduction, and external rotation of the shoulder for all women, and for those with lymphedema, elbow extension and wrist flexion had a smaller range of motion. CONCLUSION: Women submitted to mastectomy presented with asymmetries and modifications in posture, and lymphedema seemed to worsen this condition. Additionally, they had deficits in range of motion in the shoulders on the operated side. Women with lymphedema also showed deficits in the elbows and wrist.