RESUMO
It is known the presence of receptors for the morphine products on the Lymphocytes B. These receptors could have a modulator action on the production of antibodies in drug addicts. We have determined the existence of IgG anti-HSV I in saliva and serum in a heroin population. Our results show that here is not significant differences between the heroin population and the control group, when the antibodies are detected in serum. But significant differences do exist between the number of people with antibodies anti-HSV I in saliva.
Assuntos
Anticorpos Anti-Idiotípicos/análise , Dependência de Heroína/imunologia , Simplexvirus/imunologia , Adulto , Anticorpos Antivirais/análise , Humanos , Imunoglobulina G/imunologia , Saliva/análise , Saliva/imunologiaRESUMO
The possible development of a displacement interaction involving tolbutamide, in epileptic patients, has been explored by studying the serum protein binding of this drug in vitro in 199 samples of sera from patients treated with antiepileptic agents included in a programme of therapeutic drug monitoring. 82 of the samples were from patients receiving a single drug, 86 from patients treated with 2 drugs, and 31 from patients treated with 3 drugs. The free fraction of tolbutamide was higher in serum from patients treated with antiepileptic drugs than in serum from untreated 'normal' volunteers. The increase was more marked the greater the number of antiepileptic drugs administered. Valproate appeared to be the most powerful displacing agent.
Assuntos
Anticonvulsivantes/efeitos adversos , Proteínas Sanguíneas/metabolismo , Tolbutamida/sangue , Adolescente , Adulto , Anticonvulsivantes/sangue , Ligação Competitiva , Criança , Clonazepam/farmacologia , Interações Medicamentosas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fenobarbital/farmacologia , Fenitoína/farmacologia , Ligação Proteica , Ácido Valproico/farmacologiaRESUMO
Gentamicin therapy was monitored in 30 patients with severe infection and other concomitant disease states. The application of the nomogram of Hull and Sarubbi [6] produced good plasma levels and disappearance of the infective agent without evidence of drug toxicity in 70% of patients. The remaining 30% did not respond satisfactorily to the treatment and showed low drug serum concentrations; and them had heavy fluid losses; when we modified their treatment, outside of the nomogram guidelines, we observed a better response. Since gentamicin distributes essentially in extracellular water, subjects who have alterations of body fluids regulation should be carefully controlled.
