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2.
J Food Sci ; 86(12): 5329-5339, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34730233

RESUMO

This research analyzed the influence of fat content (1%, 3%, 5%, and 10%, w.b.) and of water activity (0.85, 0.90, 0.95, and 0.99) on the effectiveness of microwave heating within model systems (agar gel). Findings indicate that an increased fat content promotes more uniform heating in the model systems and results in longer heating times to reach the target temperature of 50°C. In the model systems with different aw values, the warming of the central model zone was slower while in the corners, heating was accelerated. Additionally, in these models, heating times increased as the aw was decreased. PRACTICAL APPLICATION: The study of model systems allows for a detailed assessment of food when subjected to microwaves; and how heating is influenced by food properties such as aw and fat content. Findings indicate that changes in product formulation could improve the heating of ready-to-eat foods, either by increasing the fat content (better uniformity) or having high aw (shorter heating time).


Assuntos
Calefação , Micro-Ondas , Alimentos , Temperatura , Água
3.
Transplant Proc ; 50(2): 539-542, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29579846

RESUMO

INTRODUCTION: Ischemia reperfusion injury (IRI) is the main cause of early allograft dysfunction (EAD) and subsequent primary allograft failure (PAF). OBJECTIVES: The purpose of this study is to compare IRI, EAD, and PAF in liver transplantation in a cohort of patients perfused with histidine-tryptophan-ketoglutarate (HTK) solution and University of Wisconsin (UW) solution versus HTK alone. METHODS: A randomized trial was performed to compare outcomes in liver recipients who underwent transplantation surgery in the University Regional Hospital of Malaga, Spain. Forty patients were randomized to two groups. Primary endpoints included IRI, EAD, PAF, re-intervention, acute cellular rejection, retransplantation, arterial complications, and biliary complications at postoperative day 90. RESULTS: Postoperative glutamic oxaloacetic transaminase (1869.15 ± 1559.75 UI/L vs. 953.15 ± 777.27 UI/L; P = .004) and glutamic pyruvic transaminase (1333.60 ± 1115.49 U/L vs. 721.70 ± 725.02 U/L; P = .023) were significantly higher in patients perfused with HTK alone. A clear tendency was observed in recipients perfused with HTK alone to present moderate to severe IRI (7 patients in the HTK + UW solution group vs. 15 patients in the HTK-alone solution group; P = .06), EAD (0 patients in the HTK + UW solution group vs. 0 patients in the HTK-alone solution group; P = .76), and PAF (3 patients in the HTK + UW solution group vs. 8 patients in the HTK-alone solution group; P = .15). CONCLUSIONS: Initial perfusion with HTK solution followed by UW solution in liver transplantation improves early liver function as compared to perfusion with HTK alone.


Assuntos
Transplante de Fígado/métodos , Soluções para Preservação de Órgãos/administração & dosagem , Perfusão/métodos , Adenosina/administração & dosagem , Adenosina/efeitos adversos , Adulto , Alanina Transaminase/sangue , Alopurinol/administração & dosagem , Alopurinol/efeitos adversos , Aspartato Aminotransferases/sangue , Estudos de Coortes , Quimioterapia Combinada , Feminino , Glucose/administração & dosagem , Glucose/efeitos adversos , Glutationa/administração & dosagem , Glutationa/efeitos adversos , Rejeição de Enxerto/induzido quimicamente , Humanos , Insulina/administração & dosagem , Insulina/efeitos adversos , Fígado , Masculino , Manitol/administração & dosagem , Manitol/efeitos adversos , Pessoa de Meia-Idade , Soluções para Preservação de Órgãos/efeitos adversos , Perfusão/efeitos adversos , Período Pós-Operatório , Cloreto de Potássio/administração & dosagem , Cloreto de Potássio/efeitos adversos , Procaína/administração & dosagem , Procaína/efeitos adversos , Rafinose/administração & dosagem , Rafinose/efeitos adversos , Reoperação , Traumatismo por Reperfusão/induzido quimicamente , Espanha , Resultado do Tratamento
4.
Ginecol Obstet Mex ; 66: 69-71, 1998 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-9586391

RESUMO

The pregnancy increases the risk of cardiovascular ischemic events, The longitudinal sinus thrombosis is very rare, but the incidence increases during pregnancy and puerperium. The mortality rates range from 25% to 50%. This report consists of a case which was studied and managed at the Military Central Hospital. It occurred on the 12th day post C-S. The diagnostic was confirmed by MRI. The treatment consisted of rest and heparin with a successful development. Our findings agreed with the studies reported at the literature that suggested a beneficial effect with the heparin's use, lowering drastically the mortality rates. Some still oppose to its use because of the risk of an intracranial hemorrhage.


Assuntos
Transtornos Puerperais , Trombose dos Seios Intracranianos , Adulto , Anticoagulantes/uso terapêutico , Cesárea , Feminino , Fibrinolíticos/uso terapêutico , Heparina/uso terapêutico , Humanos , Imageamento por Ressonância Magnética , Transtornos Puerperais/diagnóstico , Transtornos Puerperais/tratamento farmacológico , Trombose dos Seios Intracranianos/diagnóstico , Trombose dos Seios Intracranianos/tratamento farmacológico , Varfarina/uso terapêutico
5.
Psychopharmacology (Berl) ; 116(4): 428-32, 1994 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-7701044

RESUMO

Cocaethylene (the ethyl ester of benzoylecgonine) is a product of the interaction between ethanol and cocaine. The results of preclinical studies and of a pilot clinical study have shown cocaethylene to produce pharmacologic effects similar to those of cocaine. However, no information is available concerning the potency and pharmacokinetics of cocaethylene in comparison to those of cocaine in humans. We report the results of a single-blind, crossover study in which six male, healthy, paid volunteers, who were moderate users of cocaine, were intravenously injected with the water soluble fumarate salt of cocaethylene (0.25 mg/kg cocaethylene base) or an equivalent dose of the water soluble hydrochloride salt of cocaine (0.25 mg/kg cocaine base). Each dose was dissolved in normal saline and injected over a 1-min interval. Test sessions were separated by a 1-week interval. The variables measured were: cocaine and cocaethylene plasma concentrations, subjective and cardiovascular effects. The results indicate, that in comparison to cocaine, cocaethylene had a significant smaller elimination rate constant (0.42 versus 0.67 l/h), had a longer elimination half-life (1.68 versus 1.07 h), and induced ratings of "high" and changes in heart rate that were of lower magnitude (65%, and 43%, respectively). During the period of time that pharmacologic effects were present the plasma concentrations of cocaine and cocaethylene were statistically indistinguishable. This finding supports the conclusion that in humans cocaethylene is less potent than cocaine.


Assuntos
Cocaína/análogos & derivados , Inibidores da Captação de Dopamina/farmacologia , Inibidores da Captação de Dopamina/farmacocinética , Adulto , Cocaína/administração & dosagem , Cocaína/farmacocinética , Cocaína/farmacologia , Estudos Cross-Over , Inibidores da Captação de Dopamina/administração & dosagem , Euforia/efeitos dos fármacos , Meia-Vida , Frequência Cardíaca/efeitos dos fármacos , Hemodinâmica/efeitos dos fármacos , Humanos , Injeções Intravenosas , Masculino , Método Simples-Cego
6.
J Comput Assist Tomogr ; 18(2): 269-71, 1994.
Artigo em Inglês | MEDLINE | ID: mdl-8126280

RESUMO

OBJECTIVE: We describe the MR appearance of endometriosis involving the umbilicus in two patients. One patient had a history of laparoscopy performed through the umbilicus; the other had an umbilical hernia. MATERIALS AND METHODS: MR imaging was performed using both a body coil and a spine coil (with the patient lying prone on the spine coil). The lesions were surgically removed and their MR appearance was correlated with the results of histologic analysis. RESULTS: The lesions were well delineated on MRI and showed evidence of prior hemorrhage consistent with endometriosis. Both lesions were shown to be endometriosis at surgical pathology. CONCLUSION: MR imaging was useful for delineating the size and location of the lesions and excluding intraabdominal extension.


Assuntos
Endometriose/diagnóstico , Imageamento por Ressonância Magnética , Umbigo/patologia , Adulto , Cicatriz/patologia , Endometriose/patologia , Feminino , Hérnia Umbilical/diagnóstico , Hérnia Umbilical/patologia , Humanos , Laparoscopia , Imageamento por Ressonância Magnética/métodos
7.
Life Sci ; 55(7): 541-50, 1994.
Artigo em Inglês | MEDLINE | ID: mdl-8041232

RESUMO

To investigate the pharmacologic effects of the interaction between cocaine and ethanol, six male, paid volunteers familiar with the use of both ethanol and cocaine were tested in a dose-response, placebo-controlled, single-blind, randomly-assigned, cross-over design. Cocaine HCl (1.25 and 1.9 mg/kg) or placebo (lidocaine and mannitol) was given by nasal insufflation (snorting). Thirty minutes after cocaine snorting, ethanol (0.85 g/kg) or placebo was administered in divided doses over a thirty minute period. Cocaine and cocaethylene plasma concentrations, blood ethanol levels, subjective ratings of drug effects, heart rate and blood pressure were measured. Statistical analysis of the effects of cocaine snorting before ethanol ingestion indicate that: 1) cocaine did not alter the blood ethanol levels or the ratings of ethanol intoxication; 2) cocaethylene was formed and appeared in plasma more slowly and in concentrations lower than those of its parent compound; 3) the appearance of cocaethylene in plasma did not alter the decline of cocaine's subjective and heart rate effects; and 4) cocaine plasma concentrations were not increased and no augmentation of the subjective and heart rate effects of cocaine occurred. This latter finding, is in sharp contrast to the significant increase in cocaine plasma concentration and augmentation of cocaine's subjective and heart rate effects produced when ethanol is ingested prior to cocaine snorting.


Assuntos
Cocaína/administração & dosagem , Etanol/administração & dosagem , Administração por Inalação , Pressão Sanguínea/efeitos dos fármacos , Cocaína/análogos & derivados , Cocaína/sangue , Cocaína/farmacologia , Esquema de Medicação , Interações Medicamentosas , Etanol/sangue , Etanol/farmacologia , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Valores de Referência
9.
Drug Metab Dispos ; 21(4): 717-23, 1993.
Artigo em Inglês | MEDLINE | ID: mdl-8104133

RESUMO

S-(+)-methamphetamine hydrochloride ("ice") is abused by smoking (inhaling the vapors of the material). Male human volunteers inhaled the drug from a pipe heated at 300 degrees-305 degrees C for an average inhaled dose of 21.8 +/- 0.3 (SE) mg. The same volunteers were given an intravenous injection of 15.5 mg of S-(+)-methamphetamine hydrochloride. Methamphetamine and its metabolite amphetamine were analyzed in plasma, saliva, and urine by gas chromatography. The bioavailability of smoked methamphetamine was 90.3 +/- 10.4%. (Oral bioavailability calculated from this study and a previous one was 67.2 +/- 3.1%). The geometric mean plasma half-life was 11.1 hr for smoked methamphetamine and 12.2 hr for the intravenous drug. These values agreed with urinary excretion rate data. The volume of distribution in the elimination phase was 3.24 +/- 0.36 liter/kg for the smoked dose and 3.73 +/- 0.59 liter/kg for the intravenous dose. The mean residence times were 11.5 +/- 0.5 hr and 11.3 +/- 1.74 hr for the two routes. Metabolic clearance represented 58 and 55%, respectively, of the total clearance. Significant amounts of the drug (37-45% of the nominal dose) were excreted in urine as methamphetamine and lesser amounts (7% of the nominal molar dose) as amphetamine. Renal clearance was equivalent for the two routes. Methamphetamine concentrations in plasma after inhalation showed a plateau. A model involving both a fast and a slow input function fit the data from 4 of the 6 subjects and indicated a terminal elimination rate that agreed with results from model-independent pharmacokinetic calculations. The drug caused significant subjective and cardiovascular effects.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Metanfetamina/farmacocinética , Administração por Inalação , Adulto , Líquidos Corporais/química , Sistema Cardiovascular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Testes de Função Cardíaca/efeitos dos fármacos , Humanos , Injeções Intravenosas , Masculino , Metanfetamina/administração & dosagem , Metanfetamina/sangue , Metanfetamina/urina , Autoadministração , Fumar
10.
Psychopharmacology (Berl) ; 113(1): 144-7, 1993.
Artigo em Inglês | MEDLINE | ID: mdl-7862821

RESUMO

Preclinical studies have shown cocaethylene (the ethyl ester of benzoylecgonine) to produce pharmacologic effects of similar magnitude to those of cocaine. These observations, however, cannot establish whether or not cocaethylene produces cocaine-like subjective effects. We report the results of experiments in which three healthy male, paid volunteers were intravenously injected with the water soluble fumarate salt of cocaethylene in escalating doses. Subjective effects and cardiovascular parameters were the dependent variables. The maximal dose of cocaethylene base administered (0.25 mg/kg) produced subjective effects that were judged as milder and tachycardic effects that were comparable to those produced by the intravenous injection of an equivalent dose (0.25 mg/kg) of cocaine base.


Assuntos
Cocaína/análogos & derivados , Inibidores da Captação de Dopamina/farmacologia , Hemodinâmica/efeitos dos fármacos , Adulto , Cocaína/administração & dosagem , Cocaína/farmacologia , Inibidores da Captação de Dopamina/administração & dosagem , Relação Dose-Resposta a Droga , Frequência Cardíaca/efeitos dos fármacos , Humanos , Injeções Intravenosas , Masculino , Método Simples-Cego
11.
Drug Metab Dispos ; 20(6): 856-62, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1362938

RESUMO

The pharmacokinetics of orally administered S-(+)-methamphetamine-d3 were investigated in human male volunteers before and after a 13-day course of a slow release form of S-methamphetamine hydrochloride. A one-compartment pharmacokinetic model incorporating a lag time fits the data best. The average elimination half-life was 10.1 hr (range of 6.4-15.1 hr). There were no statistically significant differences in pharmacokinetic parameters when a low dose (0.125 mg/kg) was given before and after the 13-day oral regimen. When a higher challenge dose (0.250 mg/kg) was used, the maximum plasma concentration of methamphetamine-d3 was slightly but significantly greater when the test dose was given at the end of the oral dosing period than when it was given at the beginning. Although minor differences in pharmacokinetics occur after subchronic treatment with low doses of methamphetamine, their result would be to increase plasma concentration of the drug. Therefore, development of pharmacodynamic tolerance to methamphetamine could not be explained on the grounds of a change in pharmacokinetics.


Assuntos
Metanfetamina/farmacocinética , Administração Oral , Adulto , Humanos , Rim/metabolismo , Masculino , Metanfetamina/administração & dosagem
12.
Alcohol Clin Exp Res ; 16(4): 769-75, 1992 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-1530141

RESUMO

The purpose of this study was to test the hypothesis that pretreatment with Ca2+ channel blockers would antagonize the effects of ethanol intoxication in humans. The Ca2+ channel blockers verapamil and nifedipine were chosen because preclinical research has shown them to decrease certain behavioral effects of ethanol in animals. Sixteen healthy, male, paid volunteers, moderate users of ethanol, participated in the study (six in the verapamil and 10 in the nifedipine paradigms). Gelatin capsules containing verapamil (80 mg, 160 mg, or placebo) were administered orally 90 min before ethanol ingestion; whereas, gelatin capsules containing nifedipine (10 mg, 20 mg, or placebo) were administered 30 min before ethanol ingestion. Ethanol (0.85 g/kg or placebo) was administered over a 30-min interval. Subjects were tested in a single-blind, latin-square, cross-over design with each of the following six conditions: placebo ethanol-placebo blocker, placebo ethanol-low dose blocker, placebo ethanol-high dose blocker, ethanol-placebo blocker, ethanol-low dose blocker, and ethanol-high dose blocker. The variables measured in this study were subjective rating of ethanol intoxication, Addiction Research Center Inventory alcohol scale, heart rate, blood pressure, short-term memory, accuracy and latency of response in the Simulator Evaluation of Drug Impairment task, and blood ethanol concentrations by breath analyzer. Results indicate that pretreatment with either verapamil or nifedipine failed to antagonize the inebriating effects of ethanol including its decremental effects on short-term memory and psychomotor performance.


Assuntos
Intoxicação Alcoólica/psicologia , Etanol/antagonistas & inibidores , Rememoração Mental/efeitos dos fármacos , Nifedipino/farmacologia , Desempenho Psicomotor/efeitos dos fármacos , Verapamil/farmacologia , Adulto , Relação Dose-Resposta a Droga , Etanol/farmacocinética , Humanos , Masculino
13.
Alcohol Clin Exp Res ; 16(1): 75-81, 1992 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-1558306

RESUMO

The objective of this study was to investigate the interaction between ethanol and dextroamphetamine with regard to psychomotor performance. Twelve healthy, male, paid volunteers, moderate users of ethanol and amphetamines, participated in this study. Ethanol (0.85 g/kg or placebo) was administered over a 30-min interval. Five minutes before the termination of ethanol or placebo ingestion, dextroamphetamine elixir (0.09 mg/kg, 0.18 mg/kg or placebo) diluted in 50 ml of orange juice was administered. Subjects were tested in a single-blind, latin-square, crossover design with each of the following six conditions: placebo ethanol/placebo dextroamphetamine; placebo ethanol/low-dose dextroamphetamine; placebo ethanol/high-dose dextroamphetamine; ethanol/placebo dextroamphetamine; ethanol/low-dose dextroamphetamine; and ethanol/high-dose dextroamphetamine. The variables measured in this study were: subjective rating of ethanol and dextroamphetamine intoxication, accuracy and latency of response in the Simulator Evaluation of Drug Impairment (SEDI task), blood ethanol concentration by breath analyzer, and plasma concentrations of dextroamphetamine by gas chromatography. Results indicate ethanol induced decrements in performance of the skills necessary to drive an automobile were significantly decreased by dextroamphetamine in a dose-response fashion. The administration of dextroamphetamine did not decrease the subjective ratings of ethanol intoxication.


Assuntos
Consumo de Bebidas Alcoólicas/psicologia , Dextroanfetamina/farmacologia , Desempenho Psicomotor/efeitos dos fármacos , Adulto , Consumo de Bebidas Alcoólicas/sangue , Intoxicação Alcoólica/sangue , Intoxicação Alcoólica/psicologia , Atenção/efeitos dos fármacos , Pressão Sanguínea/efeitos dos fármacos , Dextroanfetamina/farmacocinética , Relação Dose-Resposta a Droga , Interações Medicamentosas , Etanol/farmacocinética , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Método Simples-Cego
14.
Life Sci ; 51(8): 553-63, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1640806

RESUMO

To investigate the pharmacologic effects of the interaction between ethanol and cocaine, eleven male, paid volunteers familiar with the use of both ethanol and cocaine were tested in a dose-response, placebo-controlled, single-blind, randomly-assigned, cross-over design. Ethanol (0.85 g/kg) or placebo was administered in divided doses over a thirty minute period. Fifteen minutes after the termination of ethanol ingestion, cocaine HCl (1.25 and 1.9 mg/kg) or placebo (lidocaine and mannitol) was given by nasal insufflation (snorting). Cocaine and cocaethylene plasma concentrations, blood ethanol levels, subjective ratings of drug effects, and cardiovascular parameters were measured. Statistical analysis of the results indicate that: 1) cocaine administration did not alter blood ethanol concentrations nor the ratings of ethanol intoxication; 2) ethanol caused a significant increase in cocaine plasma concentrations, ratings of cocaine "high", and heart rate; 3) acute tolerance to the subjective and heart rate effects of cocaine was observed; 4) when combined with cocaine, ethanol led to the slow formation of cocaethylene in amounts much lower than those of its parent compound; and 5) the appearance of cocaethylene in plasma did not alter cocaine's subjective and cardiovascular effects.


Assuntos
Sistema Cardiovascular/efeitos dos fármacos , Cocaína/análogos & derivados , Cocaína/sangue , Cocaína/farmacologia , Etanol/farmacologia , Intoxicação Alcoólica/sangue , Relação Dose-Resposta a Droga , Interações Medicamentosas , Etanol/sangue , Humanos , Masculino , Valores de Referência , Método Simples-Cego , Transtornos Relacionados ao Uso de Substâncias/sangue
15.
Pharmacol Biochem Behav ; 40(3): 691-4, 1991 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-1666929

RESUMO

Six healthy male, paid volunteers smoked one NIDA cigarette containing 1.0% THC each day for 13 consecutive days. They were tested before and after the period of drug administration by the following procedure: the subjects smoked one NIDA marijuana cigarette containing 1.0% THC followed 15 minutes later by the intravenous infusion of 52 micrograms/min of deuterated THC for 50 minutes. The THC plasma concentrations, ratings of "high" and heart rate effects produced by the combined drug administration were measured, and absolute bioavailability of smoked THC was calculated on Days 1 and 22. Statistical analyses indicate that the only significant changes induced by daily marijuana exposure were in cardioacceleration.


Assuntos
Fumar Maconha/fisiopatologia , Adulto , Disponibilidade Biológica , Dronabinol/administração & dosagem , Dronabinol/farmacocinética , Dronabinol/farmacologia , Frequência Cardíaca/efeitos dos fármacos , Hemodinâmica/efeitos dos fármacos , Humanos , Injeções Intravenosas , Masculino , Fumar Maconha/psicologia
16.
Clin Neuropharmacol ; 14(4): 352-8, 1991 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-1913701

RESUMO

This study investigated alterations in the disposition and pharmacodynamics of methamphetamine HCl after daily administration. Six male paid volunteers familiar with the use of amphetamines participated. Each subject was administered 10 mg of methamphetamine HCl as a slow-release preparation (Desoxyn Gradumets) at 9 a.m. for 13 consecutive days (days 2-14 of the study). On days 1 and 15 the subjects were challenged with 10 mg of oral deuterated methamphetamine HCl. Deuterated drug was used to differentiate plasma concentrations of challenge doses from those of daily doses. The heart rate, subjective perception of "high," and plasma concentrations of methamphetamine were examined on days 1 and 15. Repeated ANOVA measures indicate that a significant decrease in heart-rate acceleration in response to methamphetamine challenge occurred on day 15 [F(1,5) = 8.26, p less than or equal to 0.035]. However, no significant change in either the subjective ratings of "high" or the plasma concentrations of deuterated methamphetamine occurred. These findings indicate that the disposition of methamphetamine and its subjective effects were not altered by this period of daily exposure to a low dose of the drug. In contrast, tolerance to the heart-rate accelerating effect was observed.


Assuntos
Metanfetamina/administração & dosagem , Adulto , Pressão Sanguínea/efeitos dos fármacos , Preparações de Ação Retardada , Esquema de Medicação , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Metanfetamina/sangue , Metanfetamina/farmacologia
17.
Life Sci ; 49(13): 953-9, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1886456

RESUMO

Despite the increasing popularity of crystalline methamphetamine ("ice") vapor inhalation, no investigations have reported drug plasma concentrations and effects. Under controlled laboratory conditions, six subjects were studied. Plasma concentrations of methamphetamine were determined, and subjective and cardiovascular effects were measured. Methamphetamine appeared in plasma rapidly, increased slowly over the next four hours and then progressively declined. The dose of methamphetamine administered produced modest ratings of subjective drug effects, and moderate changes in cardiovascular parameters. Both subjective and cardiovascular effects rapidly decreased despite the presence of sustained concentrations of methamphetamine in plasma.


Assuntos
Sistema Cardiovascular/efeitos dos fármacos , Metanfetamina/farmacologia , Administração por Inalação , Adulto , Pressão Sanguínea/efeitos dos fármacos , Débito Cardíaco/efeitos dos fármacos , Fenômenos Fisiológicos Cardiovasculares , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Metanfetamina/administração & dosagem , Metanfetamina/sangue , Volume Sistólico/efeitos dos fármacos , Fatores de Tempo
18.
Life Sci ; 48(6): 507-15, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1846934

RESUMO

To investigate whether the nonsteroidal anti-inflammatory drug (NSAID) indomethacin antagonized the effects of marihuana, an exploratory single-blind, placebo-controlled study was conducted. Subjects (n = 4) smoked marihuana after pre-treatment with placebo and indomethacin. The subjective rating of marihuana "high", heart rate, word recall, time estimation/production, and plasma concentrations of THC and PGE2 were measured. It was found that: 1) indomethacin pre-treatment decreased the elevation of prostaglandins induced by THC; 2) indomethacin significantly attenuated the subjective "high" and the heart rate accelerating effects of THC, although the magnitude of this effect was modest; 3) indomethacin abolished the profound effect of THC on time estimation and production; and 4) indomethacin pretreatment did not affect the decremental effects of THC on word recall. We conclude that prostaglandins are involved in the neurophysiologic mechanisms that mediate some of the typical clinical effects of THC, particularly the distortion of time perception.


Assuntos
Dronabinol/antagonistas & inibidores , Indometacina/farmacologia , Fumar Maconha/psicologia , Adulto , Dinoprostona/sangue , Dronabinol/sangue , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Fumar Maconha/fisiopatologia , Memória/efeitos dos fármacos , Fatores de Tempo
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