[Encephalopathy due to human herpesvirus 6 in a western immunocompetent patient]. / Encefalopatia por virus herpes humano de tipo 6 en una paciente inmunocompetente occidental.

TITLE: Encefalopatia por virus herpes humano de tipo 6 en una paciente inmunocompetente occidental.

Prevalence of Trypanosoma cruzi infection in pregnant Latin American women and congenital transmission rate in a non-endemic area: the experience of the Valencian Health Programme (Spain).

This study describes the results of the health programme implemented in the Valencian Community (Spain) to achieve an early diagnosis of Chagas disease in pregnant Latin American women and their newborns. During 2009 and 2010, 1975 women living in the health districts of three university hospitals were enrolled via midwives or at the time of delivery. Diagnosis of disease was performed using two serological tests with different antigens. Congenital infection was diagnosed by parasitological, molecular or serological methods from blood samples obtained at birth or in subsequent controls. The overall seroprevalence of Chagas infection in pregnant women from 16 different endemic countries was 11·4%. Infection was higher in those from countries in the Gran Chaco Region (Bolivia, 34·1%; Paraguay, 7·4%; Argentina, 5·3%). Eight newborn infants from Bolivian mothers had congenital Chagas which represents a vertical transmission rate of 3·7%. In conclusion, this work supports the benefits of offering an early diagnosis to pregnant women and newborns during routine prenatal healthcare.

Endocarditis neumocócica: revisión a propósito de un caso y nueva pauta de tratamiento asociada a fosfomicina / Pneumococcal endocarditis: report of a case involving a novel treatment with association of fosfomycin and a review of the literature

Se presenta un interesante caso de endocarditis bacteriana en un varón de 12 años de edad, que asociaba como patología de base una comunicación interventricular membranosa, que presentó buena respuesta al tratamiento asociado con penicilina en altas dosis, gentamicina y fosfomicina. Se adjunta una revisión bibliográfica acerca de los distintos tratamientos antibióticos descritos, incluidas las pautas menos habituales. Se incluye en la discusión una extensa explicación de la asociación al tratamiento antibiótico de fosfomicina

The authors present an interesting case of bacterial endocarditis in a 12 year-old boy, the underlying cause of which was a membranous ventricular septal defect. The infection responded well to treatment with high-dose penicillin, in combination with gentamycin and fosfomycin. A review of the literature dealing with the different types of antibiotic therapy, including less conventional approaches, is provided, and the reasons for administering combination treatment involving fosfomycin are explained in detail

Pielonefritis aguda con síntomas compatibles con artritis de cadera / Acute pyelonephritis with symptoms compatible with arthritis of the hip

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[Lumbosacral dermal sinus as entry point of purulent meningitis. Report of 3 cases]. / Seno dérmico lumbo-sacro como puerta de entrada de meningitis purulenta. Presentación de tres casos.

Defects of neural tube closure, although minimal, can provide access for infections of the central nervous system. All skin alterations in rear middle line of the body, however, minimal, must be carefully investigated as they could give access to bacterial meningitis. We present three new cases of dermal lumbosacral sinus which went unnoticed in the neonatal period later becoming the access point for bacterial meningitis.