RESUMO
Postoperative pain (POP) is a challenging clinical phenomenon that affects the majority of surgical patients and demands effective management to mitigate adverse outcomes such as persistent pain. The primary goal of POP management is to alleviate suffering and facilitate a seamless return to normal function for the patient. Despite compelling evidence of its drawbacks, opioid analgesia remains the basis of POP treatment. Novel therapeutic approaches rely on multimodal analgesia, integrating different pharmacological strategies to optimize efficacy while minimizing adverse effects. The recognition of the imperative role of the endocannabinoid system in pain regulation has prompted the investigation of cannabinoid compounds as a new therapeutic avenue. Cannabinoids may serve as adjuvants, enhancing the analgesic effects of other drugs and potentially replacing or at least reducing the dependence on other long-term analgesics in pain management. This narrative review succinctly summarizes pertinent information on the molecular mechanisms, clinical therapeutic benefits, and considerations associated with the plausible use of various cannabinoid compounds in treating POP. According to the available evidence, cannabinoid compounds modulate specific molecular mechanisms intimately involved in POP. However, only two of the eleven clinical trials that evaluated the efficacy of different cannabinoid interventions showed positive results.
Assuntos
Canabinoides , Manejo da Dor , Dor Pós-Operatória , Humanos , Dor Pós-Operatória/tratamento farmacológico , Canabinoides/uso terapêutico , Canabinoides/farmacologia , Manejo da Dor/métodos , Analgesia/métodos , Animais , Analgésicos/uso terapêutico , Analgésicos/farmacologia , Endocanabinoides/metabolismo , Endocanabinoides/uso terapêuticoRESUMO
El cuidado unificado de la episiotomía es fundamental para prevenir las complicaciones que surgen en el puerperio. Se analiza mediante un estudio clínico comparativo en dos grupos de mujeres primíparas, la evolución de la episiotomía en función de la aplicación de povidona yodada al 0,4 por ciento a través de ocho variables cualitativas analizadas de forma independiente. Por su mayor influencia en la evolución de la episiotomía se ha evaluado en profundidad una de las variables que definen su calidad: la dehiscencia. Del estudio se concluye que el fomento del autocuidado influye en una mejor evolución de la episiotomía con respecto a la aplicación del antiséptico (AU)
