Endothelin-Converting Enzyme 1 and Vascular Endothelial Growth Factor as Potential Biomarkers during Ex Vivo Lung Perfusion with Prolonged Hypothermic Lung-Sparing.

Lung transplantation requires optimization of donor's organ use through ex vivo lung perfusion (EVLP) to avoid primary graft dysfunction. Biomarkers can aid in organ selection by providing early evidence of suboptimal lungs during EVLP and thus avoid high-risk transplantations. However, predictive biomarkers of pulmonary graft function such as endothelin-converting enzyme (ECE-1) and vascular endothelial growth factor (VEGF) have not been described under EVLP with standard prolonged hypothermic preservation, which are relevant in situations where lung procurement is difficult or far from the transplantation site. Therefore, this study is aimed at quantifying ECE-1 and VEGF, as well as determining their association with hemodynamic, gasometric, and mechanical ventilatory parameters in a swine model of EVLP with standard prolonged hypothermic preservation. Using a protocol with either immediate (I-) or delayed (D-) initiation of EVLP, ECE-1 levels over time were found to remain constant in both study groups (p > 0.05 RM-ANOVA), while the VEGF protein was higher after prolonged preservation, but it decreased throughout EVLP (p > 0.05 RM-ANOVA). Likewise, hemodynamic, gasometric, mechanical ventilatory, and histological parameters had a tendency to better results after 12 hours of hypothermic preservation in the delayed infusion group.

[Factors relating to falls in hospitalized patients]. / Factores relacionados con la presencia de caídas en pacientes hospitalizados.

Falls are one indicator of quality, and are classified as an adverse event, where the consequences of these can range from mild to severe and even fatal; the Joint Commission International (JCI) reports them as the sixth most frequently reported event in the database Sentinel Events. A challenge for health institutions is to maintain a risk-free environment, ensuring users to achieve the expected improvement; however each hospital is extremely complex due to the constant interaction of the person with their environment, making it necessary to have clear understanding of the variables that can influence the situation. To consider a risk-free environment must be considered preventive actions to minimize risk factors, which can be both intrinsic and extrinsic, first includes the particular characteristics of the person, and the latter refers to the hospital environment. It is important to consider that within the intrinsic factors, although they cannot be completely modified, is necessary to make an assessment and identify risks to promote preventive measures, respect to the extrinsic; is responsibility of the multidisciplinary health team to identify and eliminate the causes that contribute to the presence of falls.

Evaluación de la capacitación de enfermería en dos institutos nacionales de salud / Nursing training assessment in two national institutes of health

Introducción: La capacitación de enfermería es un proceso permanente para adquirir, mantener, renovar, reforzar, actualizar e incrementar los conocimientos, es necesario conocer la opinión del personal respecto a la capacitación impartida por sus instituciones. Objetivo: Evaluar la capacitación del personal de enfermería de dos Institutos Nacionales de Salud. Material y métodos: Estudio observacional comparativo y transversal. La muestra fue aleatoria sistematizada (n=415 enfermeras del área operativa). Se midieron tres dimensiones: planeación, desarrollo y evaluación. Datos recolectados con instrumento ex profeso autoadministrado de 38 ítems sometido a prueba piloto y confiabilidad. Los datos se analizaron con frecuencias, porcentajes, medidas de tendencia central, pruebas T Student, ANOVA de una vía, correlación Pearson y Spearman tomando estadísticamente significativo p<0.05. Resultados: La capacitación es evaluada de buena a excelente en las tres categorías laborales y niveles académicos, excepto en las personas que tienen posgrado; el turno que mejor la evalúa es el vespertino (83.34%); el 80% del instituto A y 65% del instituto B evaluaron la capacitación de buena a excelente, lo que se asocia con el nivel académico (rs=0.175, p <0.0001); las especialistas evalúan mejor la planeación que las auxiliares (26.0 ± 7.80, F=4.357, gl=2, p<0.01). Discusión: Existe poca evidencia con la cual se puedan comparar los resultados; la mayoría evalúa la capacitación desde la perspectiva de la calidad, aprendizaje o conocimiento. Conclusiones: La evaluación general del proceso de capacitación es considerada por el personal de enfermería como adecuada, lo cual se refleja en la asistencia anual a cursos.

Introduction: Nursing training is a permanent process to acquire, maintain, renew, strengthen, update, and increment knowledge, and because of this, it is necessary to know the staff's opinion about the nursing training offered by their institutions. Objective: To assess the nursing staff training at two National Institutes of Health. Materials and methods: Observational, comparative and basic study. The sample was random and systematized (n = 415 nurses from the operative area). Three dimensions were measured: planning, development, and evaluation. Data were collected through a unique self-administered 38 items instrument which was used for a pilot test and further tested for its confidence level Data were analyzed through frequencies, percentages, central tendency measures, student T tests, one way ANOVA, and Pearson and Spearman correlations, having p < .05 as statistically significant. Results: The training is assessed as good-excellent in the three working categories and academic levels, except in the persons who have a post-degree; the shift which better evaluates it is the afternoon one (83.34%); 80°% from the Institute A and 65% from the Institute B assessed the training as good-excellent, a finding which is associated with academic level (rs=0.175, p <0.0001); specialists assess planning better than the auxiliary personnel (26.0 ± 7.80, F=4.357, gl=2, p<0.01). Discussion: There is little evidence to compare the results; the majority assess the training from the perspective of quality, learning or knowledge. Conclusions: the general assessment of the training process is considered by the nursing staff as adequate, a finding which reflects their assistance to yearly courses.