[Pulmonary fibrosis and endovesical mitomycin C]. / Mitomicina C endovesical y fibrosis pulmonar.

The Mitomycin C is a chemotherapeutic agent used in several types of carcinomas. In the superficial vesical carcinoma comes using since more than a quarter century in the form of endovesical instillations. It is a drug relatively safe, although there have been described adverse effects related to its systemic administration as myelosuppression, anaemia, kidney toxicity and less frequently pulmonary fibrosis. In this article we presented the case of a patient who suffers a respiratory illness compatible with interstitial lung disease that develops a respiratory severe insufficiency finishing with the death, after the administration of endovesical mitomycin C, being this adverse effect exceptional for this route of administration.

Mitomicina C endovesical y fibrosis pulmonar / Pulmonary fibrosis and endovesical Mitomycin C

La Mitomicina C es un agente quimioterápico usado en varios tipos de carcinomas. En el carcinoma vesical superficial se viene usando desde hace más de un cuarto de siglo en forma de instilaciones endovesicales. Se trata de un fármaco relativamente seguro, aunque se han descritos efectos adversos relacionados con su administración sistémica como la mielosupresión, anemia, toxicidad renal y con menor frecuencia fibrosis pulmonar. En este artículo presentamos el caso de un paciente que sufre un cuadro respiratorio compatible con enfermedad pulmonar intersticial que evolucionó hasta una insuficiencia respiratoria severa y éxitus tras la administración endovesical demitomicina C, siendo este efecto adverso excepcional para esta vía de administración (AU)

The Mitomycin C is a chemotherapeutic agent used in several types of carcinomas. In the superficial vesical carcinoma comes using since more than a quarter century in the form of endovesical instillations. It is a drug relatively safe, although there have been described adverse effects related to its systemic administration asmyelosuppression, anaemia, kidney toxicity and less frequently pulmonary fibrosis. In this article we presented the case of a patient who suffers a respiratory illness compatible with interstitial lung disease that develops a respiratory severe insufficiency finishing with the death, after the administration of endovesical mitomycin C, being this adverse effect exceptional for this route of administration (AU)

[Left renal atrophy and ureteral abouchement in seminal vesicle. Laparoscopic surgical treatment]. / Atrofia renal izquierda y abocamiento ureteral a vesícula seminal. Tratamiento quirúrgico laparoscópico.

Renal atrophy with an ectopic drainage of the ureter is an uncommon malformation. Zinder described in 1914 a cystic dilation of the seminal vesicle in association with an ipsilateral renal agenesis. Usually, these patients present lower urinary tract symptoms with perineal discomfort and fever. The most accurate diagnosis is given by the MRI, while CT and ultrasonography are less precise. We present a case of a patient who goes into hospital because of left lumbar pain and urinary sepsis data, whose CT detects an ectopic drainage of the left uereter in the seminal vesicle. He underwent a successful laparoscopic surgical treatment.

Atrofia renal izquierda y abocamiento ureteral a vesícula seminal. Tratamiento quirúrgico laparoscópico / Left renal atrophy and ureteral abouchement in seminal vesicle. Laparoscopic surgical treatment

La atrofia renal con abocamiento ectópico del uréter es una malformación poco frecuente. Zinder describe en 1914 la asociación de una dilatación quística de la vesícula seminal con agenesia renal ipsilateral. Con mayor frecuencia estos pacientes presentan síntomas del tracto urinario inferior con molestias perineales y fiebre. El diagnostico más certero lo aporta la RMN siendo la ecografía y la TAC menos precisas. Presentamos un caso de un paciente que ingresa por dolor lumbar izquierdo y datos de sepsis de origen urinario que en la TAC se detecta una desembocadura ectópica del uréter izquierdo en vesícula seminal. El tratamiento se realizó con éxito mediante cirugía laparoscópica (AU)

Renal atrophy with an ectopic drainage of the ureter is an uncommon malformation. Zinder described in 1914 a cystic dilation of the seminal vesicle in association with an ipsilateral renal agenesis. Usually, these patients present lower urinary tract symptoms with perineal discomfort and fever. The most accurate diagnosis is given by the MRI, while CT and ultrasonography are less precise. We present a case of a patient who goes into hospital because of left lumbar pain and urinary sepsis data, whose CT detects an ectopic drainage of the left uereter in the seminal vesicle. He underwent a successful laparoscopic surgical treatment (AU)

Modeling of mini-proinsulin production in Pichia pastoris using the AOX promoter.

An unstructured model based on mass balance equations for a recombinant methylotrophic yeast Pichia pastoris MutS (Methanol Utilization Slow) strain expressing the mini-proinsulin (MPI), was successfully established in quasi-steady state fed-batch fermentations with varying total quantity of biomass in a 7 l fermenter. The model describes the relationships between the total biomass and induction time, both in the batch and fed-batch phases. In addition, good correlations were obtained when the total quantity of MPI was correlated with the total biomass, demonstrating that the product of interest is associated with growth in the methanol phase. The parameters of the fermentation model obtained are similar to those reported by other researchers.