RESUMO
The ethanolic extract of Asparagus racemosus Willd. was evaluated for its inhibitory potential on lithiasis (stone formation), induced by oral administration of 0.75% ethylene glycolated water to adult male albino Wistar rats for 28 days. The ionic chemistry of urine was altered by ethylene glycol, which elevated the urinary concentration of crucial ions viz. calcium, oxalate, and phosphate, thereby contributing to renal stone formation. The ethanolic extract, however, significantly (p < 0.05) reduced the elevated level of these ions in urine. Also, it elevated the urinary concentration of magnesium, which is considered as one of the inhibitors of crystallization. The high serum creatinine level observed in ethylene glycol-treated rats was also reduced, following treatment with the extract. The histopathological findings also showed signs of improvement after treatment with the extract. All these observations provided the basis for the conclusion that this plant extract inhibits stone formation induced by ethylene glycol treatment.
Assuntos
Asparagus/química , Cálculos Renais/tratamento farmacológico , Rim/efeitos dos fármacos , Animais , Cálcio/urina , Creatinina/sangue , Etilenoglicol , Rim/metabolismo , Rim/patologia , Cálculos Renais/induzido quimicamente , Cálculos Renais/metabolismo , Magnésio/urina , Masculino , Oxalatos/urina , Fosfatos/urina , Extratos Vegetais/farmacologia , Raízes de Plantas/química , Ratos , Ratos WistarRESUMO
The effect of ethanolic extract of the root of Withania somnifera Dunal (REWS) against Dalton's Ascitic Lymphoma has been evaluated in Swiss albino mice. A significant increase in the life span and a decrease in the cancer cell number and tumour weight were noted in the tumour-induced mice after treatment with REWS. The hematological parameters were also corrected by REWS in tumour-induced mice. These observations are suggestive of the protective effect of REWS in Dalton's Ascitic Lymphoma (DAL).
