RESUMO
Rats treated with RNA from normal rat spleen were challenged 5 days later with Salmonella typhimurium. The primary response was delayed and antibody titers significantly lower than controls were observed. Forty eight hours after the secondary challenge the antibody titers were also lower; this difference disappeared five days later. This study confirms the immunological depression produced by RNA. Moreover, it is demonstrated that the RNA action is transitory and that the recovery of secondary response occurs seven days after the second challenge. This action is probably explained at macrophage level.
Assuntos
Anticorpos Antibacterianos/biossíntese , RNA/farmacologia , Salmonella typhimurium/imunologia , Animais , Feminino , RatosRESUMO
Rats treated with RNA from normal rat spleen were challenged 5 days later with Salmonella typhimurium. The primary response was delayed and antibody titers significantly lower than controls were observed. Forty eight hours after the secondary challenge the antibody titers were also lower; this difference disappeared five days later. This study confirms the immunological depression produced by RNA. Moreover, it is demonstrated that the RNA action is transitory and that the recovery of secondary response occurs seven days after the second challenge. This action is probably explained at macrophage level.
RESUMO
Se trataron intraperitonealmente ratas hembras con RNA obtenido de bazo de rata normal de la misma linea, las que se inocularon 5 dias mas tarde con Salmonella typhimurium. En la respuesta primaria se observo una demora significativa en la aparicion de los anticuerpos y un titulo significativamente mas bajo que los testigos 48 horas despues de la segunda inoculacion. Esta diferencia desaparecio 5 dias mas tarde. De esta manera demostro que existe una respuesta inmunologica menor debida al acido ribonucleico. Ademas se observo que esta accion es transitoria, recuperandose la respuesta secundaria 7 dias despues de la segunda inoculacion. Esa accion probablemente se debe a bloqueo de los macrofagos
Assuntos
Antígenos de Histocompatibilidade Classe II , Imunidade , RNA , Salmonella typhimuriumRESUMO
Se trataron intraperitonealmente ratas hembras con RNA obtenido de bazo de rata normal de la misma linea, las que se inocularon 5 dias mas tarde con Salmonella typhimurium. En la respuesta primaria se observo una demora significativa en la aparicion de los anticuerpos y un titulo significativamente mas bajo que los testigos 48 horas despues de la segunda inoculacion. Esta diferencia desaparecio 5 dias mas tarde. De esta manera demostro que existe una respuesta inmunologica menor debida al acido ribonucleico. Ademas se observo que esta accion es transitoria, recuperandose la respuesta secundaria 7 dias despues de la segunda inoculacion. Esa accion probablemente se debe a bloqueo de los macrofagos
