RESUMO
The Nail Patella Syndrome (NPS) is an autosomal dominant connective tissue disorder affecting the nails, skeletal system, kidneys and eyes. Here, we report a case of NPS detected at 19 weeks of gestation. The movements of the elbow and knee joints were restricted and there was rotational deformity of the knee joints. To our knowledge, this is the first report of in-utero restriction of limb movements in a fetus with NPS.
RESUMO
Factor XIII deficiency is a rare cause of early abortion. The obstetrical outcome of four pregnancies in two women with factor XIII deficiency is reported. Both women were treated with substitution therapy using locally-prepared cryoprecipitate. The outcome in these two women demonstrated the need for substitution therapy in early pregnancy leading to an increased chance of obstetrical success.
Assuntos
Aborto Espontâneo/etiologia , Aprotinina/uso terapêutico , Deficiência do Fator XIII/diagnóstico , Complicações Hematológicas na Gravidez/diagnóstico , Resultado da Gravidez , Aborto Espontâneo/prevenção & controle , Adulto , Deficiência do Fator XIII/complicações , Feminino , Seguimentos , Idade Gestacional , Humanos , Gravidez , Recidiva , Medição de RiscoRESUMO
Hyperthyroidism can occur secondary to gestational trophoblastic disease. The clinical and biochemical data of four women who had hyperthyroidism secondary to gestational trophoblastic disease was analyzed. The parity ranged from primi to gravida four and the period of amenorrhoea from six weeks to sixteen weeks. Three women had vomiting, two had bleeding per vaginum and two had tachycardia and minimal thyromegaly. The betahCG was more than 5,00,000 mlu/ml in all the cases. Three women required treatment for the hypermetabolic status and one woman had biochemical hyperthyroidism. Two of them had molar pregnancy, one had partial mole and one had persistent trophoblastic disease.
Assuntos
Hipertireoidismo/etiologia , Complicações Neoplásicas na Gravidez , Neoplasias Trofoblásticas/complicações , Neoplasias Uterinas/complicações , Adulto , Feminino , Humanos , Hipertireoidismo/diagnóstico , GravidezAssuntos
Glicerol , Hemólise/efeitos dos fármacos , Vitamina A/farmacologia , Animais , Cobaias , Técnicas In Vitro , Talassemia/sangueRESUMO
The activity of beta-glucuronidase was studied in the gastric aspirate from normal individuals, cases of duodenal ulcer with pyloric stenosis and carcinoma of the stomach. The optimum pH for the activity of this enzyme in the gastric aspirate is 4.0 to 5.5. Cimetidine, a H2-receptor antagonist, was administered orally to obtain the optimum pH for the enzyme activity, when the pH of the gastric aspirate was less than 4.0. It is observed that the enzyme activity in cases of carcinoma of the stomach is markedly elevated (p less than 0.01), when compared with other cases in this study. It is suggested that the elevated enzyme activity in the gastric aspirate could be used as a biochemical marker in the diagnosis of carcinoma of the stomach.
