Plasmocitoma extramedular de nódulos linfáticos en un perro / Lymph nodes extramedullary plasmacytoma in a dog

El plasmocitoma extramedular es una masa tumoral constituida por células plasmáticas distantes de la médula ósea, clasificándose como tumor cutáneo y no es de presentación frecuente en perros. Se atendió en la en el centro veterinario ZOOGAR un paciente canino macho, mestizo, de ocho años de edad con evidente linfadenopatía generalizada al examen clínico. Al examen histológico post mortem, reveló células plasmáticas en nódulos linfáticos, encontrándose focos de necrosis, coagulación y hemorragia tanto en la parte cortical como la medular; con remodelación tisular por tejido conectivo. El hígado y bazo presentaron evidencia de metástasis, específicamente el hígado, a nivel de las triadas portales y áreas centrolobulillares. Los plasmocitomas extramedulares de nódulos linfáticos son raros en perros y no ha sido reportado en estos órganos.

Extramedullary plasmacytoma is a tumor mass composed of plasma cells distant from the bone marrow, classified as skin tumor and is not often present in dogs. The veterinary center ZOOGAR received a canine patient, male, mixed breed; age eight with generalized lymphadenopathy evident after clinical examination. Postmortem histological examination revealed plasmatic cells in lymph nodes, finding sources of necrosis, coagulation and hemorrhage in both the cortical and medullary part; with tissue remodeling by connective tissue. The liver and spleen showed evidence of metastasis, specifically the liver, at the level of portal triads and centrilobular areas. The lymph node extramedullary plasmacytomas are rare in dogs and have not yet been reported in these organs.

[The integrated management software of primary care,a tool for analysing indicators of use]. / El software de gestión integral de la atención primaria, una herramienta de análisis de los indicadores de utilización.

OBJECTIVES: To analyse the indicators of use in the Gran Canaria Health Area. To characterise over-users so that the primary care team can take corrective measures. To design a computer tool giving appropriate useful information to the management, that can be directly put into practice in primary care. DESIGN: Retrospective descriptive study. SATTING: Gran Canaria Health Area. Hierarchical descent in the analysis of data in the base health area and family care unit, in the year 2000. PARTICIPANTS: Users of the Canaries Health Service registered on the individual health card data base. MAIN MEASUREMENTS AND RESULTS: The activity generated by 636 270 users with 2 876 394 appointments was studied. Mean frequency of attendance in the Gran Canaria Health Area was 4.52, with a 67.3% use rate. The user causing 11 or more visits per year was defined as an over-user. 13.4% of users were over-users and caused among them 52.3% of visits. 32.7% of users registered made no visit. CONCLUSIONS: A small section of the population causes over half the consultations. The characteristics of these users need to be analysed so that programmes can be worked out to decrease their frequency of use. The integrated management software for primary care enables this information to be analysed and serves as a support for the primary care teams. Special attention needs to be paid to the population that does not use the health centres.

El software de gestión integral de la atención primaria, una herramienta de análisis de los indicadores de utilización / The comprehensive management software primary care, an analysis tool utilization indicators

Objetivo. Analizar los indicadores de utilización del Área de Salud de Gran Canaria. Caracterizar al grupo hiperfrecuentador con el fin de emprender medidas correctoras desde el equipo de atención primaria. Diseñar una herramienta informática que aporte información adecuada y útil a la gestión y que sea de aplicación directa en los equipos de atención primaria. Diseño. Estudio descriptivo, retrospectivo. Emplazamiento. Área de Salud de Gran Canaria. Descenso jerárquico en el análisis de los datos a zona básica de salud y unidad de atención familiar. Año 2000.Participantes. Usuarios del Servicio Canario de la Salud registrados en la base de datos de la tarjeta sanitaria individual. Mediciones y resultados principales. Se estudió la actividad creada por 636.270 usuarios que generaron 2.876.394 citas. La frecuentación media del Área de Salud de Gran Canaria fue de 4,52, con una tasa de utilización del 67,3 por ciento. Se definió como hiperfrecuentador al usuario que genera 11 o más citas en un año. El 13,4 por ciento de los usuarios fue hiperfrecuentador, y generó el 52,3 por ciento de las visitas. Un 32,7 por ciento de los usuarios no generó ninguna visita. Conclusiones. Una pequeña parte de la población genera más de la mitad de la consulta. Se hace preciso analizar las características de estos usuarios con el fin de elaborar programas destinados a disminuir su frecuentación. El software de gestión integral de la atención primaria permite analizar esta información, y sirve como apoyo a los equipos de atención primaria. Es necesario prestar atención especial a la población no frecuentadora. (AU)

Determination of organophosphorus pesticides in honeybees after solid-phase microextraction.

A method based on solid-phase microextraction (SPME) followed by gas chromatography with nitrogen-phosphorus detection was developed for the purpose of determining 18 organophosphorus pesticide residues in honeybee samples (Apis mellifera). The extraction capacities of polyacrylate and poly(dimethylsiloxane) fibers were compared. The main factors affecting the SPME process, such as the absorption time profile, salt, and temperature, were optimized. The method involved honeybee sample homogenization, elution with an acetone:water solution (1:1) and dilution in water prior to fiber extraction. Moreover, the matrix effect on the extraction was evaluated. In samples spiked at the 0.2 mg kg(-1) level, the coefficient variation was between 1 and 13% and the detection limits were below 10 microg kg(-1). The SPME procedure was found to be quicker and more cost-effective than the solvent extraction method commonly used. The method was applied successfully to environmental screening. Parathion methyl was detected and confirmed in the real samples analyzed.

Microphthalmos, facial capillary hemangioma and Dandy-Walker malformation.

We present a 6-month-old girl with the unusual combination of microphthalmos, facial capillary hemangioma and Dandy-Walker malformation. This is the fourth case with such an association reported in the literature. On the basis of the experience with our patient and with those previously reported, we stress the importance of performing brain-imaging studies on all infants with large facial hemangiomas, or if unusual ophthalmic findings are present.

Chemical Constituents of the Lichen Ramalina hierrensis.

The following compounds have been isolated from the lichen RAMALINA HIERRENSIS, collected on savin, and endemic to the Canary Islands: ursolic acid, iso-arborinol acetate, beta-sitosterol, ergosterol peroxide, cerevisterol, (-)-sandaracopimaric acid, parietin, (+)-usnic acid, (+)-iso-usnic acid, divaricatic acid, atranorin, stictic acid, gangaleodin, variolaric acid, montagnetol, and hierridin. The structures of all compounds were elucidated by physical, spectral, and chemical methods.

[Acute pancreatitis: etiopathogenesis, physiopathology and clinical aspects]. / Pancreatitis aguda: etiopatogenia, fisiopatología y clínica.

Acute pancreatitis is a serious clinical problem. Many of the etiopathogenic mechanisms are not clear and its pathophysiology is very complex, with multisystemic implications. The outcome may be severe, and there is no general agreement on the therapeutic approach. In the present paper we review the newest etiopathogenic and physiopathologic concepts on acute pancreatitis as well as the diagnostic criteria on this condition.