[Hematologic and cytochemical effects in specialists working with radiolocalization and radio navigation means]. / Gematologicheskie i tsitokhimicheskie éffekty u spetsialistov, osushchestvliaiushchikh ékspluatatsiiu sredstv radiolokatsii i radionavigatsii.

Examination of workers servicing radio location, radio navigation and communication means proved electromagnetic radiofrequency waves to induce some peripheral blood changes: cytopenia, Hb decrease, lower RBC and WBC counts, increased RBC with basophilic granularity, WBC metabolism alteration (higher acid phosphatase and myeloperoxidase activity), disordered lymphocytes subunits (T-helpers, T-suppressors) ratio and T- and B-cells numbers.

[The study of the structure of active center of membrane-bound cytochrome p-450 using 1-naphthoxyalcanthiols]. / Izuchenie stroeniia aktivnogo tsentra membranosviazannogo tsitokhroma P450 s pomoshch'iu 1-naftoksialkantiolov.

Homologous 1-naphtoxyalcanthiols of the type 1-C10H7O(CH2)nSH (n = 2-7) are used for structural studies of the microsomal cytochrome P450 active centre. It was found that the strongest complex of thiol with P450 is formed for n = 3. Microsomal oxidation of P450 substrates aminopyrine and benz(a) pyrene is inhibited by the 1-naphtoxyalcanthiols studied. A non-monotonous dependence of pI50 on n was found, the compound with a chain length n = 3 appeared to be the most effective inhibitor. The interaction of this thiol (n = 3) with both the heme group of P450 and the hydrophobic substrate zone is supposed and the distance between these points was estimated. It is possible to employ this approach for structural studies on the active centers of different isoforms of P450.