[Oral health status in children with intellectual disability living in organized groups].

The aim of the study was to assess oral health status in in children with intellectual disability (ID) living in Moscow Orphanage №15. The study involved 91 children aged 12 (39 children) and 15 (52 children). Caries incidence and DMFT index, periodontal disease incidence, OHI-S and PMA index, malocclusions incidence were assessed at baseline examination. Caries incidence in 12 and 15 y.o. was moderate (53.85% and 56.0%, correspondingly), as well as DMFT (2.77±0.52 и 2.94±0.53 correspondingly). In 2 children with rumination syndrome all teeth were affected by caries and these children received dental treatment under general anesthesia 7 times during last 60 months. Periodontal disease incidence in 12 and 15 y.o. was 89.74% и 86.58%, correspondingly with very high OHI-S indicating unsatisfactory oral hygiene. Malocclusions incidence was 95% and 98%, correspondingly. Thus the main oral problem in children with ID is periodontal disease and poor oral hygiene. Differentiated oral hygiene education approach according to children's physical and intellectual abilities should be considered. Children with rumination syndrome should be addressed by neurologist prior to dental treatment which needs more radical approach.

Changes in lipid metabolism during Walker 256 tumor growth and the therapeutic effect of hyperthermia.

The dynamics of lipoprotein content during Walker 256 tumor growth in rats was studied. Moderate changes in HDL and LDL were paralleled by significant changes in VLDL level. A 2-fold increase of VLDL in comparison with the intact control was recorded on day 10 of tumor growth. Exposure to total hyperthermia additionally stimulated VLDL synthesis and this parameter increased by 4 times and more in rats with tumors in comparison with controls. This effect of hyperthermia correlated with significant subsequent decrease of rat mortality caused by the lethal effect of the tumor.