Design and Analysis of an SPR Sensor Based on Antimonene and Platinum for the Detection of Formalin.

Detection of formalin to prevent food adulteration, especially in tropical countries, is of primary concern for public health issues. Life-threatening diseases such as leukaemia and lymphoma occur due to the regular consumption of formalin with food. Traditionally, spectrophotometry and chromatography-based sensors have been employed to detect formalin, which have limitations related to their ability to achieve high sensitivity, selectivity, and fast response. In this paper, a surface plasmon resonance (SPR) sensor for improved sensing of formalin is proposed. The Kretschmann configured SPR sensor probe is designed using silver (Ag), platinum (Pt), antimonene, and chitosan, which increases the sensitivity and selectivity. The maximum sensitivity achieved for the proposed SPR sensor is 206.86 °/RIU. The distribution of the electric field (Ey) component of the electric field is also evaluated to analyze the field enhancement at different layer interfaces and to calculate the penetration depth (176.75 nm).

A nanolayered structure for sensitive detection of hemoglobin concentration using surface plasmon resonance.

The objective of the proposed work is to design a biosensor that monitors hemoglobin (Hb) concentration using the combination of nanolayer, i.e., barium titanate (BaTiO3) and antimonene based on surface plasmon resonance (SPR) technique. Antimonene is used here as bio-recognition element (BRE) layer to attach the Hb analyte through physical adsorption due to its hydrophilic nature, higher adsorption energy and larger active surface area. The use of BaTiO3 adlayer (7 nm) just before antimonene is to enhance the refractive index (RI) sensitivity up to 1.90 times for the proposed SPR biosensor. The reason behind sensitivity enhancement is its high dielectric constant which enhances the electromagnetic field with in analyte medium. The performance of the biosensor is demonstrated with performance parameters namely sensitivity, detection accuracy (DA), figure of merit (FOM) and resolution. The proposed biosensor has potential to achieve much higher performance in terms of RI sensitivity of 303.83°/RIU, FOM of 50.39 RIU-1 and resolution of 0.021 g/l in comparison with reported biosensors in the literature for detection of Hb concentration. Thus, based on the obtained results one can say that the proposed work unlocks a reliable sensing in the field of medical science to detect hemoglobin-related diseases in human being.