[Factors associated with antiretroviral treatment and their influence on health related quality of life in HIV infected patients]. / Factores relacionados con el tratamiento antirretroviral y su influencia en la calidad de vida relacionada con la salud en personas infectadas por VIH.

OBJECTIVES: Access to antiretroviral treatment (ART) has become essential to delay HIV clinical progression and increase survival, so improving Health Related Quality of Life (HRQL). The aim of this investigation was to describe factors associated with ART and their impact on HRQL in HIV infected patients. METHODS: A cross-sectional study on 150 HIV-outpatients in a tertiary hospital was designed, and ART-related data collected. Adherence was assessed by the SMAQ questionnaire. HRQL data were collected by disease-specific questionnaire MOS-HIV (Medical Outcomes Study HIV Health Survey). RESULTS: A total of 84% of patients were on ART. Half of the treatment regimens were Protease inhibitor (PI) based, LPV/r being the most commonly used drug. The large majority of treatments used (89.7%) were second line or successive, and NNRTI-based combinations were the most used in first line. Lipodystrophy was the most frequently referred side-effect (61.1%). Almost all (94.5%) of our patients declared they were adapting well to treatment in their daily-life-activities, with 64.3% adhering to treatment according to the SMAQ (Simplified Medication Adherence Questionnaire) questionnaire. In the HRQL, patients with PI-based treatment got lower scores in 4 of 11 domains with the MOS-HIV questionnaire; while patients that adapted well to their ART had better scores in 4 of 11 domains and overall HRQL assessment in MOS-HIV. CONCLUSIONS: Most of our patients were on ART during our investigation. We have documented a negative association between PI-based treatment and HRQL domains, and a positive association between subjective ART adaptation and HRQL. The assessment of HRQL in this population has increasing interest as it is influenced by ART related factors as treatment improves life conditions of HIV infected people.

Factores relacionados con el tratamiento antirretroviral y su influencia en la calidad de vida relacionada con la salud en personas infectadas por VIH / Factors associated with antiretroviral treatment and their influence on health related quality of life in HIV infected patients

Objetivo El acceso al tratamiento antirretroviral (TARV) retrasa la progresión clínica del VIH y aumenta la supervivencia, mejorando la calidad de vida relacionada con la salud (CVRS). El objetivo de nuestra investigación fue describir los factores asociados al TARV y su influencia en la CVRS en personas infectadas por VIH. Material y método Se diseñó un estudio transversal en 150 pacientes con VIH de un hospital de tercer nivel, recogiéndose datos relativos al TARV. La adherencia se valoró con el cuestionario SMAQ (Simplified Medication Adherence Questionnaire). Los datos de CVRS se obtuvieron con el cuestionario MOS-HIV (Medical Outcomes Study HIV Health Survey).Resultados El 84% de nuestros pacientes estaban en TARV. La mitad de las pautas se basaban en inhibidores de la proteasa (IP), siendo LPV/r el fármaco de este grupo más empleado. En el 89,7% el régimen era el segundo o sucesivo, y la combinación basada en no análogos la más empleada en el tratamiento de primera línea. La lipodistrofia fue el efecto secundario más referido (61,1%). El 94,5% adaptaba bien el TARV a su vida diaria, siendo adherentes el 64,3%, según el cuestionario SMAQ. En cuanto a la CVRS, los pacientes con IP obtuvieron peores puntuaciones en 4 de las 11 dimensiones del cuestionario MOS-HIV. Los pacientes que dijeron adaptar bien el TARV presentaron mejores puntuaciones en 4 de las 11 dimensiones y en la valoración global del MOS-HIV. Conclusiones La prevalencia de pacientes en TARV en nuestra serie fue alta, habiéndose documentado relación negativa entre la toma de IP y CVRS, y positiva entre adaptación subjetiva del TARV y CVRS. La valoración de la CVRS en estos pacientes es importante, ya que se ve influida por factores relativos al TARV, dado que este mejora las condiciones vitales de las personas infectadas por VIH (AU)

Objectives Access to antiretroviral treatment (ART) has become essential to delay HIV clinical progression and increase survival, so improving Health Related Quality of Life (HRQL). The aim of this investigation was to describe factors associated with ART and their impact on HRQL in HIV infected patients. Methods A cross-sectional study on 150 HIV-outpatients in a tertiary hospital was designed, and ART-related data collected. Adherence was assessed by the SMAQ questionnaire. HRQL data were collected by disease-specific questionnaire MOS-HIV (Medical Outcomes Study HIV Health Survey).Results A total of 84% of patients were on ART. Half of the treatment regimens were Protease inhibitor (PI) based, LPV/r being the most commonly used drug. The large majority of treatments used (89.7%) were second line or successive, and NNRTI-based combinations were the most used in first line. Lipodystrophy was the most frequently referred side-effect (61.1%). Almost all (94.5%) of our patients declared they were adapting well to treatment in their daily-life-activities, with 64.3% adhering to treatment according to the SMAQ (Simplified Medication Adherence Questionnaire) questionnaire. In the HRQL, patients with PI-based treatment got lower scores in 4 of 11 domains with the MOS-HIV questionnaire; while patients that adapted well to their ART had better scores in 4 of 11 domains and overall HRQL assessment in MOS-HIV. Conclusions Most of our patients were on ART during our investigation. We have documented a negative association between PI-based treatment and HRQL domains, and a positive association between subjective ART adaptation and HRQL. The assessment of HRQL in this population has increasing interest as it is influenced by ART related factors as treatment improves life conditions of HIV infected people (AU)