RESUMO
No disponible
Assuntos
Feminino , Adulto , Humanos , Intussuscepção/diagnóstico , Melanoma/complicações , Neoplasias do Íleo/patologia , Neoplasias do Jejuno/patologia , Intussuscepção/patologia , Metástase Neoplásica/patologiaRESUMO
No disponible
Assuntos
Pessoa de Meia-Idade , Masculino , Humanos , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Colo , Divertículo do ColoRESUMO
A Colombian strain of Trypanosoma rangeli was characterized by analyzing its behaviour in different axenic and cellular culture, its infection rate and the histopathological lesions produced in experimental animals. Although slight inflammatory infiltrations were shown in different histopathological sections, no pseudocysts could be observed. Grace's insect medium is better than liver infusion tryptose or artificial triatomine urine supplemented with proline when studying T. rangeli metacyclogenesis, with a peak of 32 per cent trypomastigotes. High infection rates were found in VERO and J774 cells. Because of its 100 per cent infectivity rates and adequacy of parasitemia levels, C23 strain is a suitable model of T. rangeli biology study.
Assuntos
Animais , Infecções/parasitologia , Trypanosoma/isolamento & purificação , Técnicas de Cultura de CélulasRESUMO
A Colombian strain of Trypanosoma rangeli was characterized by analyzing its behaviour in different axenic and cellular culture, its infection rate and the histopathological lesions produced in experimental animals. Although slight inflammatory infiltrations were shown in different histopathological sections, no pseudocysts could be observed. Grace's insect medium is better than liver infusion tryptose or artificial triatomine urine supplemented with proline when studying T. rangeli metacyclogenesis, with a peak of 32% trypomastigotes. High infection rates were found in VERO and J774 cells. Because of its 100% infectivity rates and adequacy of parasitemia levels, C23 strain is a suitable model of T. rangeli biology study.
Assuntos
Trypanosoma/isolamento & purificação , Animais , Colômbia , Camundongos/parasitologiaRESUMO
We investigated the protective effect of Trypanosoma rangeli against infection with Trypanosoma cruzi in animal models of various ages and with different doses of inoculum. The age of the mice and the dose of parasites determined the course of the infection. When T. cruzi was inoculated into mice after challenge with T. rangeli, parasitaemia was more controlled, mortality decreased and histopathology showed lower inflammatory infiltration and pseudocysts. This study proposes a new murine model of the protective effect of recombinant proteins of T. rangeli for possible application in the vaccines field.
