1.
Bioorg Med Chem Lett
; 26(2): 272-276, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26707395
RESUMO
A novel series of substituted quinazoline derivatives were designed, synthesized and evaluated for their hypolipidemic activity in cholesterol induced hyperlipidemic rats. In vivo screening concluded that compounds A-4, C-5 and C-6 have shown potent antihyperlipidemic activity by decreasing the plasma level of triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL), followed by increase in level of high density lipoprotein (HDL).