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Toxicol In Vitro ; 43: 58-61, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28599844

RESUMO

Vaccines against human papilloma virus (HPV) have been demonstrated to be very effective to prevent infection-related neoplasms. However, several reports describing heterogeneous post-vaccination phenomena have been published in last few years. The spectrum of these disorders includes both immune-mediated neurological diseases and neuropsychiatric functional disorders. Some researchers speculated about a genetic predisposition, but others hypothesized a role of adjuvants, including some metals and, particularly, aluminum. Here, we tested sixteen young girls developing somatoform and neurocognitive syndromes after the HPV immunization, through MELISA® test, detecting cell-mediated hypersensitivity to several metals. We found no association between these neurocognitive disorders and the results provided by this test; importantly, no patients showed hypersensitivity to aluminum, which is the inorganic adjuvant included in HPV vaccines. Thus, if aluminum played a role in the pathophysiology of musculoskeletal and neurocognitive disturbances occurring in some young girls after HPV immunization, that should recognize other mechanisms than the activation of aluminum-specific lymphocytes.


Assuntos
Adjuvantes Imunológicos/administração & dosagem , Hidróxido de Alumínio/administração & dosagem , Hipersensibilidade/etiologia , Vacinas contra Papillomavirus/efeitos adversos , Fosfatos/administração & dosagem , Adolescente , Adulto , Criança , Feminino , Humanos , Hipersensibilidade/sangue , Hipersensibilidade/imunologia , Linfócitos/imunologia , Metais/administração & dosagem , Metais/efeitos adversos , Transtornos Neurocognitivos/sangue , Transtornos Neurocognitivos/etiologia , Transtornos Neurocognitivos/imunologia , Vacinas contra Papillomavirus/administração & dosagem , Transtornos Somatoformes/sangue , Transtornos Somatoformes/etiologia , Transtornos Somatoformes/imunologia , Adulto Jovem
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