[The effect of a low-intensity helium-neon laser on succinate dehydrogenase activity in unmineralized periodontal and dental tissues]. / Vliianie nizkointensivnogo gelii-neonovogo lazera na aktivnost' suktsinatdegidrogenazy v nemineralizovannykh tkaniakh parodonta i zubov.

Laser effects with energy density of 28.8, 86.4, 144 J/cm2 and 86.4 J/cm2 in combination with fluorine agents on succinate dehydrogenase (SDH) activity were studied in 264 noninbred white rats (5 groups). The animals were decapitated in 1, 6, 12, 24, 48, 72 h and 12 and 30 days. The findings evidence elevated SDH activity virtually in all periods tested. Laser exposure enhanced enzymic activity in all the animals.

[Proof of stimulating effect of dalargin of the process of cell division through opiate receptors]. / Dokazatel'stva realizatsii stimuliruiushchego éffekta dalargina na protsess kletochnogo deleniia cherez opiatnye retseptory.

The role of opiate receptors on cell division in corneal epithelium during administration of dalargin was analysed. Naloxone injection/200 micrograms/kg/decreased MI two times, DNA-synthesis 1.4 times over 24 hours. Naloxone prevented dalargin effect on cell proliferation. Another testimonies of dalargin opiate-binding mitogenic effect were the results of the study with dalargin analogues. They are agonists of opiate receptors too. These drugs, as well as dalargin, in a dose 10 micrograms/kg increased DNA-synthesis 1.5 times, MI and MIK 2.2 times. It turned out, that the administration of another two analogues of dalargin, which are not ligands of opiate receptors, probably do not cause an adequate increase of DNA-synthesis and mitotic index.

[Effect of a stable analog of leu-enkephalin, dalargin, on the cell division of the corneal epithelium in white rats]. / Vliianie stabil'nogo analoga lei-enkefalina--dalargina na protsessy kletochnogo deleniia épiteliia rogovitsy belykh krys.

The effect of Leu-enkephalin analog--dalargin--on the corneal epithelium proliferation has been studied in white rats. 10 microliter dalargin per 1 kg body weight were administered intraperitoneally at 8 a.m. The mitotic index (MI), DNA synthesis cell index and label intensity (LI) were determined every 4 hours over a 24-hour period. The results obtained demonstrate that dalargin stimulates DNA synthesis in cells throughout the entire period of action. MI increased only 4, 8, 12 hours after dalargin administration. Mean daily DNA synthesis cell index and MI increased 2.1-fold and 3.1-fold, respectively after dalargin administration. It is suggested that dalargin activates the cell division processes by speeding up mitosis, shortening the premitotic period, accelerating the speed of the DNA synthesis and increasing cell proliferation pool.

[Effect of opioid receptor ligands on cell division processes in the corneal epithelium of the white rat]. / Vliianie ligandov opioidnykh retseptorov na protsessy kletochnogo deleniia épiteliia rogovitsy belykh krys.

The effects of the application of synthetic leu-enkephalin analogue--dalargin and naloxone on DNA synthesis and cell division in corneal epithelium were studied with the drugs injected once or five times. The influence of one and five intraperitoneal injections of the drugs in question at a dose of 10 micrograms/kg body weight was also investigated. In both cases the opioid receptor ligands examined activated DNA synthesis with the following adequate increase in mitotic index.