RESUMO
OBJECTIVE: To establish a quantitative method of non-blood withdrawn with 99mTc-ECD SPECT for measuring cerebral blood flow (CBF). METHOD: Combining three compartment models and technology of the best parameters by computer with 99mTc-ECD SPECT to quantitate CBF and regional cerebral blood flow (rCBF) in control group and patient group. RESULTS: The CBFs of the control group (8 cases) and the patient group (16 cases) were (57.16 +/- 4.21) ml.min-1/100 g and (38.80 +/- 8.21) ml.min-1/100 g, respectively. The CBF and rCBF were significantly lower in patient group than those in control group (P < 0.05). CONCLUSION: The method is simple and more convenient for quantification of CBF in patients with brain disorders, and it may increase the diagnostic sensitivity and the accuracy of focus location. It is suggested that the method is accurate and reliable.
Assuntos
Circulação Cerebrovascular/fisiologia , Cisteína/análogos & derivados , Ataque Isquêmico Transitório/fisiopatologia , Compostos de Organotecnécio , Insuficiência Vertebrobasilar/fisiopatologia , Adolescente , Adulto , Idoso , Velocidade do Fluxo Sanguíneo , Feminino , Humanos , Ataque Isquêmico Transitório/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada de Emissão de Fóton Único , Insuficiência Vertebrobasilar/diagnóstico por imagemRESUMO
Short whole circumference and semi-circumference intussusception valves were created in interposition cholecysto-jejunal-duodenal conduits in pigs to determine which method best prevented gastrointestinal reflux into the biliary tract. Following intravenous injection of 99 mTc-HIDA the time interval for its excretion from the liver and appearance in the duodenum was not different in either whole or semi-circumference valve animals or in controls without valves. After intragastric administration of 99 mTc-DTPA the relative radioactivity of gallbladder contents (reflux) in the cohort without valves was significantly higher than in both cohorts with valves. Animals with semi-circumferential valves in turn had significantly higher levels of nuclide than those with whole circumference valves. Reflux was observed grossly in 100% of animals without valves, in 20% of those with semi-circumference valves, and in no animals with whole circumference valves. This study indicates that both whole and semi-circumference intussusception valves placed in jejunal biliary conduits allow unimpeded flow of bile into the gastrointestinal tract. Whole circumference valves are more effective for prevention of reflux than semi-circumferential valves.
