[Clinical and hemodynamic efficiency of dilatrend treatment in patients with dilatation cardiomyopathy].

In present study we describe the clinical case of successful treatment of dilatation cardiomyophaty based on dilatrend using. 32 years old patient with acute heart failure and rhythm dysfunction was active user of alcohol since 1993. At the beginning of treatment 25 mg of dilatrend twice per day was used. The dose was increased monthly by 2.5 mg. After 4 months of treatment clinical signs of disease were eliminated at the daily dose 50 mg of dilatrend. In order to recover from arrhythmia on the seventh month of treatment cardioversion was successfully carried out. As it follows from our experience dilatrend is very effective for treatment of dilatative cardiomyopathy of alcoholic genesis.

[Energy exchange in mitochondria and contractility of bundles of glycerinated myocardial fibers in traumatic shock]. / Energeticheskii obmen mitokhondrii i sokratimost' puchkov glitserinizirovannykh volokon miokapda pri travmaticheskom shoke.

The state of energy exchange on the basis of respiratory chain reactions of myocardial mitochondria and contractility of bundles of glycerinated muscle fibers in traumatic shock, were investigated. The mitochondria isolated from animal myocardium at the terminal stage of traumatic shock were found to be capable to carry out oxidative phosphorylation at the level typical for healthy animal mitochondria. Parallel tensometric analyses of contractility of bundles of glycerinated muscle fibers showed that in rats and dogs with traumatic shock the most pronounced changes occur in isometric tension and specific power. At the same time relative fiber shortening under isotonic conditions is insignificantly reduced.