Tribological Behavior of NiMoAl-Based Self-Lubricating Composites.

The present study focused on the development of NiMoAl-based self-lubricating composites using solid lubricants as the second phase by powder metallurgy. For this, Cr2AlC MAX phase, Cr2AlC-Ag, and MoS2 powders were mixed with the NiMoAl-based matrix and subsequently hot pressed to produce bulk composite samples. The average hardness and wear resistance of the matrix were found to be increased with the addition of MoS2, Cr2AlC MAX phase, and Cr2AlC-Ag powder to the NiMoAl matrix. The addition of Cr2AlC to NiMoAl was more effective in improving the wear resistance than MoS2. The addition of Cr2AlC and Cr2AlC-Ag has increased the hardness by about 75% than that with the addition of NiMoAl alloy. A scanning Kelvin probe system was used to study the surface properties of the tribofilm in detail through work function mapping from the edge area to the wear area (groove). Among all the samples, the one with the addition of Cr2AlC-Ag powder to the NiMoAl matrix possesses the best tribo-mechanical properties. Cr2AlC-Ag composite addition to NiMoAl was found to decrease the wear rate by one-third and to reduce the coefficient of friction by one-fourth, compared to the base NiMoAl alloy. This was attributed to the high-sintered density and formation of strong tribofilms consisting of mixed oxides such as Ag2MoO4 and Al2O3, as confirmed by micro Raman spectra.

A Novel Mutation in Helical Domain 2 of NOD2 in Sporadic Blau Syndrome.

We report a 12-year-old girl who presented with bilateral granulomatous anterior uveitis accompanied by boggy arthritis of knee and ankle joints, intermittent fever, and nodular skin rash. She was diagnosed with sporadic Blau syndrome (early-onset sarcoidosis) based on above clinical signs and presence of non-necrotising granuloma on iris biopsy. DNA sequencing revealed a previously unreported heterozygous mutation consisting of a G>A transition in exon 4 of the NOD2 gene. This resulted in a glutamic acid to lysine substitution in helical domain 2 of the nucleotide binding and oligomerization (NACHT) region, possibly reducing efficiency of auto-inhibition in NOD2 signaling. Interestingly, the ocular inflammation resolved completely following therapeutic vitrectomy in both eyes whereas the systemic symptoms of fever and arthritis continued to wax and wane while on treatment with oral methotrexate and corticosteroids.