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3.
Diagn Cytopathol ; 33(3): 187-90, 2005 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16078253

RESUMO

Sinus histiocytosis with massive lymphadenopathy (SHML or Rosai-Dorfman disease) is a nonneoplastic, usually self-limiting disease. Alhough it affects all age groups, it is more commonly seen in young males in their first or second decades. The disease primarily manifests as painless lymphadenopathy of cervical region, but other nodal groups and extranodal sites may also be affected. Seldom SHML may involve the salivary glands. We present the cytologic features and differential diagnoses of one such case.A 45-yr-old woman presented with an enlarged submandibular gland on the left side with ipsilateral cervical lymphadenopathy that had been persisting for 1 mo. The gland and the two enlarged nodes measured 2.5 x 2.5 cm(2) each and were firm in consistency. Clinically, tumor of the salivary glands was suspected. Fine-needle aspiration (FNA) smears showed moderate cellularity, with large histiocytes dispersed in the background of intense lymphoplasmacytic infiltrate. These histiocytes showed lymphophagocytosis. Isolated stromal fragments consisting of fibrocytes were seen separate from salivary acinar clusters on repeat aspirations. The diagnosis of SHML involving left submandibular gland and ipsilateral lymph nodes was returned. When analyzed in the context of clinical findings (laboratory data), the cytologic features of SHML involving salivary gland could be differentiated from those of malignancies and other benign lesions, especially Kuttner's tumor of the submandibular gland, which mimics neoplasm clinically.


Assuntos
Histiocitose Sinusal/patologia , Doenças das Glândulas Salivares/etiologia , Doenças das Glândulas Salivares/patologia , Biópsia por Agulha Fina , Diagnóstico Diferencial , Feminino , Histiocitose Sinusal/complicações , Humanos , Pessoa de Meia-Idade
4.
Acta Cytol ; 49(6): 650-2, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16450906

RESUMO

BACKGROUND: Double pathology is uncommon. The diagnostic effort must be directed toward uncovering a disorder that can explain all the findings in a given patient. However, exceptions occur, notably in the sphere of infectious disorders. This is particularly true in the context of multiple infections in immunocompromised patients. CASE: Fine needle aspiration was performed on 2 lymph nodes in a 22-year-old male. Extramedullary hematopoiesis was seen in 1, while the other showed acellular necrosis with acid-fast bacilli. The hematologic workup revealed chronic myelogenous leukemia. CONCLUSION: Extramedullary hematopoiesis can be a cytologic clue to hematologic disorders. A search for an additional infectious disease may be in order.


Assuntos
Leucemia Mielogênica Crônica BCR-ABL Positiva/complicações , Tuberculose dos Linfonodos/complicações , Adulto , Biópsia por Agulha Fina/métodos , Humanos , Leucemia Mielogênica Crônica BCR-ABL Positiva/diagnóstico , Masculino , Sensibilidade e Especificidade , Tuberculose dos Linfonodos/diagnóstico
5.
Diagn Cytopathol ; 31(5): 340-1, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15468127

RESUMO

Sclerosing lobular hyperplasia (SLH) is an uncommon benign lesion seen in the juvenile breast. It presents as a palpable, firm, circumscribed nodular lump in the breast of a young woman. Histologically, it is characterised by prominent lobular hyperplasia and sclerosis of the intralobular connective tissue. We discuss the cytomorphology and differential diagnosis. A 16-yr-old female patient presented with a painless, firm, nodular, mobile mass in the right breast measuring 4 x 4 cm. The clinical and radiological diagnosis was fibroadenoma. Fine-needle aspiration smears showed round to oval ductal epithelial cells in flat sheets and round clusters with an acinar arrangement. A few bare nuclei were seen dispersed in a clean background but no stroma was visualised. A combination of clinical findings, imaging, and cytological features of SLH can help to differentiate this condition from other palpable juvenile breast diseases.


Assuntos
Biópsia por Agulha Fina/métodos , Doenças Mamárias/patologia , Mama/patologia , Adolescente , Mama/cirurgia , Doenças Mamárias/cirurgia , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Feminino , Fibroadenoma/patologia , Humanos , Hiperplasia/patologia , Hiperplasia/cirurgia , Esclerose/patologia , Esclerose/cirurgia , Resultado do Tratamento
6.
Indian J Pathol Microbiol ; 47(3): 391-4, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16295433

RESUMO

Solid and cystic papillary tumor of pancreas (SCPT) are rare tumors. Of the well described cases 95% have occurred in women of reproductive age, suggesting a role of hormonal factors in the pathogenesis of this tumor. Only few studies evaluating estrogen and progesterone receptor status have found it to be positive. Cytohistocorrelation and immunohistochemistry for estrogen (ER) and progesterone (PR) receptors of three such cases are reported here. All three were diagnosed by fine needle aspiration cytology (FNAC) and showed cytoplasmic positivity for ER and PR receptors. May-Grunwald Giemsa, Papanicolaou and hematoxylin and eosin stained slides were evaluated for cytology and histopathology. Unstained methanol fixed slides were used for immunohistochemistry. The cytoplasmic staining of ER and PR receptors cannot be underestimated, as shown by Carbone A et al which represents ERII receptors. This study confirms the presence of ER and PR receptors in these tumors and highlights the already established cytological features.


Assuntos
Cistadenoma Papilar/patologia , Neoplasias Pancreáticas/patologia , Adulto , Biópsia por Agulha , Cistadenoma Papilar/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Pancreáticas/cirurgia
7.
Arch Gynecol Obstet ; 269(3): 221-3, 2004 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-14564457

RESUMO

CASE REPORT: A case of squamous cell carcinoma of cervix co-existent with endometrial tuberculosis presenting as postmenopausal bleeding is being reported for its rarity. The atrophic postmenopausal endometrium is thought to be poorly supportive of tubercle bacilli. Following a radical Wertheim's hysterectomy patient had a hectic postoperative period, which responded to antitubercular treatment. Diagnosis of tuberculosis in this case was made on histopathology postoperatively and confirmed by polymerase chain reaction (PCR) on scrapes from the granulomas obtained by microdissection. CONCLUSION: Tuberculosis complicating malignant disease may occur in regions with a high prevalence of disease; with a resurgence of tuberculosis worldwide this association may not be uncommon. The diagnosis and treatment of tuberculosis in a patient with cancer assumes importance as a high mortality has been seen in patients with co-existent disease.


Assuntos
Carcinoma de Células Escamosas/diagnóstico , Endométrio/patologia , Tuberculose dos Genitais Femininos/diagnóstico , Neoplasias do Colo do Útero/diagnóstico , Antituberculosos/uso terapêutico , Carcinoma de Células Escamosas/complicações , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Mycobacterium tuberculosis/genética , Mycobacterium tuberculosis/isolamento & purificação , Reação em Cadeia da Polimerase , Tuberculose dos Genitais Femininos/complicações , Tuberculose dos Genitais Femininos/tratamento farmacológico , Tuberculose dos Genitais Femininos/patologia , Neoplasias do Colo do Útero/complicações , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/cirurgia , Hemorragia Uterina/etiologia
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