RESUMO
AIM: A tight control of blood glucose is critical. We compare blood glucose level between isoflurane and desflurane in neurosurgical patients for further application. METHODS: One hundred and eight patients scheduled for neurosurgery under general anesthesia were recruited and divided into two groups; fentanyl-isoflurane-nitrous oxide based and fentanyl-desflurane-nitrous oxide based randomly. Vital signs, end tidal gas concentration, amount of narcotics usage and blood glucose level were recorded at induction (T0) and intraoperative hourly thereafter (T1-T8). Independent t-test and ANOVA were used. The statistical significance was considered if p-value < 0.05. RESULTS: There were 107 patients enrolled excluded one from isoflurane group because of the schedule changes. The amounts of fentanyl usage (0.89+/-0.41 mcg/kg/hr, 0.88+/-0.48 mcg/kg/hr), the end tidal inhales' tension (0.71%+/-0.32, 3.13%+/-1.63) were equivalent in isoflurane and desflurane group. The blood glucose levels at various period of time had no statistical difference but there was a significant (p<0.05) increasing from T1 to T8 comparing to T0 in both groups (3.88+/-0.93 mg%/hr and 5.55+/-1.14 mg%/hr). CONCLUSION: Desflurane has demonstrated the indistinguishable blood glucose level and hemodynamic response from isoflurane anesthesia intraoperatively in neurosurgical patients, confirming a comparable pattern of blood glucose concentration intensifying over time spends.
