RESUMO
Colonic inflammation was produced in rats by chemotactic peptides acting on polymorphonuclear leucocytes. Instillation during one hour of formylated tripeptide: formylmethionyl-leucyl-phenylalanine (FMLP) and a tetrapeptide: alanine-glycine-sefine-glutamine (AGSG) into rat colon caused erosions and exulcerations. Neutrophils increased secondary to instillation, predominantly with FMLP, and mucus depletion was marked in the cecum. Chloride ion secretion and mucosal permeability were significatively greater in the colonic lumen with the chemotactic peptides. Histamine and serotonin concentration were greater in the colonic fluid in animals treated with the peptides. These observations could suggest that the presence of chemotactic peptides at the colonic lumen produce changes at the mucosal wall, that would participate in generation and perpetuation of the colonic inflammation.
Assuntos
Colite , Colite/metabolismo , Mediadores da Inflamação/metabolismo , N-Formilmetionina Leucil-Fenilalanina , Animais , Fatores Quimiotáticos de Eosinófilos/farmacologia , Cloretos/metabolismo , Colite/induzido quimicamente , Liberação de Histamina/efeitos dos fármacos , Mucosa Intestinal/metabolismo , Mucosa Intestinal/patologia , Masculino , Mucinas/metabolismo , N-Formilmetionina Leucil-Fenilalanina/farmacologia , Oligopeptídeos/farmacologia , Permeabilidade/efeitos dos fármacos , Ratos , Ratos Wistar , Serotonina/metabolismoRESUMO
Colonic inflammation was produced in rats by chemotactic peptides acting on polymorphonuclear leucocytes. Instillation during one hour of formylated tripeptide: formylmethionyl-leucy-phenylalanine (FMLP) and a tetrapeptide: alanine-glycine-sefine-glutamine (AGSG) into rat colon caused erosions and exulcerations. Neutrophils increased secondary to instillation, predominantly with FMLP, and mucus depletion was marked in the cecum. Chloride ion secretion and mucosal permeability were significatively greater in the colonic lumen with the chemotactic peptides. Histamine and serotonin concentration were greater in the colonic fluid in animals treated with the peptides. These observations could suggest that the presence of chemotactic peptides at the colonic lumen produce changes at the mucosal wall, that would participate in generation and perpetuation of the colonic inflammation.
Assuntos
Ratos , Masculino , Animais , Cloretos/metabolismo , Colite/induzido quimicamente , Mediadores da Inflamação , Mucosa Intestinal/patologia , Mucinas/metabolismo , N-Formilmetionina Leucil-Fenilalanina , Colo/patologia , Liberação de Histamina/efeitos dos fármacos , Mucosa Intestinal/fisiopatologia , Permeabilidade/efeitos dos fármacos , Ratos Wistar , Serotonina/metabolismoRESUMO
Colonic inflammation was produced in rats by chemotactic peptides acting on polymorphonuclear leucocytes. Instillation during one hour of formylated tripeptide: formylmethionyl-leucy-phenylalanine (FMLP) and a tetrapeptide: alanine-glycine-sefine-glutamine (AGSG) into rat colon caused erosions and exulcerations. Neutrophils increased secondary to instillation, predominantly with FMLP, and mucus depletion was marked in the cecum. Chloride ion secretion and mucosal permeability were significatively greater in the colonic lumen with the chemotactic peptides. Histamine and serotonin concentration were greater in the colonic fluid in animals treated with the peptides. These observations could suggest that the presence of chemotactic peptides at the colonic lumen produce changes at the mucosal wall, that would participate in generation and perpetuation of the colonic inflammation. (AU)
