RESUMO
Forty male hamsters were divided into three groups. Group 1 (16 animals) received topical applications with a 0.5% solution of DMBA in liquid paraffin on the right buccal pouch for 16 weeks. Group 2 (16 animals) received DMBA for 16 weeks, plus the retinoid RO-109359 three times during the 17th week in doses of 200 mg/kg. Group 3 (8 animals) remained untreated for 16 weeks and, during the 17th week, received the retinoid as in group 2. After administration of the retinoid, a marked regression in the size of the carcinomas of the right pouch in group 2 animals was observed clinically. Histologically, these tumors consisted mostly of large necrotic areas and showed an excessive keratin loss. Although the hypervitaminosis A symptoms could not be avoided, the findings suggest that high doses have a therapeutic effect on hamster buccal pouch carcinomas.
Assuntos
Carcinoma de Células Escamosas/tratamento farmacológico , Etretinato/uso terapêutico , Mucosa Bucal/efeitos dos fármacos , Neoplasias Bucais/tratamento farmacológico , 9,10-Dimetil-1,2-benzantraceno , Animais , Carcinoma de Células Escamosas/induzido quimicamente , Carcinoma de Células Escamosas/patologia , Bochecha , Cricetinae , Masculino , Mesocricetus , Neoplasias Bucais/induzido quimicamente , Neoplasias Bucais/patologia , Necrose , Indução de RemissãoAssuntos
Candidíase Bucal/epidemiologia , Leucoplasia Oral/epidemiologia , Líquen Plano/epidemiologia , Doenças da Boca/epidemiologia , Candidíase Bucal/patologia , Feminino , Grécia , Humanos , Leucoplasia Oral/patologia , Líquen Plano/patologia , Masculino , Pessoa de Meia-Idade , Doenças da Boca/patologiaAssuntos
Neoplasias de Cabeça e Pescoço , Linfoma não Hodgkin , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Adenoma Pleomorfo/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/patologia , Glândulas Salivares/patologia , Adenoma Pleomorfo/epidemiologia , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Neoplasias Palatinas/epidemiologia , Neoplasias Palatinas/patologia , Neoplasias das Glândulas Salivares/epidemiologiaRESUMO
A rare case of hemangioendotheliosarcoma is presented. Our review of the literature confirms the difficulties we encountered in arriving at a correct clinical and pathologic diagnosis of this tumor, which seldom appears in the oral cavity, tends to be aggressive, and has a serious prognosis.