RESUMO
Studies of the protein composition of leukocytes revealed markers of general pathology: 2 protein parameters (53K/H2A>0.25; 43K/H2A<1.61) differed from normal in 1627 patients with various pathologies. We compared protein parameters of leukocytes with other markers of general pathology. By the sensitivity and spectrum of associated diseases, the detected protein parameters of leukocytes can serve as the gold standard in the diagnostics of general pathology. These protein markers can be used for screening of newborns requiring therapeutic and preventive treatment, employers exposed to occupational hazards, and people inhabiting ecologically unfavorable regions, and for prevention of therapeutic complications in patients.
Assuntos
Biomarcadores , Leucócitos/imunologia , Proteínas Sanguíneas/análise , HumanosAssuntos
Apoptose/genética , Genes p53 , Marcadores Genéticos , Testes Genéticos , Animais , Doença de Bowen/genética , Caenorhabditis elegans/genética , Carcinoma de Células Escamosas/genética , Células Cultivadas , Cromossomos Humanos Par 17/genética , DNA/genética , Expressão Gênica , Genes Supressores de Tumor , Homeostase , Humanos , Imuno-Histoquímica , Leucócitos/citologia , Monitorização Fisiológica , Mutação , Necrose , Neoplasias/genética , Fenótipo , Células Tumorais Cultivadas/metabolismo , Proteína Supressora de Tumor p53/genéticaRESUMO
Comparative analysis of association with psoriasis before and after treatment of 53K/H2A and 43K/H2A leukocyte protein markers and parameters of leukocyte population (18 indexes) including concentration of peripheral blood lymphocyte subpopulations as markers of the immune status revealed advantages of the former method of patient monitoring for the evaluation of treatment efficacy. The method showed 100% sensitivity and correlation with the dynamics of clinical symptoms. A significant correlation of 53K/H2A parameter with blood content of CD3+, CD4+, CD8+, and CD72+ lymphocytes was established.
