1.
Bioorg Med Chem Lett
; 14(7): 1673-7, 2004 Apr 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15026048
RESUMO
Based on molecular modeling studies, macrocyclic inhibitors of phosphatase cdc25B were synthetically derived from steroids. A preliminary SAR for this new template was elaborated. A series of compounds shows inhibition of cdc25B in the low micromolar range and good selectivity versus other phosphatases. The compounds did not show a significant antiproliferative effect in MaTu or HaCaT cells.
Assuntos
Proteínas de Ciclo Celular/antagonistas & inibidores , Desenho de Fármacos , Inibidores de Proteases/síntese química , Fosfatases cdc25/antagonistas & inibidores , Proteínas de Ciclo Celular/metabolismo , Inibidores de Proteases/metabolismo , Relação Estrutura-Atividade , Fosfatases cdc25/metabolismo
2.